The lncRNAs acting as ceRNAs may serve as a biomarker for the diagnosis, prognosis, and prediction of therapeutic responses in colorectal cancer.

Patients with limited-stage BL had a significantly better 5-year overall survival (OS) in the 2002-2014 era in both univariate analysis and multivariate analysis, compared with those in the 1983-2001 era (64.1% vs 57.4%). However, clinical outcomes of elderly patients (≥60 years) and children patients (0-19 years) did not significantly improve.

Real-world data on treatment with FOLFIRI/aflibercept. Safety, efficacy, and subgroup analyses. Importance of HTA development.

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Our study is the first to directly compare not only clinical survival outcomes, but also late toxicities of postoperative intensity-modulated radiation therapy (IMRT) and two-dimensional radiotherapy (2D-RT) for patients with STS of extremities and trunk, and our results demonstrated that IMRT provided better local control (5 year 91.1% vs. 80.8%) and OS (5 year 90.2% vs. 81.0%) and less severe late toxicities compared with 2D-RT.

This prospective research is the first one to conduct an integrated liquid biopsy based on three types of liquid samples including plasma, sputum, and urine compared with matched tumor tissue under the same NGS platform in advanced NSCLC. It was demonstrated for the first time that sputum cfDNA can be considered as an alternative medium to liquid biopsy. And the complementarity in genomic profiles of cfDNA among various bio-samples enables the combination of plasma, sputum, and urine to detect more diver genes alterations and improve the utility of liquid biopsy in clinical practice of advanced NSCLC.

Collectively, our data demonstrate that sFR could improve diagnostic accuracy. Additionally, the monitoring of sFR and CA125 (and potentially other markers) could conceivably improve cancer surveillance, affecting prognosis. We have initiated a prospective clinical trial studying sFR induction in the initial diagnosis and surveillance of OVCA as a means to abrogate potential limitations of this biomarker.

Stereotactic body radiation therapy is growing in use and acceptance for treating unresectable hepatocellular carcinoma. There is a wide variety of dose schemas used in clinical practice. Multiple factors are associated with dose selection and fractionation, with more favorable patients receiving higher doses and having better outcomes.

Prior NCDB studies have demonstrated an overall survival benefit for adjuvant concurrent chemoradiation compared to chemotherapy alone for resectable pancreatic cancer. In this retrospective propensity-matched study of the NCDB including 5667 patients, postoperative chemotherapy followed by adjuvant chemoradiation showed improved survival for resected stage I-II pancreatic cancer compared to adjuvant chemoradiation or chemotherapy alone.

In DLBCL patients, high total metabolic tumor burden calculated using 18F-FDG PET/CT images at diagnosis predicts poor prognosis. We found serum level of sIL-2R represents a convenient surrogate marker to estimate metabolic tumor burden measured by 18F-FDG PET/CT that can predict treatment outcomes of patients with DLBCL.

This is a rare study to investigate the relationship among daily activity, mood, and quality of life (QoL) in colorectal cancer patients with chemotherapy-induced peripheral neuropathy (CIPN), by using the mediation effect analysis. According to the results, the mediation effect of mood between daily activities and QoL should be further emphasized for colorectal cancer patients with CIPN.

This study aimed to investigate the prognostic significance of mast cells and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1. Our results revelead an important novel finding by confirming the association of microvascular density in the tumor periphery (higher tercile, p = 0.019) with a decreased overall survival. Diverse mast cells and microvascular distributions suggest that angiogenesis occurs independently.

Among patients with diffuse large B-cell lymphoma with gastric lesions (DLBCL-GL) treated with R-CHOP, patients with gastric complications had a lower R-CHOP completion rate and a lower complete remission rate than those without complications. The importance of this study is to provide important information about management of DLBCL-GL to prevent gastric complications, which may result in better survival.

This study demonstrated that TET1 expression reverses gemcitabine resistance in CCA accompanied by a reduction in P-gp expression. Thus, TET1 may be a promising target to overcome the chemoresistance in CCA.

