• Issue

    Journal of Thrombosis and Haemostasis: Volume 20, Issue 7

    i-iv, 1515-1752
    July 2022
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: i-iv
  • First Published: 26 June 2022

EDITORIAL

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ISTH Biennial Impact Report: Looking back and looking forward

Jeffrey I. Weitz,  Flora Peyvandi, 
  • Pages: 1515-1517
  • First Published: 26 June 2022

WTNS

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What the neighbors say

  • Page: 1518
  • First Published: 26 June 2022

NEIGHBORHOOD WATCH

Free Access

Getting smart with coagulation

Emmanuel J. Favaloro,  Leonardo Pasalic,  Giuseppe Lippi, 
  • Pages: 1519-1522
  • First Published: 16 March 2022

REVIEW ARTICLES

Open Access

Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer

Cian Desai,  Milka Koupenova,  Kellie R. Machlus,  Anirban Sen Gupta, 
  • Pages: 1523-1534
  • First Published: 20 April 2022
Open Access

Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation

Shruti Raghunathan,  Julie Rayes,  Anirban Sen Gupta, 
  • Pages: 1535-1549
  • First Published: 18 April 2022
Free Access

The pathobiology of platelet and megakaryocyte extracellular vesicles: A (c)lot has changed

Andrew P. Stone,  Emma Nikols,  Daniela Freire,  Kellie R. Machlus, 
  • Pages: 1550-1558
  • First Published: 04 May 2022

JTH COMMENTARIES

Open Access

Commentary on “Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism”: A new role for plasminogen activator inhibitor-1—An inhibitor of fibrinolysis predicts future venous thromboembolic events and links them to obesity

Johann Wojta, 
  • Pages: 1559-1561
  • First Published: 26 June 2022
Free Access

Commentary on “Risk of venous thromboembolism after COVID-19 vaccination”

Corinne Frere,  Joe-Elie Salem, 
  • Pages: 1562-1564
  • First Published: 26 June 2022
Free Access

The international normalized ratio – Great for prediction of bleeding in patients taking vitamin K antagonists, useless for prediction of bleeding in patients with chronic liver disease

Edoardo G. Giannini,  Ton Lisman, 
  • Pages: 1565-1567
  • First Published: 26 June 2022

JTH IN CLINIC

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JTH in Clinic - Obstetric bleeding: VWD and other inherited bleeding disorders

Jill M. Johnsen,  Hayley J. MacKinnon, 
  • Pages: 1568-1575
  • First Published: 27 May 2022

HAEMOSTASIS

Original Articles

Free Access

Molecular pathogenesis and heterogeneity in type 3 VWD families in U.S. Zimmerman program

Pamela A. Christopherson,  Sandra L. Haberichter,  Veronica H. Flood,  Crystal L. Perry,  Brooke E. Sadler,  Daniel B. Bellissimo,  Jorge Di Paola,  Robert R. Montgomery,  the Zimmerman Program Investigators , 
  • Pages: 1576-1588
  • First Published: 28 March 2022
Free Access

Increased cleavage of von Willebrand factor by ADAMTS13 may contribute strongly to acquired von Willebrand syndrome development in patients with essential thrombocythemia

Masayuki Kubo,  Kazuya Sakai,  Masaki Hayakawa,  Hirokazu Kashiwagi,  Hideo Yagi,  Yoshinobu Seki,  Atsushi Hasegawa,  Haruyuki Tanaka,  Itsuto Amano,  Yoshiaki Tomiyama,  Masanori Matsumoto, 
  • Pages: 1589-1598
  • First Published: 30 March 2022
Free Access

von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient-derived endothelial colony-forming cells

Mackenzie Bowman,  Lara Casey,  Soundarya N. Selvam,  Patricia D. A. Lima,  Orla Rawley,  Megan Hinds,  Angie Tuttle,  Julie Grabell,  Alfonso Iorio,  Irwin Walker,  David Lillicrap,  Paula James, 
  • Pages: 1599-1609
  • First Published: 25 April 2022
Free Access

Different risks of hemorrhage in patients with elevated international normalized ratio from chronic liver disease versus warfarin therapy, a population-based retrospective cohort study

