• Issue

    Hepatology: Volume 69, Issue 4

    1365-1848
    April 2019
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Cover Image

  • First Published: 28 March 2019

Issue Information

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Masthead

  • First Published: 28 March 2019
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Table of contents

  • First Published: 28 March 2019

Hepatology Highlights

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Hepatology Highlights

Kavitha M. Nair,  Ravi S. Vora,  Omar Y Mousa,  Harmeet Malhi,  Robert E. Schwartz,  Joseph F. Pisa,  Robert S. Brown Jr.,  Hirsh D. Trivedi,  Daryl T.Y. Lau,  Nicole Shen,  Akhil Shenoy,  Jessica L. Maiers,  Enis Kostallari,  Petra Hirsova,  Nicholas Russo,  Tasha B. Kulai, 
  • Pages: 1365-1368
  • First Published: 28 March 2019

Special Article

Introducing the AASLD President

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Meet Your President: Michael W. Fried, M.D., F.A.A.S.L.D.

Adrian M. Di Bisceglie M.D., F.A.A.S.L.D., 
  • Pages: 1369-1371
  • First Published: 17 January 2019

Editorials

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The Interplay Between Nonalcoholic Fatty Liver Disease and Atherosclerotic Heart Disease

Samarth Siddharth Patel M.D.,  Mohammad Shadab Siddiqui M.D., 
  • Pages: 1372-1374
  • First Published: 05 December 2018
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Targeting Transforming Growth Factor Beta Signaling in Liver Cancer

Shuyun Rao Ph.D.,  Lopa Mishra M.D., 
  • Pages: 1375-1378
  • First Published: 14 December 2018
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Liver Disease in Cystic Fibrosis: Illuminating the Black Box

Carla Colombo M.D.,  Gianfranco Alicandro M.Sc., 
  • Pages: 1379-1381
  • First Published: 06 September 2018
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Interventions for Primary Prevention of Esophageal Variceal Bleeding

Loren Laine M.D., 
  • Pages: 1382-1384
  • First Published: 18 December 2018

Original Articles

VIRAL HEPATITIS

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Prevalence of Undetectable Vaccine-Induced Immunity Against Hepatitis B Virus in US Adults at High Risk for Infection

Yee Hui Yeo,  Michael H. Le,  Ellen T. Chang,  Linda Henry,  Mindie H. Nguyen, 
  • Pages: 1385-1397
  • First Published: 23 September 2018
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PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

Henrik Mueller,  Anaïs Lopez,  Philipp Tropberger,  Steffen Wildum,  Josephine Schmaler,  Lykke Pedersen,  Xingchun Han,  Yongguang Wang,  Søren Ottosen,  Song Yang,  John A.T. Young,  Hassan Javanbakht, 
  • Pages: 1398-1411
  • First Published: 26 October 2018
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Smoking and Hepatitis B Virus–Related Hepatocellular Carcinoma Risk: The Mediating Roles of Viral Load and Alanine Aminotransferase

Ya-Hui Wang,  Ya-Hui Chuang,  Chih-Feng Wu,  Meng-Chin Jan,  Wan-Jung Wu,  Chih-Lin Lin,  Chun-Jen Liu,  Ya-Chien Yang,  Pei-Jer Chen,  Shi-Ming Lin,  Mong-Hsun Tsai,  Yi-Wen Huang,  Ming-Whei Yu, 
  • Pages: 1412-1425
  • First Published: 01 November 2018
Open Access

Highly Diverse Hepatitis C Strains Detected in Sub-Saharan Africa Have Unknown Susceptibility to Direct-Acting Antiviral Treatments

Chris Davis,  George S. Mgomella,  Ana da Silva Filipe,  Eric H. Frost,  Genevieve Giroux,  Joseph Hughes,  Catherine Hogan,  Pontiano Kaleebu,  Gershim Asiki,  John McLauchlan,  Marc Niebel,  Ponsiano Ocama,  Cristina Pomila,  Oliver G. Pybus,  Jacques Pépin,  Peter Simmonds,  Joshua B. Singer,  Vattipally B. Sreenu,  Clara Wekesa,  Elizabeth H. Young,  Donald G. Murphy,  Manj Sandhu,  Emma C. Thomson, 
  • Pages: 1426-1441
  • First Published: 02 November 2018
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The Burden of Chronic Hepatitis C in China From 2004 to 2050: An Individual-Based Modeling Study

Jie Wu,  Yuqing Zhou,  Xiaofang Fu,  Min Deng,  Yang Zheng,  Guo Tian,  Yiping Li,  Chencheng Wang,  Cheng Ding,  Bing Ruan,  Shigui Yang,  Lanjuan Li, 
  • Pages: 1442-1452
  • First Published: 18 December 2018

