First-line with maintenance therapies have shown benefits in selected advanced NSCLC populations. Here, first-line with maintenance treatments are compared within patient groups and clinically meaningful benefits are shown for particular first-line with maintenance therapies in selected patients.

The predisposing factors of an unscheduled admittance and a metabolic imbalance accurately predict the development of delirium in patients with cancer (delirium risk 1:3). This prediction algorithm for delirium that can be easily implemented in daily clinical practice should be evaluated for the potential benefit of preventive treatment of patients with cancer who are prone to develop delirium.

Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy.

Time-dependent effects on survival indicated that prognostic factors of colorectal cancer had changeable risks as time progressed. Nonlinear modeling detected nonlinear effects and provided more prognosis information. Three-dimensional cumulative incidence curves were used to identify the change points of the risk trends.

Metabolic responses based on FDG-PET assessment. PMR partial metabolic response, SMD stable metabolic disease, PMD progressive metabolic disease. *indicates patients with PMD as defined in .

Patients (n = 100) received periareolar injection of Sonazoid followed by ultrasonography of the axilla for identification of contrast-enhanced sentinel lymph node (SLN). This method is technically simple with a high success rate (98%) and comparable to the conventional method using blue dye and/or radiocolloid.

The rational data on endocrine toxicity of immune checkpoint inhibitors are scarce. It seemed important to us to indicate and discuss some pre- or misconceptions about thyroid dysfunction, hypophysitis, and diabetes induced by immune checkpoint inhibitors, in order to improve the management of patients.

Telomere length was reduced in individuals who developed hepatocellular carcinoma in nonalcoholic fatty liver (NAFLD-HCC) versus those with cirrhosis and healthy controls, independently of age and sex. We detected an enrichment of hTERT mutations in NAFLD patients affected by primary liver cancer, predominantly in females and specifically in the N-terminal template-binding domain. In conclusion, shorter telomeres and enrichment of hTERT rare germline mutations are associated with NAFLD-HCC.

Glycyrrhizin can induce excessive autophagic phenomenon in hepatocellular carcinoma cell lines. Autophagy-mediated cell death is also a credible route of tumor suppression pathway.

Sixty-three human small cell lung cancer cell lines were screened to search for agents which may act synergistically with etoposide/carboplatin. Most third agents were additive or antagonistic with etoposide/carboplatin. Third agents which were synergistic are highlighted.

These results demonstrate that the combination of metformin and pemetrexed has a synergistic effect on the treatment of NSCLC cell lines by inducing apoptosis or blocking the cell cycle. Our data indicate that the combination of metformin and pemetrexed could have beneficial antitumor effects on NSCLC cells in vitro.

In this study, we performed next-generation sequencing profiling on primary colorectal tumor tissues obtained from three CRC patients with liver metastases and three CRC patients without liver metastases to identify differentially expressed genes (DEGs) that might be responsible for the metastases process. The validation showed that three most significantly upregulated DEGs were HOXD10, UGT2A3, and SLC13A2 whereas the five most significantly downregulated DEGs were SPP1, CXCL8, MMP3, OSM, and CXCL6, respectively.

This study demonstrates that telomere shortening in night workers may be a plausible biological mechanism explaining the increased breast cancer risk in workers with long periods of consecutive night shifts. To our knowledge, this is a novel mechanism suggesting telomere shortening as a contributing factor for shift work-related breast cancer risk.

The lower head and neck cancer incidence observed in females versus males may, in part, be explained by endogenous and exogenous estrogen exposures.

The authors describe the challenges that confront cervical cancer screening programs in low-resource settings, including (1) optimizing screening test effectiveness; (2) achieving high screening coverage of the target population; and (3) managing screen-positive women. For each of these challenges, the authors highlight opportunities for efficient and equitable programming based on evidence from mathematical modeling analyses.