Previous studies reported the association between NLR and pathological characteristics of prostate cancer, and patients with preoperative high-NLR had significantly poorer BCR-free survival. This study contradicts these reports, and reports that there is no association between preoperative NLR and pathological features and representative molecules of biological function (eg. AR, ERG, PTEN, p-AKT, Bcl-2, Beclin-1, Ki-67) and the local microenvironment (eg. infiltrating CD3⁺ cells, the CD4/CD8 ratio,IFN-γ and TNF-α) of localized prostate cancer. Furthermore, it also reveals that a high NLR can serve as an independent predictor of better BCR. Additionally, univariate analysis indicated that a high NLR was associated with poor overall survival, but this correlation was not verified in the multivariate analysis. NLR, as a reliable, easily accessible and inexpensive biomarker, might benefit individual risk assessment and patient stratification.

We sequenced viral DNA from paraffin-embedded tissues of PTLD and associated to clinical severity and outcomes. Certain EBV genes had higher proportions of nonsynonymous variants. Anellovirus tissue positivity associated with earlier patient death.

We define the risk factors for the cancer-specific survival (CSS) of patients with pT3N0 rectal cancer and develop a risk-stratification model that would be able to identify which of these patients might benefit from adjuvant radiotherapy.

The current data showed better survival in patients with metastatic or recurrent gastrointestinal stromal tumors (GISTs) who were initiated on 400 mg/d imatinib at a single institution, with an experienced GIST team. Along with appropriate patient management of maintaining imatinib treatment without unnecessary interruption, more commonly used subsequent tyrosine kinase inhibitors and active surgical intervention may also be responsible for improved survival rates.

This nationwide cohort study of 476 patients with cancer-associated VTE initiating rivaroxaban showed a 6 months recurrence rate of 6.1%. Major bleeding occurred in 1.9% at 6 months follow-up.

In this study, we performed a meta-analysis on how the incidence of developing HCC is increasing in the cirrhotic state due to the various liver diseases, and compared with that in the non-cirrhotic state.

Our study suggested the possibility that in China, where smoking prevalence is still high, continued smoking was associated with high QOL scores. The phenomenon may be obscured by some potential reasons, including subjectivity of questionnaire, Chinese special culture of tobacco use, and much more. The results reminded researchers and clinicians some underlying situations among smokers in China and prompted a strong call for the implementation of a comprehensive tobacco-control policy and specific public health educational strategies among not only lung cancer survivors but other types of cancer.

Although there are huge differences in the tumor characteristics and treatment modalities of SCCE between Chinese and U.S. patients, the prognosis of SCCE is equally poor in both. Surgery should be considered for patients with localized disease, while chemoradiotherapy is recommended for patients with regional and extensive disease. This study will be helpful to guide the treatment of SCCE in the future.

Early adequate tumor volume response (TVR) does not predict outcome, so modification of chemotherapy in case of an inadequate early TVR may not be justifiable. However, late adequate TVR and poor histological response were independent predictors of adverse outcome; therefore, patients with late-phase inadequate TVR might benefit from augmented treatment.

A multi-faceted intervention tested in five cancer centers using the transparency of race-specific data feedback, real-time warnings derived from EHRs, and patient-centered navigation improved care for both Black and White patients while reducing racial differences. Application of this system-based, pragmatic approach at a health system level could have positive effects on treatment completion, equity and overall outcomes.

ARDI >90% can determine overall survival better than IPI. Favorable ARDI seems to be dependent on efficient neutropenia prophylaxis and cardiac protection

In this work, we characterized the proteins loaded in exosomes isolated from the serum of African American prostate cancer patients and identified a novel protein signature.

Increased PD-L2 expression in tissue specimens could serve as diagnostic parameter for OSCC. Local PD-L2 expression in OSCC might contribute to tumor immune escape additionally to PD-L1. Increased PD-L1—but not PD-L2—in peripheral blood is associated with inferior survival in OSCC patients.

Our study indicates that circRNAs may serve as promising indicators for prognostic and diagnostic evaluation of patients with hepatocellular carcinoma.

In the present study, we conducted high-throughput luciferase reporter screening to discover new Keap1/Nrf2 pathway inhibitors. From our screening, the novel compound K-563 was isolated from the culture broth of Streptomyces sp. 3728-17 and was found to selectively inhibit the reporter activity of the Keap1/Nrf2 pathway. Furthermore, K-563 inhibited the expression of Keap1/Nrf2 pathway downstream proteins, GSH synthesis and ROS resistance through the suppression of the Keap1/Nrf2 pathway downstream gene expression.

