We performed proteomic analysis by mass spectroscopy to identify novel citrullinated antigens and autoantibodies in RA patients. Graphical Abstract image see the attachment.

Supported by a research grant from the Department of Science and Technology Philippine Council for Health Research and Development

HLA-B and HLA-DRB1 alleles are not merely susceptibility or protective genes, but also are associated with disease activity, specific system involvement, inflammation and auto-antibodies production.

We report a case of a 43-year-old woman who initially presented with peptic ulcers, recurrent oral ulcers, and suspicious genital ulcers resembling Behcet's syndrome. Her symptoms were not relieved by systemic steroids and gradually presented multiple system damage involving kidney, heart, lung, skin, and mucous membranes. She was diagnosed with systemic immunoglobulin light chain (AL)  amyloidosis after three biopsies.

(A) An invasive ulcer presented in nasal limbus with perforation and iris prolapse at 9 o'clock in the right eye of a 64-year-old female with rheumatoid arthritis. (B) Seven months after the treatment with tocilizumab. Corneal pannus completely covers the ulcer surface. The central depth of the anterior chamber was 4ct, anterior synechia, normal fundus.