We successfully established two nomograms predicting overall survival(OS) and cancer-specific survival(CSS) of OSCC patients collected from SEER database. The validation results of the nomograms through the concordance index (C-index) and calibration curves showed that the model were credible, which can assist surgeons in developing a more effective therapeutic regimen and conducting personalized prognostic evaluations.

Little is known about the role of primary lymph node sites in survival in Hodgkin lymphoma (HL). This study uses a huge population-based cohort using the SEER database. It was found that intra-abdominal LN sites predict the worst survival in HL patients and that pelvic LN sites were the most aggressive in predicting HL-specific 1-year mortality, and hence, we recommend that primary LN sites be added to future international prognostic scores for HL.

The results of this study indicate that CYP2C8, CYP2C9, and CYP2C19 present potential serum biomarkers for the early diagnosis of HCC. Combination analysis showed significant interactions that were better prognostic indicators of HCC.

The currently available evidence shows that whole-brain radiotherapy (WBRT) plus temozolomide increases the overall response rate in patients with brain metastases of non-small-cell lung cancer compared with WBRT alone.

Adolescents and young adult (AYA) patients have had lower clinical trial accruals over the past few decades and this has led to fewer survival benefits when comparing these patients to children and older adults with cancer. Here we report nearly 1 out of 5 AYA melanoma patients enrolled on trials during the past decade when these trials improved survival substantially.

Timing of CIN could be used as a potential prognostic biomarker in advanced gastric cancer patients undergoing first-line chemotherapy with XELOX.

Ku80 could be used as a diagnostic biomarker for dysplasia, carcinoma in situ, and ESCC. Ku80 overexpression is an independent indicator for survival of superficial ESCC patients. Silencing of Ku80 inhibits malignant behavior of ESCC cells.

Twenty lncRNAs, 10 miRNAs, and 54 mRNAs, which are associated with the prognosis of CM, were conducted the competing endogenous network based on their regulation relationship. Squares represent miRNAs, balls represent mRNAs, and balls with a green circle around represent lncRNAs. Red means upregulated genes, while blue means downregulated genes.

Stromal cell atypia was an independent prognostic factor for recurrence-free survival (RFS) in the low-risk breast phyllodes tumors. Surgical approach and tumor border were independent prognostic factors for RFS in the high-risk breast phyllodes tumors. We made a nomogram based on comprehensive consideration of the histological type, tumor border, tumor residue, mitotic activity, and degree of stromal cell hyperplasia and atypia. It could well predict the RFS probability of breast phyllodes tumors patients.

To our knowledge, this report is the first study of ibrutinib in a predominantly Asian population of patients with relapsed/refractory CLL/SLL and the first to compare ibrutinib with rituximab. Our results show that ibrutinib significantly improved progression-free survival, overall response rate, and overall survival compared with rituximab. Ibrutinib displayed a manageable safety profile with no new or unexpected events reported. These findings are consistent with previous studies of single-agent ibrutinib and demonstrate the efficacy and safety of ibrutinib in a predominantly Asian population of patients.

s-OSCC exhibits poorer OS, DSS, and LRFS as compared to p-OSCC. Bmi1 is upregulated in s-OSCC, as well as in early-stage alteration in a rat model and HaCaT cells, suggesting its possible involvement in s-OSCC initiation and progression.

Current evidence about the association between pioglitazone and bladder cancer risk remains inconsistent. This meta-analysis of two randomized controlled trials and 20 observational studies showed that use of pioglitazone might increase risk of bladder cancer. Our findings suggest a close monitoring of bladder cancer in patients with long-term and high-dose exposure to pioglitazone.

Proteomics identified proteins significantly associated with bone metastasis (BM). Online databases and clinical data verified potential predictive and diagnosis biomarkers. The values for drug development and treatment of lung adenocarcinoma with BM.

Elderly nasopharyngeal carcinoma patients with Charlson Comorbidity Index (CCI) score of 0 had significantly higher 5-year overall survival (OS) than patients with a CCI score of 1 or >2 (53.1% vs. 42.2% vs. 32.9%, P < 0.0001). In multivariate analysis, comorbidity was a statistically significant independent prognostic factor for OS in the elderly NPC patients.

The analysis of a national hospital database allowed the analysis of 1890 incident malignant pleural mesothelioma managed in France in 2011 and 2012. One- and 2-year survival rates were 64% and 48%, respectively. Median survival was 14.9 months. The mean cost per patient was 27,624 ± 17,263 euros After adjusting to age, sex, and co-morbidities, social deprivation index was not significantly associated with survival but living in Rural/semi-rural area was associated with better 2-year survival (HR: 0.83 [95% CI: 0.73–0.94]; P < 0.01).