Our paper presents a conceptual advance of developmental and cell biology by revealing the conserved nuclear envelop and histone dynamic changes in human and mouse terminal erythropoiesis. We find that patients with myelodysplastic syndrome (MDS) exhibited significant defects in histone release in the dysplastic erythroblasts. Our results indicate that disruption of the histone release process plays a critical role in the pathogenesis of dyserythropoiesis in MDS.

Our findings have demonstrated that PTGS2 influenced radiotherapy tolerance of U87 cells through the NF-κB signaling pathway. Importantly, we demonstrated that this pathway promoted the resistance to IR, which was a finding with important therapeutic implications for human glioma.

To improve treatment of BRAF/MEK inhibitors and chemotherapy in BRAF/NRAS mt melanoma, the benefit of the plant-derived compound magnolol alone or in combination has been investigated. Magnolol decimated BRAF/NRAS mt cancer cells alone or in combination albeit at a lower dosage than magnolol alone. Mechanistically, magnolol-induced cell death in BRAF/NRAS mt melanoma through PI3K/Akt dependent epigenetic remodeling.

We demonstrated that miR-130a-3p suppresses the activation of TGF-β/SMAD4 signal-induced EMT and the invasion and migration in EC-1 cell lines by targeting SMAD4.

This study reveals that a low HDL-C level in stage II/III CRC patients predicts poor prognosis. The correlation between the HDL-C level and immune signature in tissue specimens supports the hypothesis that HDL-C is likely to play an inhibitory role in tumour development via affecting immune responses.

Circulating free DNA (cfDNA) has high concordance rate in detecting KRAS mutation status in colorectal cancer (CRC) patients, compared with tumor tissues. cfDNA has adequate diagnostic performance and could act as an effective method to detect KRAS mutation status in CRC patients. Due to its high specificity and non-invasive nature, cfDNA might be a promising screening tool for CRC.

In the present study, we have provided convincing evidence in vitro and in vivo demonstrating that Nr5a2 can induce lung cancer stem cells (CSC) properties and promote tumorigenesis and progression through transcriptional up-regulation of Nanog.

Resveratrol alleviates DOX-resistance in breast cancer cells. Resveratrol reverses EMT properties. Resveratrol modulates SIRT1/β-catenin signaling pathway.

HER2-targeted therapy, especially the anti-HER2 antibody trastuzumab, is standard for HER2-positive breast cancer; however, its efficacy is limited in a subpopulation of patients. The current study found that blockade of HER2 and HER3 using pertuzumab and patritumab could overcome resistance to trastuzumab therapy in heregulin-expressing and HER2-positive breast cancer, which could be exploited clinically.

The ERBB2 oncogene hypothesis is challenged in hepatocellular carcinoma (HCC) with the conflicting evidences of human epidermal growth factor receptor 2 (HER2) overexpression. Our results showed that HER2 expression pattern is linked with tumor stage and overall survival; the transforming function of HER2 is found more relevant through β-catenin and SMAD3. HER2-targeted treatment is indicated to suppress the HER2-mediated tumor growth during postoperative liver regeneration.

CD9 is an interesting marker to discriminate hematopoietic stem cells from leukemic stem cells

Two methods, Venice criteria and false-positive report probability (FPRP) tests, were used to grade cumulative evidence of significant associations between genetic polymorphisms and esophageal cancer susceptibility. At last, five variants with strong evidence on five genes, including CYP1A1 (rs1048943), EGF (rs444903), HOTAIR (rs920778), MMP2 (rs243865) and PLCE1 (rs2274223), moderate for 10 SNPs and weak for 18 SNPs.

Despite literature describing the geographic and sociodemographic distribution of cancer genetic testing, work focused on cancer genetic counseling is limited and contradictory. Using data from the 2015 National Health Survey, genetic counseling appears to be accessed by individuals of diverse racial/ethnic backgrounds, with various insurance coverage and educational levels, and across broad age ranges and geographic regions with sex being the only factor that independently predicted receipt of counseling across both the affected and unaffected populations.

We posited that targeting Cancer Stem Cells with broader immune-based therapeutic methods may be a more potent alternative for eradicating these problematic cells.

We propose CD4+ naive/memory ratio as a novel prognostic biomarker for APC. In addition, CD8+ naive/memory ratio can be a candidate marker for predicting PFS and the change of its level may reflect the progression of APC.