REVIEW ARTICLE
Structure and biomedical applications of bioactive polyphenols from food and fruits
Yuyin Chang,
Fei He,
Tianfu Wang,
Haji Akber Aisa,
Yuyin Chang
China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, PR China
Search for more papers by this authorCorresponding Author
Fei He
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Tianfu Wang
China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, PR China
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Haji Akber Aisa
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorYuyin Chang,
Fei He,
Tianfu Wang,
Haji Akber Aisa,
Yuyin Chang
China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, PR China
Search for more papers by this authorCorresponding Author
Fei He
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Tianfu Wang
China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai, PR China
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Haji Akber Aisa
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, PR China
Correspondence
Tianfu Wang, China-UK Low Carbon College, Shanghai Jiao Tong University, Shanghai 201306, PR China.
Email: [email protected]
Fei He and Haji Akber Aisa, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
Email: [email protected] and [email protected]
Search for more papers by this authorAbstract
Polyphenols, a class of bioactive compounds existing in food and fruit, play an essential role in anti-oxidation, anti-inflammation, anticancer, anti-atherosclerosis, and antiaging by scavenging free radicals, regulating cellular redox potential, signaling pathways, and so on. Due to the low bioavailability/high activity paradox, the functional mechanism of polyphenols in biomedicine has attracted widespread attention. This review summarizes polyphenols (especially quercetin) chemical structure and bioactive mechanism (signaling pathways, enzyme activity, cell redox potential, and gene expression) to show in-depth biomedical functional mechanisms for the control of chronic heath diseases such as oxidation, inflammation, cancer, atherosclerosis, and aging. This study can deepen the understanding of polyphenols' effects on human health.
Novelty impact statement
- Providing another perspective for the comprehensive reuse of polyphenols in food and fruit.
- Summarizing the polyphenols in biomedical research progress of function mechanism.
- Deeping the understanding of the effects of polyphenols on human health.
CONFLICT OF INTEREST
The authors have declared no conflicts of interest for this article.
Open Research
DATA AVAILABILITY STATEMENT
Research data are not shared.
REFERENCES
- Abdal Dayem, A., Choi, H. Y., Yang, G.-M., Kim, K., Saha, S. K., & Cho, S.-G. (2016). The anti-cancer effect of polyphenols against breast cancer and cancer stem cells: Molecular mechanisms. Nutrients, 8(9), 581.
- Abdulkhaleq, L., Assi, M., Abdullah, R., Zamri-Saad, M., Taufiq-Yap, Y., & Hezmee, M. (2018). The crucial roles of inflammatory mediators in inflammation: A review. Veterinary World, 11(5), 627.
- Ahmed, N. A., Radwan, N. M., Ezz, H. S. A., & Salama, N. A. (2017). The antioxidant effect of Green Tea Mega EGCG against electromagnetic radiation-induced oxidative stress in the hippocampus and striatum of rats. Electromagnetic Biology and Medicine, 36(1), 63–73. https://doi.org/10.1080/15368378.2016.1194292
- Alam, J., Wicks, C., Stewart, D., Gong, P. F., Touchard, C., Otterbein, S., Choi, A. M., Burow, M. E., & Tou, J. S. (2000). Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells—Role of p38 kinase and Nrf2 transcription factor. Journal of Biological Chemistry, 275(36), 27694–27702. https://doi.org/10.1074/jbc.M004729200
- Al-Shalmani, S., Suri, S., Hughes, D. A., Kroon, P. A., Needs, P. W., Taylor, M. A., Tribolo, S., & Wilson, V. G. (2011). Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. British Journal of Pharmacology, 162(7), 1485–1497. https://doi.org/10.1111/j.1476-5381.2010.00919.x
- Alvarez, M. C., Maso, V., Torello, C. O., Ferro, K. P., & Saad, S. T. O. (2018). The polyphenol quercetin induces cell death in leukemia by targeting epigenetic regulators of pro-apoptotic genes. Clinical Epigenetics, 10, 11. https://doi.org/10.1186/s13148-018-0563-3
- Ameer, K., Shahbaz, H. M., & Kwon, J. H. (2017). Green extraction methods for polyphenols from plant matrices and their byproducts: A review. Comprehensive Reviews in Food Science and Food Safety, 16(2), 295–315. https://doi.org/10.1111/1541-4337.12253
- Amic, A., Lucic, B., Stepanic, V., Markovic, Z., Markovic, S., Markovic, J. M. D., & Amic, D. (2017). Free radical scavenging potency of quercetin catecholic colonic metabolites: Thermodynamics of 2H(+)/2e(-) processes. Food Chemistry, 218, 144–151. https://doi.org/10.1016/j.foodchem.2016.09.018
- Bandyopadhyay, B., Kostko, O., Fang, Y., & Ahmed, M. (2001). Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro. Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology, 128(2), 153–164.
- Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., & Schilling, B. (2020). A proteomic atlas of senescence-associated secretomes for aging biomarker development. PLoS Biology, 18(1), e3000599.
- Bergamini, C. M., Gambetti, S., Dondi, A., & Cervellati, C. (2004). Oxygen, reactive oxygen species and tissue damage. Current Pharmaceutical Design, 10(14), 1611–1626.
- Bertin, L., Ferri, F., Scoma, A., Marchetti, L., & Fava, F. (2011). Recovery of high added value natural polyphenols from actual olive mill wastewater through solid phase extraction. Chemical Engineering Journal, 171(3), 1287–1293. https://doi.org/10.1016/j.cej.2011.05.056
- Bian, Y., Wei, J., Zhao, C., & Li, G. (2020). Natural polyphenols targeting senescence: A novel prevention and therapy strategy for cancer. International Journal of Molecular Sciences, 21(2), 684. https://doi.org/10.3390/ijms21020684
- Bjornsson, H. T., Sigurdsson, M. I., Fallin, M. D., Irizarry, R. A., Aspelund, T., Cui, H. M., Yu, W., Rongione, M. A., Ekström, T. J., Harris, T. B., Launer, L. J., Eiriksdottir, G., Leppert, M. F., Sapienza, C., Gudnason, V., & Feinberg, A. P. (2008). Intra-individual change over time in DNA methylation with familial clustering. Journal of the American Medical Association, 299(24), 2877–2883. https://doi.org/10.1001/jama.299.24.2877
- Boesch-Saadatmandi, C., Loboda, A., Wagner, A. E., Stachurska, A., Jozkowicz, A., Dulak, J., Döring, F., Wolffram, S., & Rimbach, G. (2011). Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: Role of miR-155. Journal of Nutritional Biochemistry, 22(3), 293–299. https://doi.org/10.1016/j.jnutbio.2010.02.008
- Bors, W., Heller, W., Michel, C., & Saran, M. (1990). Radical chemistry of flavonoid antioxidants. In I. Emerit, L. Packer, & C. Auclair (Eds.), Advances in experimental medicine and biology (Vol. 264, pp. 165–170). Springer. https://doi.org/10.1007/978-1-4684-5730-8_25
- Brown, J. E., Khodr, H., Hider, R. C., & Rice-Evans, C. A. (1998). Structural dependence of flavonoid interactions with Cu2+ ions: Implications for their antioxidant properties. Biochemical Journal, 330(Pt 3), 1173–1178.
