The GAP model, which is widely used in grading patients with IPF, was externally validated in this study. After comprehensive analysis, the GAP model overestimated the mortality rate in a low-risk group of Chinese patients with IPF. We modified the GAP model to make it more suitable in China.

Bronchiectasis patients usually suffer recurrent respiratory infections, and lung function is damaged progressively. It is not rare in China but is not well understood. Through the 10-year retrospective multicenter study, we initially found the etiology spectrum and clinical characteristics of bronchiectasis in Chinese children.

Participant participation flow chart.

Thoracoscopic lobectomy, thoracoscopic wedge resection of the lesion, or thoracoscopic anatomical segmentectomy can be selected based on a comprehensive analysis of imaging results. Careful and reasonable treatment of the abnormal blood supply artery of the isolated lung is the key to the operation.

ECMO support for immunosuppressed patients remains controversial and challenging. This study provides detailed information on the clinical and laboratory features of these critical patients. Our findings provide insight into the in-hospital mortality has remained high in such patients. Interesting things are, a primarily awake ECMO strategy seems feasible in some selected patients and acute kidney injury requiring CRRT during ECMO treatment may predict ECMO failure in such patients.

NCAPG stimulated LUAD cell stemness through activation of glycolysis pathway. NCAPG may be possible biomarker for diagnosis and target for treatment of LUAD.

M. tuberculosis needs to obtain iron to survive and grow inside its host. M.tuberculosis suppresses ferroportin expression, which increases Fe levels in the phagosome. It also obtains Fe by increasing transferrin receptor (TFR) expression. These conditions cause a decrease in Fe in the blood, and thus anemia occurs. Besides, IFN-gamma, which releases upon immune activation, downregulates the expression of TFR. The ability of NRAMP1 and FPN1 to remove iron from the phagolysosome limits the availability of intracellular iron to intracellular bacteria. Alteration in the NRAMP1 gene may result in a nonfunctional protein or decrease the expression of NRAMP1, leading to more active replication of the bacteria in lung alveolar macrophage. This study demonstrated that TB was associated with decreased NRAMP1 gene, NRAMP1 gene expression was correlated to Fe levels, and TB was associated with low Fe levels. This finding would suggest that TB can lower Fe levels by downregulating NRAMP1 expression.

High-flow nasal cannula is a treatment with high success rate for patients with acute respiratory failure secondary to SARS-CoV-2 pneumonia. This therapy reduces the rates of intubation and mechanical ventilation. It can be used effectively in a conventional hospital ward. In patients not candidates for critical care may also be a suitable treatment option.

The tNGS technique is of great value in the diagnosis and management of C. psittaci pneumonia. A poultry or bird contact history, typical flu-like symptoms, radiographic characteristics such as patchy consolidation, ground-glass density shadow and air bronchogram may contribute to the diagnosis of C. psittaci pneumonia. Moxifloxacin and minocycline are effective in the management of C. psittaci pneumonia.

This cross-sectional study was to develop and validate an efficient and simple clinical diagnostic model to help screen patients at risk of OSAHS. Totally 34 potential predictors were evaluated. The final model has been built with five factors: age, BMI, total bilirubin levels, high Berlin score, and symptom of morning dry mouth or mouth breathing.

Core findings: Our results validated and supported the current T category for the NSCLC patients with bronchus involvements. This study might provide certain reference value for the revisions of T category in the next version of the NSCLC TNM stage classification.

Our results indicate based on the regression equation, 3MSPM can predict 6MWD, and it can be used as a simple exercise endurance method to evaluate patients with safety hazards in underground activities or who cannot complete the 6MWD test. The minimum clinically important difference value is increased by 23.

Pyopneumothorax with bronchopleural fistula is a rare complication of lung infection. We herein report a case of pyopneumothorax with bronchopleural fistula caused by Porphyromonas gingivalis infection, a common pathogenic pathogen of periodontitis, in a 49-year-old man with periodontitis. The patient was admitted with respiratory failure. Pleural puncture yielded a lot of gas continually and foul-smelling light brown pus, which was found to be caused due to infection with P. gingivalis by the next generation sequencing (NGS) and anaerobic culture.

Our understanding of the psychological impact of living with pulmonary hypertension (PH) is growing. Evidence exists for the use of psychological interventions in chronic lung conditions; however, trials involving adults with PH have not been subject to a systematic review. We show that although the evidence is limited, the findings are promising and there is a need for more research.