EBV DNA represents a dynamic biomarker for monitoring treatment and predicting survival in NPC. Assessing plasma EBV DNA before, during, and after chemoradiotherapy could be clinically valuable and enable selection of patients most likely to benefit from additional therapy and improve assessment of treatment response and disease surveillance.

In this large database analysis, over one-third of patients with early-stage nodular lymphocyte-predominant Hodgkin lymphoma did not receive radiotherapy as a component of initial therapy. The omission of upfront radiotherapy was associated with inferior survival.

We proposed a risk stratification model using clinicopathological and metabolic prognostic factors in stage I and stage II breast cancer patients who underwent surgery without neoadjuvant chemotherapy.

We develop and validate an individualized diagnostic signature in thyroid cancer.

The relationship between survival and tumor location in colon cancer was not straightforward. There is a need for further subdivisions when analyzing the survival difference between right-sided colon cancer (RSCC) and left-sided colon cancer (LSCC). We found that RSCC patients had better prognosis than LSCC in stage II disease or mucinous adenocarcinoma/signet ring cell carcinoma patients.

This is the largest demographics and patterns of care study of pediatric glioblastoma. We found age and tumor location related differences in outcomes that reflect variances in tumor biology and of treatment receipt. Our findings demonstrated improved survival was associated with the use of multimodality treatment, particularly the combination of surgery, radiotherapy, and chemotherapy.

Contrast-enhanced computed tomography images of advanced gastric carcinoma. (A, B) Two contrast enhanced CT images in different patients with advanced SRC. Contrast enhanced CT scan shows diffuse gastric wall thickening with strongly enhancement. The layered and heterogeneous-enhancement pattern is shown. (C) Endoscopic image (same patient in B) of the lesion shows a diffusely infiltrating lesion. (D–F) Fifty-five-year-old man with NSRC. Contrast enhanced CT scan and coronal reconstruction show focal gastric wall thickening mainly of the enhancing thickened inner layer (arrow). The homogeneous-enhancement pattern is shown. Endoscopic image of the lesion shows an ulcer lesion located in the gastric antrum.

In this study, we developed two nomograms to predict postoperative recurrence-free survival (RFS) and overall survival (OS), respectively, after comparisons of the systemic inflammatory/immune cells prognostic scores. The nomogram-predicted probability of RFS was associated with peritumoral necroinflammatory activity scores. The proposed nomograms included NMLR had accurate prognostic prediction in patients with HCC after curative hepatectomy.

Racial disparities in cancer mortality still exist despite improvements in treatment strategies leading to improved survival for many cancer types. Data from SEER 2010–2014 were utilized to assess racial/ethnic differences in site of de novo metastasis and relative survival associated with de novo metastasis by race/ethnicity. In conclusion, de novo metastasis is a major contributor to cancer mortality among patients with cancer in the USA.

We found that individuals carrying the AA or AC/AA genotype had a decreased CRC susceptibility compared with the CC genotypes(OR = 0.54, 95% CI = 0.37–0.79 for AA vs. CC, in co-dominant model; OR = 0.82, 95% CI = 0.68–0.99 for AC/AA vs. CC, in dominant model). It is the first study to investigate the association between rs2682818 and CRC susceptibility and this finding could be a meaningful hint for further relevant studies.

The trend that excess risk of secondary primary cancers was consistent among different subgroups of young CRC. More than half of young patients were died due to their secondary malignancies.

Our comprehensive study investigates ethnicity (nine different groups), marital status, treatment factors, standard histopathologic prognostic variables, and economic factors to see whether ethnicity is related to presentation or outcomes in lung cancer. We demonstrate that disparities in income, marriage, and insurance rather than ethnicity affect the survival of patients with lung cancer.

Circulating pretreatment albumin to fibrinogen ratio was a promising prognostic biomarker of NSCLC. According to AFR, stage II–III NSCLC patients were received suitable therapeutic method and the predicted efficacy of nomogram was improved for NSCLC receiving chemo-radiotherapy.

Glioblastoma-activated pericytes develop an immunosuppressive phenotype, reducing T-cell activation through the induction of an anti-inflammatory response. Pericytes support glioblastoma growth in vitro and in vivo.

The cholesterogenic committing step enzyme (HMGCR) is not important in GCa patients, which explain the failure of statins in GCa clinical trials. However, the mitochondrial acetyl-CoA producer (ACSS3), and lower-mevalonate lipidomes are biosignatures for GCa progression. Interfering ACSS3 expression could almost abolished GCa cell growth under starvation stress. This study suggesting a targeting value of ACSS3 for GCa therapy.

