Pediatric Transplantation

Urinary CXCL10/creatinine (uCXCL10/Cr) is an effective biomarker in pediatric kidney transplant recipients for reliably identifying kidney allograft inflammation. This study modelled the clinical implementation of this test and supported a two-test approach to reliably exclude other clinically identifiable sources of inflammation, for kidney biopsy indication to rule-out subclinical rejection.

Kidney Paired Donation provides increased access to high quality living donor organs with possible immunologic, size, age, and logistic advantages for pediatric patients and should be encouraged.

Kidney transplantation before 2 years of age is associated with a survival benefit compared with remaining on the waitlist until older than age 2 years.

This report of the PHTS Registry provides a comprehensive look at over 30 years of data, highlighting both the longevity and unique aspects of the PHTS registry. It specifically delves into the topic of children single ventricle anatomy showing clear improvements in outcomes for children with cardiomyopathy and CHD alike.

Data from children transplanted from 2010 to 2019 were analyzed using machine learning. Single ventricle congenital heart disease contributed most to overall risk in the first year, followed closely by mechanical circulatory support at the time of transplant and a history of cardiac surgery prior to being listed for transplant.