- Cai, Y. J., Ma, L. P., Hou, L. F., Zhou, B., Yang, L., & Liu, Z. L. (2002). Antioxidant effects of green tea polyphenols on free radical initiated peroxidation of rat liver microsomes. Chemistry and Physics of Lipids, 120(1-2), 109–117.
- Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011). Cellular senescence: A link between cancer and age-related degenerative disease? Seminars in Cancer Biology, 21(6), 354–359.
- Cantley, L. C. (2002). The phosphoinositide 3-kinase pathway. Science, 296(5573), 1655–1657. https://doi.org/10.1126/science.296.5573.1655
- Cao, H., Chen, X., Jassbi, A. R., & Xiao, J. (2015). Microbial biotransformation of bioactive flavonoids. Biotechnology Advances, 33(1), 214–223. https://doi.org/10.1016/j.biotechadv.2014.10.012
- Cao, W., Ying, D., & Li, A. (2018). Resveratrol boosts cognitive function by targeting SIRT1. Neurochemical Research, 43(9), 1705–1713.
- Carmody, R. J., & Cotter, T. G. (2001). Signalling apoptosis: A radical approach. Redox Report, 6(2), 77–90. https://doi.org/10.1179/135100001101536085
- Cassidy, A., Huang, T., Rice, M. S., Rimm, E. B., & Tworoger, S. S. (2014). Intake of dietary flavonoids and risk of epithelial ovarian cancer. The American Journal of Clinical Nutrition, 100(5), 1344–1351.
- Cerda, B., Espin, J. C., Parra, S., Martinez, P., & Tomas-Barberan, F. A. (2004). The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. European Journal of Nutrition, 43(4), 205–220. https://doi.org/10.1007/s00394-004-0461-7
- Chang, W. S., Lee, Y. J., Lu, F. J., & Chiang, H. C. (1993). Inhibitory effects of flavonoids on xanthine oxidase. Anticancer Research, 13(6A), 2165–2170.
- Chen, J. C., Ho, F. M., Chao, P. D. L., Chen, C. P., Jeng, K. C. G., Hsu, H. B., Lee, S. T., Wu, W. T., & Lin, W. W. (2005). Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of I kappa B kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. European Journal of Pharmacology, 521(1–3), 9–20. https://doi.org/10.1016/j.ejphar.2005.08.005
- Chen, W. C., Lai, Y. A., Lin, Y. C., Ma, J. W., Huang, L. F., Yang, N. S., Ho, C. T., Kuo, S. C., & Way, T. D. (2013). Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells. Journal of Agricultural and Food Chemistry, 61(48), 11817–11824.
- Cho, Y. J., & Kim, S. J. (2013). Effect of quercetin on the production of nitric oxide in murine macrophages stimulated with lipopolysaccharide from Prevotella intermedia. Journal of Periodontal and Implant Science, 43(4), 191–197. https://doi.org/10.5051/jpis.2013.43.4.191
- Choi, E. J., & Kim, G. H. (2013). O-desmethylangolensin inhibits the proliferation of human breast cancer MCF-7 cells by inducing apoptosis and promoting cell cycle arrest. Oncology Letters, 6(6), 1784–1788.
- Chun, J., Ran, J. C., Khan, S., Lee, D. S., Kim, Y. C., Nam, Y. J., Lee, D. U., & Kim, Y. S. (2012). Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. International Immunopharmacology, 14(4), 374–383.
- Ciampa, A. R., de Prati, A. C., Amelio, E., Cavalieri, E., Persichini, T., Colasanti, M., Musci, G., Marlinghaus, E., Suzuki, H., & Mariotto, S. (2005). Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves. FEBS Letters, 579(30), 6839–6845.
- Crawford, D. L., Sinnhuber, R. O., & Aft, H. (1961). The effect of methylation upon the antioxidant and chelation capacity of quercetin and dihydroquercetin in a lard substrate. Journal of Food Science, 26(2), 139–145.
- Cross, T. G., Scheel-Toellner, D., Henriquez, N. V., Deacon, E., Salmon, M., & Lord, J. M. (2000). Serine/threonine protein kinases and apoptosis. Experimental Cell Research, 256(1), 34–41. https://doi.org/10.1006/excr.2000.4836
- Curti, V., Lorenzo, A. D., Dacrema, M., Xiao, J., Nabavi, S. M., & Daglia, M. (2017). In vitro polyphenol effects on apoptosis: An update of literature data. Seminars in Cancer Biology, 46, 119–131. https://doi.org/10.1016/j.semcancer.2017.08.005
- Cutrim, C. S., & Cortez, M. A. S. (2018). A review on polyphenols: Classification, beneficial effects and their application in dairy products. International Journal of Dairy Technology, 71(3), 564–578.
- Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017). Targeting vascular (endothelial) dysfunction. British Journal of Pharmacology, 174(12), 1591–1619.
- Dangles, O. (2012). Antioxidant activity of plant phenols: Chemical mechanisms and biological significance. Current Organic Chemistry, 16(6), 692–714. https://doi.org/10.2174/138527212799957995
- David, A. V. A., Arulmoli, R., & Parasuraman, S. (2016). Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacognosy Reviews, 10(20), 84.
- De Amicis, F., Giordano, F., Vivacqua, A., Pellegrino, M., Panno, M. L., Tramontano, D., Fuqua, S. A., & Andò, S. (2011). Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor alpha gene expression via p38(MAPK)/CK2 signaling in human breast cancer cells. FASEB Journal, 25(10), 3695–3707. https://doi.org/10.1096/fj.10-178871
- Dhaouadi, Z., Nsangou, M., Garrab, N., Anouar, E., Marakchi, K., & Lahmar, S. (2009). DFT study of the reaction of quercetin with· O2-and· OH radicals. Journal of Molecular Structure: THEOCHEM, 904(1-3), 35–42.
- Dilucia, F., Lacivita, V., Conte, A., & Del Nobile, M. A. (2020). Sustainable use of fruit and vegetable by-products to enhance food packaging performance. Foods, 9(7), 857. https://doi.org/10.3390/foods9070857
- Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proceedings of the National Academy of Sciences of the United States of America, 92(20), 9363–9367. https://doi.org/10.1073/pnas.92.20.9363
- Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011). Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nature Reviews Drug Discovery, 10(6), 453–471. https://doi.org/10.1038/nrd3403
- Du, L., Li, J. K., Zhang, X. T., Wang, L. F., Zhang, W. M., Yang, M., & Hou, C. (2019). Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of TLR4/NF-kappa B pathway activation. Food & Nutrition Research, 63, 12. https://doi.org/10.29219/fnr.v63.3392
- Du, L. G., Chen, E. P., Wu, T., Ruan, Y. J., & Wu, S. Z. (2019). Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells. Drug Design, Development and Therapy, 13, 747–755. https://doi.org/10.2147/dddt.S179894
- Duarte, J., Vizcaíno, F. P., Utrilla, P., Jiménez, J., & Zarzuelo, A. (1993). Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. General Pharmacology: The Vascular System, 24(4), 857–862.