Amber Afzal,  Brian F. Gage,  Luo Suhong,  Martin W. Schoen,  Kevin Korenblat,  Kristen M. Sanfilippo, 
  • Pages: 1610-1617
  • First Published: 01 May 2022

THROMBOSIS

Original Articles

Open Access

Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism

Tobias Frischmuth,  Kristian Hindberg,  Pål Aukrust,  Thor Ueland,  Sigrid K. Brækkan,  John-Bjarne Hansen,  Vânia M. Morelli, 
  • Pages: 1618-1626
  • First Published: 15 March 2022
Free Access

Endothelial-derived von Willebrand factor accelerates fibrin clotting within engineered microvessels

Samuel G. Rayner,  Zackary Scholl,  Christian J. Mandrycky,  Junmei Chen,  Karina N. LaValley,  Peter J. Leary,  William A. Altemeier,  W. Conrad Liles,  Dominic W. Chung,  José A. López,  Hongxia Fu,  Ying Zheng, 
  • Pages: 1627-1637
  • First Published: 28 March 2022
Free Access

Risk of venous thromboembolism after COVID-19 vaccination

Damon E. Houghton,  Waldemar Wysokinski,  Ana I. Casanegra,  Leslie J. Padrnos,  Surbhi Shah,  Ewa Wysokinska,  Rajiv Pruthi,  Aneel Ashrani,  Meera Sridharan,  Lisa Baumann-Kreuziger,  Robert McBane,  Anand Padmanabhan, 
  • Pages: 1638-1644
  • First Published: 10 April 2022
Open Access

Venous thrombosis risk during and after medical and surgical hospitalizations: The medical inpatient thrombosis and hemostasis (MITH) study

Ximena Jordan Bruno,  Insu Koh,  Pamela L. Lutsey,  Robert F. Walker,  Nicholas S. Roetker,  Katherine Wilkinson,  Nicolas L. Smith,  Timothy B. Plante,  Allen B. Repp,  Chris E. Holmes,  Mary Cushman,  Neil A. Zakai, 
  • Pages: 1645-1652
  • First Published: 15 April 2022
Free Access

Antithrombotic potential of a single-domain antibody enhancing the activated protein C-cofactor activity of protein S

Josepha C. Sedzro,  Frédéric Adam,  Claire Auditeau,  Elsa Bianchini,  Allan De Carvalho,  Ivan Peyron,  Sadyo Daramé,  Sophie Gandrille,  Stella Thomassen,  Tilman M. Hackeng,  Olivier D. Christophe,  Peter J. Lenting,  Cécile V. Denis,  Delphine Borgel,  François Saller, 
  • Pages: 1653-1664
  • First Published: 21 April 2022
Open Access

Incidence and determinants of thrombotic and bleeding complications in patients with glioblastoma

Fleur H. J. Kaptein,  Milou A. M. Stals,  Maaike Y. Kapteijn,  Suzanne C. Cannegieter,  Linda Dirven,  Sjoerd G. van Duinen,  Ronald van Eijk,  Menno V. Huisman,  Eva E. Klaase,  Martin J. B. Taphoorn,  Henri H. Versteeg,  Jeroen T. Buijs,  Johan A. F. Koekkoek,  Frederikus A. Klok, 
  • Pages: 1665-1673
  • First Published: 23 April 2022
Open Access

Efanesoctocog alfa elicits functional clot formation that is indistinguishable to that of recombinant factor VIII

Melanie Demers,  Maria M. Aleman,  Elena Kistanova,  Robert Peters,  Joe Salas,  Ekta Seth Chhabra, 
  • Pages: 1674-1683
  • First Published: 25 April 2022
Open Access

First randomized evaluation of safety, pharmacodynamics, and pharmacokinetics of BAY 1831865, an antibody targeting coagulation factor XI and factor XIa, in healthy men

Bettina Nowotny,  Dirk Thomas,  Stephan Schwers,  Sara Wiegmann,  Wolfgang Prange,  Ashraf Yassen,  Stefanie Boxnick, 
  • Pages: 1684-1695
  • First Published: 01 May 2022

Case Report

Free Access

Refractory immune TTP following Pfizer-BioNTech COVID-19 vaccine successfully salvaged with caplacizumab

