Circ_0000520 facilitated the proliferation, migration and invasion and suppressed the apoptosis of triple-negative breast cancer cells by sponging miR-1296 to induce ZFX expression.

2918 PACC patients diagnosed between 1975 and 2016 were identified from the SEER database. We evaluated overall survival (OS) and disease-specific survival (DSS) respectively. Nomograms were constructed based on the identified independent prognostic factors identified by univariate and multivariate Cox regression analysis.

Study flowchat: A total 115 samples of lung tissues were inclued in study, which including 30 cases of benign samples, 20 cases of precancerous lesions and 65 cases of NSCLC lesions for further study.

Immune cells, the key markers of immune cells, and HLA molecules show significantly down-expressed in KEAP1-mutated LUADs. Not only the multiple immune-related biological processes, but also the interaction between chemokines and their receptors have shown KEAP1 mutation could impair the immune pathways. KEAP1-wild type LUADs favored better overall survival after immunotherapy.

Serum exosomal piR-hsa-26925 and piR-hsa-5444 had a significantly higher level in LUAD patients than those of healthy controls. We established a 2-piRNA panel composed of piR-hsa-26925 and piR-hsa-5444, which showed higher diagnostic performance for LUAD with an AUC of 0.833. In summary, this study suggested that serum exosomal piRNAs could be used as potential biomarkers for the diagnosis of LUAD.

Thisretrospective analysis evaluated the prognostic role of the preserved ratioimpaired spirometry (PRISm). The patients with PRISm had shorter overallsurvival period than those with chronic obstructive pulmonary disease (COPD) ornormal lung function in both NSCLC and SCLC groups.

This study analyzed the case-volume effect on postoperative outcomes after esophagectomy using the most recent data retrieved from National Healthcare Insurance Service database of Korea. Centers with lower case-volume of esophageal cancer surgery showed higher in-hospital mortality and long-term mortality after esophageal cancer surgery.

The burden of thyroid cancer varies in 204 countries and territories from 1990 to 2019. The global incidence of thyroid cancer (a) has increased significantly, while the mortality (b) and DALYs (c) have decreased in the past three decades.

We present a case of lung adenocarcinoma with a novel ROS1-CD74 fusion variant, CD74 exon 3 fused to ROS1 exon 34, which was not detected by a conventional RT-PCR-based testing but identified by hybrid capture-based next-generation sequencing. This tumor responded to crizotinib initially and to entrectinib after relapse with brain metastasis, indicating the oncogenic activity of this novel fusion variant.

For advanced lung cancer, the genome profiling test by minimally invasive liquid biopsy (LB) is gathering attention. Herein, we showed three cases who received target therapy based on LB. LB assisted in diagnosing EML-ALK fusion-positive lung cancer in case 1, detected resistance genes for ALK inhibitor, ALK E1210K and F1174C in case 2, and detected uncommon EGFR mutations that could not be detected by a conventional test in case 3. In these cases, target therapy based on genome profiling resulted in a favorable therapeutic effect.

Lung adenocarcinoma was diagnosed in this patient who subsequently received carboplatin, pemetrexed and pembrolizumab. The carcinomatous lymphangiomatosis improved. Autopsy revealed the tumor was primary salivary gland-type lung adenocarcinoma.

We herein report a rare case of primary pulmonary low-grade fibromyxoid sarcoma. LGFMS could be considered a differential diagnosis of solitary lung mass in young adults. While definitive diagnosis for LGFMS is challenging, MUC4 is useful for definitive diagnosis in patients with FUS wild type.