- Duenas, M., Gonzalez-Manzano, S., Gonzalez-Paramas, A., & Santos-Buelga, C. (2010). Antioxidant evaluation of O-methylated metabolites of catechin, epicatechin and quercetin. Journal of Pharmaceutical and Biomedical Analysis, 51(2), 443–449. https://doi.org/10.1016/j.jpba.2009.04.007
- Dugas, A. J., Castaneda-Acosta, J., Bonin, G. C., Price, K. L., Fischer, N. H., & Winston, G. W. (2000). Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: Structure-activity relationships. Journal of Natural Products, 63(3), 327–331. https://doi.org/10.1021/np990352n
- Dumont, S., Pennec, S. L., Donnart, A., Teusan, R., Steenman, M., Chevalier, C., Houlgatte, R., & Savagner, F. (2018). Transcriptional orchestration of mitochondrial homeostasis in a cellular model of PGC-1-related coactivator-dependent thyroid tumor. Oncotarget, 9(22), 15883.
- Duranti, G., Ceci, R., Patrizio, F., Sgrò, P., Di Luigi, L., Sabatini, S., Felici, F., & Bazzucchi, I. (2018). Chronic consumption of quercetin reduces erythrocytes oxidative damage: Evaluation at resting and after eccentric exercise in humans. Nutrition Research, 50, 73–81. https://doi.org/10.1016/j.nutres.2017.12.002
- Fadavi, A., Barzegar, M., & Azizi, M. H. (2006). Determination of fatty acids and total lipid content in oilseed of 25 pomegranates varieties grown in Iran. Journal of Food Composition and Analysis, 19(6–7), 676–680.
- Fan, J. B., Cai, X. T., Feng, X. Q., Hou, Y., Xiao-Feng, Y. U., & Jiang, M. (2014). The comparison of five natural phenolic compounds on antioxidant activity in vitro. Food & Fermentation Industries, 40(7), 77–83. https://doi.org/10.13995/j.cnki.11-1802/ts.2014.07.002
- Fang, M. Z., Wang, Y. M., Ai, N., Hou, Z., Sun, Y., Lu, H., Welsh, W., & Yang, C. S. (2003). Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Research, 63(22), 7563–7570.
- Folmer, F., Basavaraju, U., Jaspars, M., Hold, G., El-Omar, E., Dicato, M., & Diederich, M. (2014). Anticancer effects of bioactive berry compounds. Phytochemistry Reviews, 13(1), 295–322.
- Frémont, L., Gozzélino, M. T., Franchi, M. P., & Linard, A. (1998). Dietary flavonoids reduce lipid peroxidation in rats fed polyunsaturated or monounsaturated fat diets. Journal of Nutrition, 128(9), 1495.
- Fuhrman, B., Volkova, N., & Aviram, M. (2005). Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. Journal of Nutritional Biochemistry, 16(9), 570–576. https://doi.org/10.1016/j.jnutbio.2005.02.009
- Galano, A., Munoz-Rugeles, L., Alvarez-Idaboy, J. R., Bao, J. L., & Truhlar, D. G. (2016). Hydrogen abstraction reactions from phenolic compounds by peroxyl radicals: Multireference character and density functional theory rate constants. Journal of Physical Chemistry A, 120(27), 4634–4642. https://doi.org/10.1021/acs.jpca.5b07662
- Galindo, P., Rodriguez-Gómez, I., González-Manzano, S., Dueñas, M., Jiménez, R., Menéndez, C., Vargas, F., Tamargo, J., Santos-Buelga, C., Pérez-Vizcaíno, F., & Duarte, J. (2012). Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One, 7(3), 8. https://doi.org/10.1371/journal.pone.0032673
- Gao, J. J., Filla, M. B., Fultz, M. J., Vogel, S. N., Russell, S. W., & Murphy, W. J. (1998). Autocrine/paracrine IFN-alpha beta mediates the lipopolysaccharide-induced activation of transcription factor Stat1 alpha in mouse macrophages: Pivotal role of Stat1 alpha in induction of the inducible nitric oxide synthase gene. Journal of Immunology, 161(9), 4803–4810.
- Giovannini, C., & Masella, R. (2012). Role of polyphenols in cell death control. Nutritional Neuroscience, 15(3), 134–149. https://doi.org/10.1179/1476830512y.0000000006
- Glasser, G., Graefe, E. U., Struck, F., Veit, M., & Gebhardt, R. (2002). Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites. Phytomedicine, 9(1), 33–40. https://doi.org/10.1078/0944-7113-00080
- González-Sarrías, A., Espín, J. C., Tomás-Barberán, F. A., & García-Conesa, M. T. (2009). Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. Molecular Nutrition & Food Research, 53, 686–698.
- González-Trujano, M. E., Pellicer, F., Mena, P., Moreno, D. A., & García-Viguera, C. (2015). Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins. International Journal of Food Sciences and Nutrition, 66(4), 395–399.
- Gonzalez-Vallinas, M., Gonzalez-Castejon, M., Rodriguez-Casado, A., & Ramirez de Molina, A. (2013). Dietary phytochemicals in cancer prevention and therapy: A complementary approach with promising perspectives. Nutrition Reviews, 71(9), 585–599. https://doi.org/10.1111/nure.12051
- Guilan, L., Yanna, Z., Yuan, Z., Jing, L., Yuming, C., & Wenhua, L. (2013). Estimated daily flavonoid and stilbene intake from fruits, vegetables, and nuts and associations with lipid profiles in Chinese adults. Journal of the Academy of Nutrition and Dietetics, 113(6), 786–794.
- Haddad, E. H., Gaban-Chong, N., Oda, K., & Sabate, J. (2014). Effect of a walnut meal on postprandial oxidative stress and antioxidants in healthy individuals. Nutrition Journal, 13, 4. https://doi.org/10.1186/1475-2891-13-4
- Hamalainen, M., Nieminen, R., Vuorela, P., Heinonen, M., & Moilanen, E. (2007). Anti-inflammatory effects of flavonoids: Genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappa B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappa B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators of Inflammation, 10, 45673. https://doi.org/10.1155/2007/45673
- Harizi, H., & Gualde, N. (2006). Pivotal role of PGE2 and IL-10 in the cross-regulation of dendritic cell-derived inflammatory mediators. Cellular & Molecular Immunology, 3(4), 271–277.
- Harman, D. (2001). Aging: Overview. Annals of the New York Academy of Sciences, 928(1), 1–21.
- Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature, 387(6630), 296–299. https://doi.org/10.1038/387296a0
- Hayashi, T., Sawa, K., Kawasaki, M., Arisawa, M., Shimizu, M., & Morita, N. (1988). Inhibition of cow's milk xanthine oxidase by flavonoids. Journal of Natural Products, 51(2), 345–348. https://doi.org/10.1021/np50056a030
- Hayek, T., Fuhrman, B., Vaya, J., Rosenblat, M., Belinky, P., Coleman, R., Elis, A., & Aviram, M. (1997). Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arteriosclerosis, Thrombosis, and Vascular Biology, 17(11), 2744–2752.
- Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., Georgilis, A., Montoya, A., Wolter, K., Dharmalingam, G., Faull, P., Carroll, T., Martínez-Barbera, J. P., Cutillas, P., Reisinger, F., … Gil, J. (2015). mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype (vol 17, pg 1205, 2015). Nature Cell Biology, 17(10), 1370. https://doi.org/10.1038/ncb3243
- Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1994). Dietary flavonoids and cancer risk in the Zutphen Elderly Study. Nutrition and Cancer, 22(2), 175–184.
- Hess, J., Angel, P., & Schorpp-Kistner, M. (2004). AP-1 subunits: Quarrel and harmony among siblings. Journal of Cell Science, 117(25), 5965–5973. https://doi.org/10.1242/jcs.01589
- Hollman, P. C., & Katan, M. B. (1999). Dietary flavonoids: Intake, health effects and bioavailability. Food and Chemical Toxicology, 37(9-10), 937.
- Horvath, S. (2013). DNA methylation age of human tissues and cell types. Genome Biology, 14(10), 19. https://doi.org/10.1186/gb-2013-14-10-r115
- Hoshino, J., Park, E.-J., Kondratyuk, T. P., Marler, L., Pezzuto, J. M., van Breemen, R. B., Mo, S., Li, Y., & Cushman, M. (2010). Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. Journal of Medicinal Chemistry, 53(13), 5033–5043. https://doi.org/10.1021/jm100274c
- Ireson, C., Orr, S., Jones, D. J. L., Verschoyle, R., Lim, C. K., Luo, J. L., Howells, L., Plummer, S., Jukes, R., Williams, M., Steward, W. P., & Gescher, A. (2001). Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E-2 production. Cancer Research, 61(3), 1058–1064.
- Ishimoto, H., Tai, A., Yoshimura, M., Amakura, Y., & Ito, H. (2012). Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay. Journal of Agricultural Chemical Society of Japan, 76(2), 395–399.
- Jamshidi-Kia, F., Wibowo, J. P., Elachouri, M., Masumi, R., Salehifard-Jouneghani, A., Abolhasanzadeh, Z., & Lorigooini, Z. (2020). Battle between plants as antioxidants with free radicals in human body. Journal of Herbmed Pharmacology, 9(3), 191–199.
- Jones, D. J. (2001). Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Research, 61(3), 1058–1064.
- Joseph, S. V., Edirisinghe, I., & Burton-Freeman, B. M. (2016). Fruit polyphenols: A review of anti-inflammatory effects in humans. Critical Reviews in Food Science and Nutrition, 56(3), 419–444.
- Kageyama, N., Miura, M., Ichinose, M., Tomaki, M., Ishikawa, J., Ohuchi, Y., Endoh, N., & Shirato, K. (1997). Role of endogenous nitric oxide in airway microvascular leakage induced by inflammatory mediators. European Respiratory Journal, 10(1), 13–19.
- Kamijo, R., Harada, H., Matsuyama, T., Bosland, M., Gerecitano, J., Shapiro, D., le, J., Koh, S. I., Kimura, T., & Green, S. J. (1994). Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science (Washington D C), 263(5153), 1612–1615. https://doi.org/10.1126/science.7510419
- Kay, C. D. (2006). Aspects of anthocyanin absorption, metabolism and pharmacokinetics in humans. Nutrition Research Reviews, 19(01), 137–146.
- Kelly, N. P., Kelly, A. L., & O'Mahony, J. A. (2019). Strategies for enrichment and purification of polyphenols from fruit-based materials. Trends in Food Science & Technology, 83, 248–258. https://doi.org/10.1016/j.tifs.2018.11.010
- Khan, H., Reale, M., Ullah, H., Sureda, A., Tejada, S., Wang, Y., Zhang, Z. J., & Xiao, J. (2019). Anti-cancer effects of polyphenols via targeting p53 signaling pathway: Updates and future directions. Biotechnology Advances, 38, 107385.
- Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y., & Kim, H. P. (1999). Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochemical Pharmacology, 58(5), 759.
- Koh, Y.-C., Ho, C.-T., & Pan, M.-H. (2021). Recent advances in health benefits of stilbenoids. Journal of Agricultural and Food Chemistry, 69(35), 10036–10057. https://doi.org/10.1021/acs.jafc.1c03699
- Kumar, G., & Baojun, X. (2017). A critical review on polyphenols and health benefits of black soybeans. Nutrients, 9(5), 455. https://doi.org/10.3390/nu9050455
- Kumar, R., Sharma, A., Kumari, A., Gulati, A., Padwad, Y., & Sharma, R. (2018). Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway. Biogerontology, 20, 1700–1741.
- Lai, C. S., Yang, G., Li, S., Lee, P. S., Wang, B., Chung, M. C., … Ho, C. T. (2017). 3'-Hydroxypterostilbene suppresses colitis-associated tumorigenesis by inhibition of IL-6/ STAT3 signaling in mice. Journal of Agricultural and Food Chemistry, 9655, 9655–9664.
- Lawrence, T., Willoughby, D. A., & Gilroy, D. W. (2002). Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nature Reviews Immunology, 2(10), 787–795.
- Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015). The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature, 524(7565), 309–314.
- Lechtenberg, M., Zumdick, S., Gerhards, C., Schmidt, T. J., & Hensel, A. (2006). Evaluation of analytical markers characterising different drying methods of parsley leaves (Petroselinum crispum L.). Pharmazie, 62(12), 949–954.
- Lee, D. E., Lee, K. W., Jung, S. K., Lee, E. J., Hwang, J. A., Lim, T.-G., Kim, B. Y., Bode, A. M., Lee, H. J., & Dong, Z. (2011). 6,7,4'-Trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. Carcinogenesis, 32(4), 629–635.
- Lee, J., & Mitchell, A. E. (2012). Pharmacokinetics of quercetin absorption from apples and onions in healthy humans. Journal of Agricultural and Food Chemistry, 60(15), 3874–3881. https://doi.org/10.1021/jf3001857
- Lee, S., Bai, S., Lee, K., Namkoong, S., Na, H., Ha, K., Han, J. A., Yim, S. V., Chang, K., Kwon, Y. G., Lee, S. K., & Kim, Y. M. (2003). Anti-inflammatory. Molecules and Cells, 16(1), 97–105.
- Leopoldini, M., Russo, N., & Toscano, M. (2011). The molecular basis of working mechanism of natural polyphenolic antioxidants. Food Chemistry, 125(2), 288–306. https://doi.org/10.1016/j.foodchem.2010.08.012
- Lesjak, M., Beara, I., Simin, N., Pintac, D., Majkic, T., Bekvalac, K., … Mimica-Dukic, N. (2018). Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of Functional Foods, 40, 68–75. https://doi.org/10.1016/j.jff.2017.10.047
- Li, C., Zhang, W. J., Choi, J., & Frei, B. (2016). Quercetin affects glutathione levels and redox ratio in human aortic endothelial cells not through oxidation but formation and cellular export of quercetin-glutathione conjugates and upregulation of glutamate-cysteine ligase. Redox Biology, 9, 220–228. https://doi.org/10.1016/j.redox.2016.08.012
- Li, D., & Mehta, J. L. (2005). Oxidized LDL, a critical factor in atherogenesis. Cardiovascular Research, 68, 353–354.