Eva Laverdure,  Catherine Sperlich,  Susan Fox, 
  • Pages: 1696-1698
  • First Published: 05 May 2022

PLATELETS

Original Article

Free Access

Adenosine diphosphate-induced aggregation is enhanced in platelets obtained from patients with thrombotic primary antiphospholipid syndrome (t-PAPS): Role of P2Y12-cAMP signaling pathway

Guilherme Ruiz Leonardi,  Caroline Honaiser Lescano,  Jose Luiz Costa,  Bruna Mazetto,  Fernanda Andrade Orsi,  Fabiola Zakia Monica, 
  • Pages: 1699-1711
  • First Published: 08 April 2022

Brief Report

Free Access

Platelet VPS16B is dependent on VPS33B expression, as determined in two siblings with arthrogryposis, renal dysfunction, and cholestasis syndrome

Monica Penon-Portmann,  Sarah K. Westbury,  Ling Li,  Fred G. Pluthero,  Richard J. Y. Liu,  Helen H. Y. Yao,  Ryan S. Q. Geng,  Neil Warner,  Aleixo M. Muise,  Stephanie Lotz-Esquivel,  Marianela Howell-Ramirez,  Pablo Saborío-Chacon,  Sara Fernández-Rojas,  Manuel Saborio-Rocafort,  Mildred Jiménez-Hernández,  Carolina Wang-Zuniga,  Walter Cartín-Sánchez,  Joseph T. Shieh,  Ramses Badilla-Porras,  Walter H. A. Kahr, 
  • Pages: 1712-1719
  • First Published: 24 March 2022

ISTH SSC COMMUNICATIONS

Free Access

Results of an international survey on adherence with anticoagulation in children, adolescents, and young adults: Communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis

Meghan E. McGrady,  Kevin Todd,  Vera Ignjatovic,  Sophie Jones,  Mattia Rizzi,  Lori Luchtman-Jones,  Courtney D. Thornburg, 
  • Pages: 1720-1728
  • First Published: 15 April 2022
Open Access

Recommendations for standardized definitions, clinical assessment, and future research in pediatric clinically unsuspected venous thromboembolism: Communication from the ISTH SSC subcommittee on pediatric and neonatal thrombosis and hemostasis

Marisol Betensky,  Ketan Kulkarni,  Mattia Rizzi,  Sophie Jones,  Leonardo R. Brandão,  Edward Vincent S. Faustino,  Neil A. Goldenberg,  Anjali Sharathkumar, 
  • Pages: 1729-1734
  • First Published: 17 April 2022
Open Access

Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communication from the SSC of the ISTH

Adrian Minford,  Leonardo R. Brandão,  Maha Othman,  Christoph Male,  Rezan Abdul-Kadir,  Paul Monagle,  Andrew D. Mumford,  Dorothy Adcock,  Björn Dahlbäck,  Predrag Miljic,  Maria T. DeSancho,  Jun Teruya, 
  • Pages: 1735-1743
  • First Published: 17 April 2022

LETTERS TO THE EDITOR

Free Access

“A new hemophilia carrier nomenclature to define hemophilia in women and girls: Communication from the SSC of the ISTH”: Comment

Rachel S. Bercovitz, 
  • Pages: 1744-1745
  • First Published: 26 June 2022
Free Access

“A New Hemophilia Carrier Nomenclature to define hemophilia in women and girls: Communication from the SSC of the ISTH”: Reply to comment

Robert F. Sidonio Jr., 
  • Pages: 1745-1746
  • First Published: 26 June 2022
Free Access

“Effect of polypharmacy on bleeding with rivaroxaban versus vitamin K antagonist for treatment of venous thromboembolism”: Comment

Willem M. Lijfering, 
  • Page: 1747
  • First Published: 26 June 2022
Free Access

“Effect of polypharmacy on bleeding with rivaroxaban versus vitamin K antagonist for treatment of venous thromboembolism”: Reply

Ingrid M. Bistervels,  Roisin Bavalia,  Saskia Middeldorp,  Michiel Coppens, 
  • Pages: 1748-1749
  • First Published: 26 June 2022

ANNOUNCEMENTS

Free Access

ISTH News and Updates: Join the ISTH Today

  • Pages: 1750-1752
  • First Published: 26 June 2022