CA1 promoted CREB1 expression by regulating miR-590-3p expression in gastric cancer

Both ERCC1 rs3212986 and MLH3 rs108621 also showed an increased risk of CRC. MLH3 rs108621 may be associated with the risk of CRC due to the effect of miR-193a-3p on MLH3, which reminded the possibility as potential susceptibility biomarkers to predict the risk of CRC.

PI3K/Akt signaling pathway was activated in EBV-associated lymphoma cell lines. Treatment with duvelisib, inhibitor of PI3Kγ and PI3Kδ, induced both apoptosis and cell-cycle arrest in EBV-associated B cell lymphoma cell lines, suggesting that duvelisib has therapeutic potential.

We found no significant BRCA1/2 mutations in the cholangiocarcinoma (CCA) cell lines (QBC939, TFK-1 and HuH28). The degree of radiosensitization is dependent on the doses of olaparib and radiation. Our findings emphasize the role of olaparib in radiosensitization of CCA cells.

We demonstrated that DCK knockout by genome editing with a CRISPR-Cas9 system in an Ara-C-sensitive-ALL cell line induced resistance to Ara-C and clofarabine, a second-generation deoxyadenosine analog, and that higher DCK expression was associated with higher AraC sensitivity in a series of B-cell precursor ALL (BCP–ALL) cell lines. In contrast, sensitivity to clofarabine was only marginally associated with DCK gene expression level, suggesting the high antileukemic potential of clofarabine may overcome low DCK expression in Ara-C-resistant BCP–ALL.

RNF144A is epigenetically silenced in breast cancer cells by promoter hypermethylation and MBD4.

Knockdown of PC4 increased radiosensitivity in NSCLC. PC4 regulated XLF expression by transcriptionally suppressing XLF. PC4 was an independent predictor for progression-free survival of patients with NSCLC

We demonstrate that immune enhancement plays a key role in low-dose radiation (LDR)-induced tumor inhibition. Our findings emphasize the importance of immune response in tumor radiotherapy and may help promote the application of LDR as a novel approach in clinical practice.

In this case-control study of well-characterized breast cancer patients, we confirm ATM, CHEK2, PALB2, CDH1, and TP53 as BC risk genes, no association was observed for NBN. We demonstrate a significant association of deleterious variants in the CHEK2, PALB2, and TP53 genes with bilateral BC and both, ATM and CHEK2, were negatively associated with TNBC and (ER)-negative tumor phenotypes. Our study confirmed the benefit of multi-gene testing for risk assessment in BC families while clinical phenotypes associated with non-BRCA1/2 gene mutations remain to be determined.

Chemotherapy can induce terminal skeletal muscle differentiation in WT1-mutant Wilms tumors. However, chemotherapy can result in the evolution of genetically aberrant cells conferring resistance.

Apoptin-derived peptide (AdP) is an antitumor polypeptide constructed in our laboratory that has been used to combat cisplatin (CDDP) resistance in GC cells. AdP exerted a specific cytotoxic effect on GC cells and CDDP-resistant GC cells, and suppressed invasion and migration. AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) within the PI3K/AKT/ARNT signaling pathway.

This study analyzes 61 pediatric/adolescent/young adults (<25 years) with localized synovial sarcoma prospectively enrolled in the European EpSSG-NRSTS05 protocol to demonstrate that somatic genomic index (GI) analyzed using comparative genomic hybridization had a high prognostic value in pediatric synovial sarcoma as an independent prognostic factors. It demonstrates that patients with tumor harboring high GI had worse five-year event-free and metastatic-free survivals comparing to ones with no genomic instability, and that therefore GI could be used to stratify more accurately patients in the future.

We first time determined the role of miR-641 on the erlotinib resistance development in NSCLC cells. Our findings suggest that upregulated expression of miR-641 was significantly associated with erlotinib resistance development in NSCLC cells. Our findings may also aid in the development of potential therapeutics for the treatment of erlotinib-resistant NSCLC.

Our study demonstrates that MALAT1 knockdown reverses TMZ resistance by up-regulating miR-101 regulatory network. And, our findings indicate that MALAT1 may be a prognostic molecular marker and potentional target for GBM TMZ-based chemotherapy.

Oxaloacetate induces apoptosis of HepG2 cells via inhibition of glycolysis in vivo and in vitro. OA inhibits glycolysis via enhancement of OXPHOS in HepG2 cells. OA inhibits glycolysis-related enzyme expression by suppression of the Akt/HIF pathway in HepG2 cells.

We have developed a novel EGFR inhibitor YL143, which displayed highly potent, specific EGFRT790M inhibition and improved the oral bioavailability. YL143 also exhibited antiproliferative effect in H1975 cells and animal xenografts. YL143 may serve as a new promising lead compound for drug discovery overcoming the acquired resistance of patients with NSCLC without adverse toxicities.