- Li, F., Li, S., Li, H.-B., Deng, G.-F., Ling, W.-H., & Xu, X.-R. (2013). Antiproliferative activities of tea and herbal infusions. Food & Function, 4(4), 530–538. https://doi.org/10.1039/c2fo30252g
- Li, S., Cao, H., Shen, D., Jia, Q., Chen, C., & Xing, S. L. (2018). Quercetin protects against ox-LDL-induced injury via regulation of ABCAl, LXR-α and PCSK9 in RAW264. 7 macrophages. Molecular Medicine Reports, 18(1), 799–806.
- Libby, P., Aikawa, M., & Jain, M. (2006). Vascular endothelium and atherosclerosis. The Vascular Endothelium, II, 285–306.
10.1007/3-540-36028-X_9 Google Scholar
- Liu, S. F., & Malik, A. B. (2006). NF-kappa B activation as a pathological mechanism of septic shock and inflammation. American Journal of Physiology—Lung Cellular and Molecular Physiology, 290(4), L622–L645. https://doi.org/10.1152/ajplung.00477.2005
- Liu, Z., Xie, Z., Jones, W., Pavlovicz, R. E., Liu, S., Yu, J., Li, P. K., Lin, J., Fuchs, J. R., Marcucci, G., Li, C., & Chan, K. K. (2009). Curcumin is a potent DNA hypomethylation agent. Bioorganic & Medicinal Chemistry Letters, 19(3), 706–709.
- Lodi, F., Jimenez, R., Moreno, L., Kroon, P. A., Needs, P. W., Hughes, D. A., Santos-Buelga, C., Gonzalez-Paramas, A., Cogolludo, A., Lopez-Sepulveda, R., Duarte, J., & Perez-Vizcaino, F. (2009). Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis, 204(1), 34–39.
- Luca, S. V., Macovei, I., Bujor, A., Miron, A., Skalicka-Wozniak, K., Aprotosoaie, A. C., & Trifan, A. (2020). Bioactivity of dietary polyphenols: The role of metabolites. Critical Reviews in Food Science and Nutrition, 60(4), 626–659. https://doi.org/10.1080/10408398.2018.1546669
- Ludwig, S., Hoffmeyer, A., Goebeler, M., Kilian, K., Häfner, H., Neufeld, B., Han, J., & Rapp, U. R. (1998). The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6 p38-dependent pathway. Journal of Biological Chemistry, 273(4), 1917–1922. https://doi.org/10.1074/jbc.273.4.1917
- Luo, Q., Zhang, J. R., Li, H. B., Wu, D. T., Geng, F., Corke, H., Wei, X. L., & Gan, R. Y. (2020). Green extraction of antioxidant polyphenols from green tea (Camellia sinensis). Antioxidants (Basel), 9(9), 785. https://doi.org/10.3390/antiox9090785
- Luo, W., Xiao, G., Tian, F., Richardson, J. J., Wang, Y., Zhou, J., … Shi, B. (2019). Engineering robust metal-phenolic network membranes for uranium extraction from seawater. Energy & Environmental Science, 12(2), 607–614. https://doi.org/10.1039/c8ee01438h
- Lutz, M., Martínez, A., & Martínez, E. A. (2013). Daidzein and genistein contents in seeds of quinoa (Chenopodium quinoa Willd.) from local ecotypes grown in arid Chile. Industrial Crops and Products, 49, 117–121.
- Lv, K., Zhang, L., Zhao, H., Ho, C. T., & Li, S. (2021). Recent study on the anticancer activity of nobiletin and its metabolites. Journal of Food Bioactives, 14. https://doi.org/10.31665/JFB.2021.14267
10.31665/JFB.2021.14267 Google Scholar
- Mao, X., Gu, C., Chen, D., Yu, B., & He, J. (2017). Oxidative stress-induced diseases and tea polyphenols. Oncotarget, 8(46), 5374–5378.
10.18632/oncotarget.20887 Google Scholar
- Mária, J., & Ingrid, I. (2017). Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro. Food & Function, 8(7), 2394–2418. https://doi.org/10.1039/c7fo00161d
- Marino, G., Pietrocola, F., Madeo, F., & Kroemer, G. (2014). Caloric restriction mimetics: Natural/physiological pharmacological autophagy inducers. Autophagy, 10(11), 1879–1882. https://doi.org/10.4161/auto.36413
- Marković, Z. S., Dimitrić Marković, J. M., & Doličanin, Ć. B. (2010). Mechanistic pathways for the reaction of quercetin with hydroperoxy radical. Theoretical Chemistry Accounts, 127(1), 69–80.
- Medina-Franco, J. L., López-Vallejo, F., Kuck, D., & Lyko, F. (2011). Natural products as DNA methyltransferase inhibitors: A computer-aided discovery approach. Molecular Diversity, 15(2), 293–304.
- Meyer, M., Rastogi, P., Beckett, C., & McHowat, J. (2005). Phospholipase A2 inhibitors as potential anti-inflammatory agents. Current Pharmaceutical Design, 11(10), 1301–1312.
- Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000). The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 52(4), 673–751.
- Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999). The p66(shc) adaptor protein controls oxidative stress response and life span in mammals. Nature, 402(6759), 309–313. https://doi.org/10.1038/46311
- Mitani, K., Narimatsu, S., & Kataoka, H. (2003). Determination of daidzein and genistein in soybean foods by automated on-line in-tube solid-phase microextraction coupled to high-performance liquid chromatography. Journal of Chromatography A, 986(2), 169–177.
- Mitchell, J. A., Ali, F., Bailey, L., Moreno, L., & Harrington, L. S. (2008). Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium. Experimental Physiology, 93(1), 141–147. https://doi.org/10.1113/expphysiol.2007.038588
- Miyata, Y., Shida, Y., Hakariya, T., & Sakai, H. (2019). Anti-cancer effects of green tea polyphenols against prostate cancer. Molecules, 24(1), 193.
- Moncada, S., & Higgs, E. A. (2006). Nitric oxide and the vascular endothelium. In S. Moncada & A. Higgs (Eds.), Vascular endothelium I (Vol. 176, pp. 213–254). Springer.
10.1007/3-540-32967-6_7 Google Scholar
- Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013). Macrophages in atherosclerosis: A dynamic balance. Nature Reviews Immunology, 13(10), 709–721. https://doi.org/10.1038/nri3520
- Moore, L. D., Le, T., & Fan, G. P. (2013). DNA Methylation and Its Basic Function. Neuropsychopharmacology, 38(1), 23–38. https://doi.org/10.1038/npp.2012.112
- Morales, N. P., Sirijaroonwong, S., Yamanont, P., & Phisalaphong, C. (2015). Electron paramagnetic resonance study of the free radical scavenging capacity of curcumin and its demethoxy and hydrogenated derivatives. Biological & Pharmaceutical Bulletin, 38(10), 1478–1483. https://doi.org/10.1248/bpb.b15-00209
- Morse, D., Pischke, S. E., Zhou, Z. H., Davis, R. J., Flavell, R. A., Loop, T., Otterbein, S. L., Otterbein, L. E., & Choi, A. M. K. (2003). Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. Journal of Biological Chemistry, 278(39), 36993–36998. https://doi.org/10.1074/jbc.M302942200
- Mu, M. M., Chakravortty, D., Sugiyama, T., Koide, N., Takahashi, K., Mori, I., Yoshida, T., & Yokochi, T. (2001). The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells. Journal of Endotoxin Research, 7(6), 431–438. https://doi.org/10.1179/096805101101533034
- Murphy, K. J., Walker, K. M., Dyer, K. A., & Bryan, J. (2019). Estimation of daily intake of flavonoids and major food sources in middle-aged Australian men and women. Nutrition Research, 61, 64–81. https://doi.org/10.1016/j.nutres.2018.10.006
- Nakagawa, T., & Yokozawa, T. (2002). Direct scavenging of nitric oxide and superoxide by green tea. Food and Chemical Toxicology, 40(12), 1745–1750.
- Nathiya, S., Durga, M., & Thiyagarajan, D. (2014). Quercetin, encapsulated quercetin and its application-a review. International Journal of Pharmacy and Pharmaceutical Sciences, 6, 20–26.
- Nie, G., Cao, Y., & Zhao, B. (2002). Protective effects of green tea polyphenols and their major component, (–)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells. Redox Report Communications in Free Radical Research, 7(3), 171–177.
- Nieman, D. C., Williams, A. S., Shanely, R. A., Jin, F., McAnulty, S. R., Triplett, N. T., Austin, M. D., & Henson, D. A. (2010). Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Medicine and Science in Sports and Exercise, 42(2), 338–345. https://doi.org/10.1249/MSS.0b013e3181b18fa3
- Ohanna, M., Giuliano, S., Bonet, C., Imbert, V., Hofman, V., Zangari, J., Bille, K., Robert, C., Bressac-de Paillerets, B., Hofman, P., Rocchi, S., Peyron, J.-F., Lacour, J.-P., Ballotti, R., & Bertolotto, C. (2011). Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS). Genes & Development, 25, 1245–1261.
- Okoko, T., & Oruambo, I. F. (2009). Inhibitory activity of quercetin and its metabolite on lipopolysaccharide-induced activation of macrophage U937 cells. Food and Chemical Toxicology, 47(4), 809–812. https://doi.org/10.1016/j.fct.2009.01.013
- Oliviero, F., Scanu, A., Zamudio-Cuevas, Y., Punzi, L., & Spinella, P. (2018). Anti-inflammatory effects of polyphenols in arthritis. Journal of the Science of Food and Agriculture, 98(5), 1653–1659.
- Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000). Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature Medicine, 6(4), 422–428.
- Pagano, I., Campone, L., Celano, R., Piccinelli, A. L., & Rastrelli, L. (2021). Green non-conventional techniques for the extraction of polyphenols from agricultural food by-products: A review. Journal of Chromatography A, 1651, 462295. https://doi.org/10.1016/j.chroma.2021.462295
- Pan, P., Huang, Y. W., Oshima, K., Yearsley, M., Zhang, J., Yu, J., Arnold, M., & Wang, L. S. (2018). An immunological perspective for preventing cancer with berries. Journal of Berry Research, 8(3), 163–175.
- Patel, K. R., Andreadi, C., Britton, R. G., Hornerglister, E., Karmokar, A., Sale, S., Brown, V. A., Brenner, D. E., Singh, R., Steward, W. P., Gescher, A. J., & Brown, K. (2014). Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Autophagy, 5(3), ra133-525.
- Pérezvizcaíno, F., Ibarra, M., Cogolludo, A. L., Duarte, J., Zaragozáarnáez, F., Moreno, L., … Tamargo, J. (2002). Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries. Journal of Pharmacology and Experimental Therapeutics, 302(1), 66–72.
- Pietta, P. G. (2000). Flavonoids as antioxidants. Journal of Natural Products, 63(7), 1035–1042. https://doi.org/10.1021/np9904509
- Pollard, S. E., Kuhnle, G. G. C., Vauzour, D., Vafeiadou, K., Tzounis, X., Whiteman, M., Rice-Evans, C., & Spencer, J. P. E. (2006). The reaction of flavonoid metabolites with peroxynitrite. Biochemical and Biophysical Research Communications, 350(4), 960–968. https://doi.org/10.1016/j.bbrc.2006.09.131
- Pollock, J. S., Forstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H., Nakane, M., & Murad, F. (1991). Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proceedings of the National Academy of Sciences of the United States of America, 88(23), 10480–10484. https://doi.org/10.1073/pnas.88.23.10480
- Prakash, M. D., Stojanovska, L., Feehan, J., Nurgali, K., Donald, E. L., Plebanski, M., Flavel, M., Kitchen, B., & Apostolopoulos, V. (2021). Anti-cancer effects of polyphenol-rich sugarcane extract. PLoS One, 16(3), e0247492.
- Pu, D., Duan, W., Huang, Y., Zhang, L., Zhang, Y., Sun, B., Ren, F., Zhang, H., & Tang, Y. (2021). Characterization of the dynamic texture perception and the impact factors on the bolus texture changes during oral processing. Food Chemistry, 339, 128078. https://doi.org/10.1016/j.foodchem.2020.128078
- Rady, H. M., Hemmaid, K. Z., Esmaeil, N. N., Eid, M. M., & Elshat, A. A. (2018). Sidr Kashmiry honey and its fractions induced apoptosis in hepatocellular carcinoma in vitro. Mediterranean Journal of Nutrition and Metabolism, 11(3), 343–351.
- Rafi, M. M., Vastano, B. C., Zhu, N., Ho, C. T., Ghai, G., Rosen, R. T., Gallo, M. A., & DiPaola, R. (2002). Novel polyphenol molecule isolated from licorice root (Glycrrhiza glabra) induces apoptosis, G2/M cell cycle arrest, and Bcl-2 phosphorylation in tumor cell lines. Journal of Agricultural and Food Chemistry, 50(4), 677–684.
- Raso, G. M., Meli, R., Di Carlo, G., Pacilio, M., & Di Carlo, R. (2001). Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sciences, 68(8), 921–931. https://doi.org/10.1016/s0024-3205(00)00999-1
- Rasouli, H., Farzaei, M. H., & Khodarahmi, R. (2017). Polyphenols and their benefits: A review. International Journal of Food Properties, 20, 1700–1741. https://doi.org/10.1080/10942912.2017.1354017
- Renouard, S., Hano, C., Corbin, C., Fliniaux, O., Lopez, T., Montguillon, J., … Lainé, E. (2010). Cellulase-assisted release of secoisolariciresinol from extracts of flax (Linum usitatissimum) hulls and whole seeds. Food Chemistry, 122(3), 679–687. https://doi.org/10.1016/j.foodchem.2010.03.036
- Romero, M., Jiménez, R., Sánchez, M., López-Sepúlveda, R., Zarzuelo, M. J., O'Valle, F., Zarzuelo, A., Pérez-Vizcaíno, F., & Duarte, J. (2009). Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC. Atherosclerosis, 202(1), 58–67.