Adrenocortical carcinoma (ACC) is a rare malignancy and CTNNB1 is frequently mutated in ACC. Nutlin-3a, an MDM2 inhibitor, was significantly sensitive in cells with CTNNB1 mutation. Nutlin-3a potently inhibited ACC with CTNNB1 mutation.

While physical activity has been associated with lower risk of developing liver cancer, most studies assess physical activity only at a single point in time, often in midlife. Our findings that, compared to individuals who reported little activity over the life course, only sustained physical activity was associated with lower liver cancer risk, offer support for federal recommendations to maintain physical activity both as a young and as an older adult.

A simple two-step screening scheme was established to improve the PPV of the screening, with the combination of EBNA1/IgA and VCA/IgA in the first step of screening and anti-EAs in the second step. The PPV could be increased from 4.69% in the first step of screening to 18.52% after the second step of screening. With this two-step serological screening, more people could be benefited from the screening program.

We examined occupation, industry, prostate cancer, and patterns of prostate cancer rates using a large Canadian worker cohort. Increased risks were observed in white-collar, agriculture, and protective services occupations, and decreased risks were observed in construction and transportation occupations across men aged 25–74 years. These findings emphasize the need for further study of job-related exposures and the potential influence of non-occupational factors such as screening behaviours.

The international trends between 1973 and 2007 showed that ASRs of lung cancer among males were declining in 13 of 18 selected Americas, Oceania, and Europe populations, with AAPC from −0.7% to −2.9%. Whereas the rates among females in 18 selected populations were increasing, with AAPC from 1.3% to 5.0%. The increasing and decreasing trends of ASRs of lung cancer in Asia have an geographic variation but no gender differences.

Cancer disparities in rural and frontier communities are an important issue in Utah because much of Utah is sparsely populated. Patients with cancer from rural counties in Utah were more likely to be older, American Indian/Alaskan Native, non-Hispanic, male, and diagnosed at higher stage. Rural residents had a five-year relative survival that was 5.2% lower than metropolitan residents and a 10% increase in risk of death (HR = 1.10, 95% CI = 1.03, 1.18) after adjustment for multiple factors.

This is the first population-based study in Switzerland investigating socioeconomic and demographic inequalities in stage at diagnosis and survival among patients with colorectal cancer (CRC). This study describes high-risk groups for later stage CRC diagnosis (patients with low SEP) and poorer disease-specific survival (non-Swiss and patients living in nonurban areas). Swiss public health strategies should facilitate equal access to CRC screening and optimal CRC care for all social groups and in all regions of Switzerland.

In this longitudinal cohort study that included 209 patients with late-stage cancers, patients were over two-and-a-half times as likely to report that their disease was late-stage if an oncologist was present versus not present for their scan results discussion in clinic. Our findings suggest that it is important for oncologists to be present during clinic visits in which scan results are discussed for patients to understand their cancer is at a late-stage.

Our novel findings are that (1) WHR, lesion diameter >2 cm, myometrial invasion ≥50%, pathological grade, and insulin levels were significant predictors of LNM risk in both premenopausal and postmenopausal women, (2) insulin level with a cut-off of 10.48 μIU/mL was predictive of LNM risk when adjusted for BMI (OR: 3.51, 1.42–5.98; P < 0.05) or WHR (OR: 1.87, 1.08–2.66; P < 0.05) in premenopausal women, and (3) insulin with a similar cut-off of 10.15 μIU/mL was predictive of LNM risk when adjusted for BMI (3.07, 1.26–5.40; P < 0.05, respectively) or WHR (OR: 1.61, 1.04–2.35; P < 0.05).

In this study, we found a moderate association between not having a low birthweight and an increased risk of acute leukemias. Birthweight ≥3500 g was also a risk factor for both types of leukemia. This suggests that a greater birthweight may increase the risk of acute leukemias in Mexican children.

By investigating the population-based cancer survival from 2003 to 2013 in one of the high-risk areas of upper gastrointestinal cancer in China, here is an increase trend on upper gastrointestinal cancer survival overall with the early detection, screening, and treatment of cancer in Cixian.

Our study here demonstrated for the first time that Traditional Chinese Medicine CFF-1 selectively induced prostate cancer cell growth inhibition, autophagy, and apoptosis by competitively targeting EGFR with EGF and then inhibited EGFR-related signal pathways in vitro and in vivo.

The efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma was confirmed by comparing to the Bone and Soft Tissue Tumor Registry in Japan (BSTT). RHC resulted in a high local control at 5 years compared to the BSTT group, and the difference in overall survival was not significant between groups.