- Safdar, M. N., Kausar, T., & Nadeem, M. (2017). Comparison of ultrasound and maceration techniques for the extraction of polyphenols from the mango peel. Journal of Food Processing and Preservation, 41(4), e13028. https://doi.org/10.1111/jfpp.13028
- Saien, J., & Daneshamoz, S. (2018). Experimental studies on the effect of ultrasonic waves on single drop liquid–liquid extraction. Ultrasonics Sonochemistry, 40, 11–16. https://doi.org/10.1016/j.ultsonch.2017.06.020
- Sajadimajd, S., Bahramsoltani, R., Iranpanah, A., Kumar Patra, J., Das, G., Gouda, S., Rahimi, R., Rezaeiamiri, E., Cao, H., Giampieri, F., Battino, M., Tundis, R., Campos, M. G., Farzaei, M. H., & Xiao, J. B. (2020). Advances on natural polyphenols as anticancer agents for skin cancer. Pharmacological Research, 151, 14. https://doi.org/10.1016/j.phrs.2019.104584
- Sarady-Andrews, J. K., Liu, F., Gallo, D., Nakao, A., Overhaus, M., Ollinger, R., Choi, A. M., & Otterbein, L. E. (2005). Biliverdin administration protects against endotoxin-induced acute lung injury in rats. American Journal of Physiology—Lung Cellular and Molecular Physiology, 289(6), L1131–L1137. https://doi.org/10.1152/ajplung.00458.2004
- Scher, J. U., & Pillinger, M. H. (2009). The anti-inflammatory effects of prostaglandins. Journal of Investigative Medicine, 57(6), 703–708.
- Schmitz, G., & Grandl, M. (2007). Role of redox regulation and lipid rafts in macrophages during Ox-LDL–mediated foam cell formation. Antioxidants & Redox Signaling, 9(9), 1499–1518.
- Schroeter, A., Groh, I. A. M., Del Favero, G., Pignitter, M., Schueller, K., Somoza, V., & Marko, D. (2016). Inhibition of topoisomerase II by phase II metabolites of resveratrol in human colon cancer cells. Molecular Nutrition & Food Research, 59(12), 2448–2459.
- Selma, M. V., Espin, J. C., & Tomas-Barberan, F. A. (2009). Interaction between phenolics and gut microbiota: Role in human health. Journal of Agricultural and Food Chemistry, 57(15), 6485–6501.
- Sen, S., Chakraborty, R., Sridhar, C., Reddy, Y., & De, B. (2010). Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. International journal of pharmaceutical sciences review and research, 3(1), 91–100.
- Sethi, G., & Tergaonkar, V. (2009). Potential pharmacological control of the NF-kappa B pathway. Trends in Pharmacological Sciences, 30(6), 313–321. https://doi.org/10.1016/j.tips.2009.03.004
- Shan, Z., Liu, Q., Li, Y., Wu, J., Sun, D., & Gao, Z. (2017). PUMA decreases the growth of prostate cancer PC-3 cells independent of p53. Oncology Letters, 13(3), 1885–1890. https://doi.org/10.3892/ol.2017.5657
- Sharma, D. R., Sunkaria, A., Wani, W. Y., Sharma, R. K., Verma, D., Priyanka, K., Bal, A., & Gill, K. D. (2015). Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1 alpha signaling pathway. Neurotoxicology, 51, 116–137. https://doi.org/10.1016/j.neuro.2015.10.002
- Sharma, V., Kumar, L., Mohanty, S. K., Maikhuri, J. P., Rajender, S., & Gupta, G. (2016). Sensitization of androgen refractory prostate cancer cells to anti androgens through re-expression of epigenetically repressed androgen receptor—Synergistic action of quercetin and curcumin. Molecular and Cellular Endocrinology, 431, 12–23. https://doi.org/10.1016/j.mce.2016.04.024
- Shen, X., Lu, R., & Wu, M. (1998). Effects of tea polyphenol on blood lipid and antioxidation in vivo in aged rats. Chinese Journal of Preventive Medicine, 32(1), 34.
- Shi, J., Liu, F., Zhang, W., Liu, X., Lin, B., & Tang, X. (2015). Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells. Oncology Reports, 33(6), 2972.
- Shinde, A., Ganu, J., & Naik, P. (2012). Effect of free radicals & antioxidants on oxidative stress: A review. Journal of Dental and Allied Sciences, 1(2), 63.
10.4103/2277-4696.159144 Google Scholar
- Silva, E., Cajueiro, J., Silva, S., Soares, P., & Guerra, M. (2012). Effect of antioxidants resveratrol and quercetin on in vitro evaluation of frozen ram sperm. Theriogenology, 77(8), 1722–1726.
- Steptoe, A., Hamer, M., & Chida, Y. (2007). The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain, Behavior, and Immunity, 21(7), 901–912.
- Storniolo, C. E., & Moreno, J. J. (2012). Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells. Food Chemistry, 134(3), 1385–1391.
- Sun, C., Wang, H., Wang, D., Chen, Y., Zhao, Y., & Xia, W. (2015). Using an FFQ to assess intakes of dietary flavonols and flavones among female adolescents in the Suihua area of northern China. Public Health Nutrition Cab International, 18(4), 632–639.
- Sundaram, M. K., Hussain, A., Haque, S., Raina, R., & Afroze, N. (2019). Quercetin modifies 5' CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells. Journal of Cellular Biochemistry, 120(10), 18357–18369. https://doi.org/10.1002/jcb.29147
- Szwajgier, D., Paduch, R., Kukula-Koch, W., Polak-Berecka, M., & Wasko, A. (2020). Study on biological activity of bread enriched with natural polyphenols in terms of growth inhibition of tumor intestine cells. Journal of Medicinal Food, 23(2), 181–190. https://doi.org/10.1089/jmf.2019.0082
- Tan, S., Yu, C. Y., Sim, Z. W., Low, Z. S., Lee, B., See, F., Min, N., Gautam, A., Chu, J. J. H., Ng, K. W., & Wong, E. (2019). Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy. Scientific Reports, 9, 18. https://doi.org/10.1038/s41598-018-37400-1
- Tanaka, K.-I., Suemasu, S., Ishihara, T., Tasaka, Y., Arai, Y., & Mizushima, T. (2009). Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)-dependent exacerbation of colitis. European Journal of Pharmacology, 603(1–3), 120–132.
- Tang, Y., Nakashima, S., Saiki, S., Myoi, Y., Abe, N., Kuwazuru, S., Zhu, B., Ashida, H., Murata, Y., & Nakamura, Y. (2016). 3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides. Food Research International, 89, 716–723. https://doi.org/10.1016/j.foodres.2016.09.034
- Tauber, A. I. (1984). Flavonoid inhibition of the human neutrophil NADPH-oxidase. Biochemical Pharmacology, 33(8), 1367–1369.
- Tomás-Barberán, F. A., & Clifford, M. N. (2000). Flavanones, chalcones and dihydrochalcones—Nature, occurrence and dietary burden. Journal of the Science of Food and Agriculture, 80(7), 1073–1080.
10.1002/(SICI)1097-0010(20000515)80:7<1073::AID-JSFA568>3.0.CO;2-B CAS Web of Science® Google Scholar
- Tsai, H. Y., Ho, C. T., & Chen, Y. K. (2017). Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene. Journal of Food and Drug Analysis, 25(1), 134–147.
- Tugba, O., Sela, D. A., Xiao, J., Dilek, B., Fang, C., & Esra, C. (2016). The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients, 8(2), 78.
- Vachier, I., Chanez, P., Bonnans, C., Godard, P., Bousquet, J., & Chavis, C. (2002). Endogenous anti-inflammatory mediators from arachidonate in human neutrophils. Biochemical and Biophysical Research Communications, 290(1), 219–224.
- Vaganek, A., Rimarcik, J., Dropkova, K., Lengyel, J., & Klein, E. (2014). Reaction enthalpies of O-H bonds splitting-off in flavonoids: The role of non-polar and polar solvent. Computational and Theoretical Chemistry, 1050, 31–38. https://doi.org/10.1016/j.comptc.2014.10.020
- Valenti, D., de Rasmo, D., Signorile, A., Rossi, L., de Bari, L., Scala, I., Granese, B., Papa, S., & Vacca, R. A. (2013). Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1832(4), 542–552. https://doi.org/10.1016/j.bbadis.2012.12.011
- Vanessa, P., Alessandra, M., Anna, L., Elisa, G., Ingrid, C., Cristina, B., … Lisa, G. (2012). Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 68(4), 371–381.
- Varmus, H. (2006). The new era in cancer research. Science, 312(5777), 1162–1165.
- Vicinanza, R., Zhang, Y., Henning, S. M., & Heber, D. (2013). Pomegranate juice metabolites, ellagic acid and urolithin a, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle control and apoptosis. Evidence-based Complementary and Alternative Medicine, 2013, 1–12.
- Walker, J., Schueller, K., Schaefer, L.-M., Pignitter, M., Esefelder, L., & Somoza, V. (2014). Resveratrol and its metabolites inhibit pro-inflammatory effects of lipopolysaccharides in U-937 macrophages in plasma-representative concentrations. Food & Function, 5(1), 74–84. https://doi.org/10.1039/c3fo60236b
- Wang, T., Zhao, Q., Li, C., He, F., Jiang, L., & Aisa, H. A. (2021). Integrating chemical and biological catalysis for simultaneous production of polyphenolics and butyric acid from waste pomegranate peels. Science of the Total Environment, 778, 146095. https://doi.org/10.1016/j.scitotenv.2021.146095
- Wang, X., Yan, J., Wang, Y. W., Huang, M. T., Ho, C. T., & Huang, Q. (2008). Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chemistry, 108(2), 419–424.
- Wang, Z., Guo, X., Zhang, Q., Du, G., Zeng, Z., Zheng, C., & Wei, Y. (2021). Elimination of Ox-LDL through the liver inhibits advanced atherosclerotic plaque progression. International Journal of Medical Sciences, 18(16), 3652.
- Wang, A. S., & Dreesen, O. (2018). Biomarkers of cellular senescence and skin aging. Frontiers in Genetics, 9, 247.
- Watanabe, S., Kawamoto, S., Ohtani, N., & Hara, E. (2017). The impact of SASP and its potential as a therapeutic target for senescence-associated diseases. Cancer Science, 108(4), 563–569.
- Wataru, K., Hisashi, K., Kazumi, Y., & Shuji, O. (2018). Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species. European Journal of Pharmacology, 833, 411–424. https://doi.org/10.1016/j.ejphar.2018.06.023
- Weinberg, R. A. (1996). How cancer arises. Scientific American, 275(3), 62–70.
- Xie, L., & Boiling, B. W. (2014). Characterisation of stilbenes in California almonds (Prunus dulcis) by UHPLC-MS. Food Chemistry, 148(apr.1), 300–306.
- Xu, D., Liang, H., Zhu, X., Yang, L., Luo, X., Guo, Y., … Tang, X. (2020). Metal-polyphenol dual crosslinked graphene oxide membrane for desalination of textile wastewater. Desalination, 487, 114503. https://doi.org/10.1016/j.desal.2020.114503
- Yahfoufi, N., Alsadi, N., Jambi, M., & Matar, C. (2018). The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients, 10(11), 1618.
- Yang, Y., Zheng, R., Zhang, P., Wen, J., Luo, Y., Zhao, Z., You, L., & Ho, C.-T. (2022). Combination effects of polyphenols present in sugarcane on proliferation in MCF-7 human breast cancer cells. Sugar Tech, 24(3), 832–840. https://doi.org/10.1007/s12355-021-01039-6
- Yao, D., Tang, C., Li, L., Xia, B., Vasileff, A., Jin, H., … Qiao, S.-Z. (2020). In situ fragmented bismuth nanoparticles for electrocatalytic nitrogen reduction. Advanced Energy Materials, 10(33), 2001289. https://doi.org/10.1002/aenm.202001289
- Yessenkyzy, A., Saliev, T., Zhanaliyeva, M., Masoud, A.-R., Umbayev, B., Sergazy, S., Krivykh, E., Gulyayev, A., & Nurgozhin, T. (2020). Polyphenols as caloric-restriction mimetics and autophagy inducers in aging research. Nutrients, 12(5), 1344. https://doi.org/10.3390/nu12051344
- Yiannakopoulou, C. E. (2013). Targeting oxidative stress response by green tea polyphenols: Clinical implications. Free Radical Research, 47(9), 667–671.
- Yousefian, M., Shakour, N., Hosseinzadeh, H., Hayes, A. W., Hadizadeh, F., & Karimi, G. (2019). The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine, 55, 200–213.
- Yoysungnoen, P., Wirachwong, P., Changtam, C., Suksamrarn, A., & Patumraj, S. (2008). Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World Journal of Gastroenterology, 014(013), 2003–2009.
- Zderic, A., & Zondervan, E. (2017). Product-driven process synthesis: Extraction of polyphenols from tea. Journal of Food Engineering, 196, 113–122. https://doi.org/10.1016/j.jfoodeng.2016.10.019
- Zhang, H., & Tsao, R. (2016). Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current Opinion in Food Science, 8, 33–42.
- Zhang, L., Han, Z., & Granato, D. (2021). Polyphenols in foods: Classification, methods of identification, and nutritional aspects in human health. In Advances in food and nutrition research (Vol. 98, pp. 1–33). Elsevier.
- Zhang, M., Zhang, X., Ho, C. T., & Huang, Q. (2018). Chemistry and health effect of tea polyphenol (-)-epigallocatechin 3-O-(3- O-methyl)gallate. Journal of Agricultural and Food Chemistry, 67(19), 5374–5378.
- Zhang, X., & Zhao, X. H. (2008). Antioxidant activities of some polyphenols evaluated by different chemical methods and correlation analysis. Food Ence, 29(10), 85–89.
- Zhang, X. C., Bedard, E. L., Potter, R., Zhong, R., Alam, J., Choi, A. M. K., & Lee, P. J. (2002). Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. American Journal of Physiology—Lung Cellular and Molecular Physiology, 283(4), L815–L829. https://doi.org/10.1152/ajplung.00485.2001
- Zheng, Y.-Z., Deng, G., Liang, Q., Chen, D.-F., Guo, R., & Lai, R.-C. (2017). Antioxidant activity of quercetin and its glucosides from propolis: A theoretical study. Scientific Reports, 7(1), 1–11.
- Zulaikhah, S. T. (2017). The role of antioxidant to prevent free radicals in the body. Sains Medika, 8(1), 39–45.
10.26532/sainsmed.v8i1.1012 Google Scholar