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Relationship Among Fatty Liver, Specific and Multiple-Site Atherosclerosis, and 10-Year Framingham Score

Raluca Pais,  Alban Redheuil,  Philippe Cluzel,  Vlad Ratziu,  Philippe Giral, 
  • Pages: 1453-1463
  • First Published: 19 August 2018
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Age and Sex but Not ATP7B Genotype Effectively Influence the Clinical Phenotype of Wilson Disease

Peter Ferenci,  Wolfgang Stremmel,  Anna Członkowska,  Ferenc Szalay,  André Viveiros,  Albert Friedrich Stättermayer,  Radan Bruha,  Roderick Houwen,  Tudor Lucian Pop,  Rudolf Stauber,  Michael Gschwantler,  Jan Pfeiffenberger,  Cihan Yurdaydin,  Elmar Aigner,  Petra Steindl-Munda,  Hans-Peter Dienes,  Heinz Zoller,  Karl Heinz Weiss, 
  • Pages: 1464-1476
  • First Published: 19 September 2018
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Predicting Low Risk for Sustained Alcohol Use After Early Liver Transplant for Acute Alcoholic Hepatitis: The Sustained Alcohol Use Post–Liver Transplant Score

Brian P. Lee,  Eric Vittinghoff,  Christine Hsu,  Hyosun Han,  George Therapondos,  Oren K. Fix,  David W. Victor,  Deepti Dronamraju,  Gene Y. Im,  Michael D. Voigt,  John P. Rice,  Michael R. Lucey,  Sheila Eswaran,  Po-Hung Chen,  Zhiping Li,  Haripriya Maddur,  Norah A. Terrault, 
  • Pages: 1477-1487
  • First Published: 18 December 2018
Open Access

LXRα Promotes Hepatosteatosis in Part Through Activation of MicroRNA-378 Transcription and Inhibition of Ppargc1β Expression

Tianpeng Zhang,  Jiangyan Duan,  Lei Zhang,  Zhuoyu Li,  Clifford J. Steer,  Guiqin Yan,  Guisheng Song, 
  • Pages: 1488-1503
  • First Published: 03 October 2018
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17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease

Yanling Ma,  Olga V. Belyaeva,  Philip M. Brown,  Koji Fujita,  Katherine Valles,  Suman Karki,  Ynto S. de Boer,  Christopher Koh,  Yanhua Chen,  Xiaomeng Du,  Samuel K. Handelman,  Vincent Chen,  Elizabeth K. Speliotes,  Cara Nestlerode,  Emmanuel Thomas,  David E. Kleiner,  Joseph M. Zmuda,  Arun J. Sanyal,  (for the Nonalcoholic Steatohepatitis Clinical Research Network) ,  Natalia Y. Kedishvili,  T. Jake Liang,  Yaron Rotman, 
  • Pages: 1504-1519
  • First Published: 11 November 2018
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A Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma

Divya P. Kumar,  Prasanna K. Santhekadur,  Mulugeta Seneshaw,  Faridoddin Mirshahi,  Cora Uram-Tuculescu,  Arun J. Sanyal, 
  • Pages: 1520-1534
  • First Published: 05 November 2018

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Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin-1/Mechanistic Target of Rapamycin Complex 2 and 5′Adenosine Monophosphate–Activated Protein Kinase Signaling

Jie Liu,  Grzegorz Godlewski,  Tony Jourdan,  Ziyi Liu,  Resat Cinar,  Keming Xiong,  George Kunos, 
  • Pages: 1535-1548
  • First Published: 01 December 2018

HEPATOBILIARY DISEASE

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A Transforming Growth Factor-β and H19 Signaling Axis in Tumor-Initiating Hepatocytes That Regulates Hepatic Carcinogenesis

Jinqiang Zhang,  Chang Han,  Nathan Ungerleider,  Weina Chen,  Kyoungsub Song,  Ying Wang,  Hyunjoo Kwon,  Wenbo Ma,  Tong Wu, 
  • Pages: 1549-1563
  • First Published: 16 July 2018
Open Access

Heat Shock Protein 90α–Dependent B-Cell-2–Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto-Oncogene c-MYC mRNA Stability

Xueqiong Zhou,  Ying Wen,  Ye Tian,  Meiling He,  Xiangyu Ke,  Zhizhou Huang,  Yangfan He,  Lixia Liu,  Annette Scharf,  Meiting Lu,  Guowei Zhang,  Yaotang Deng,  Yuxia Yan,  Matthias P. Mayer,  Xuemei Chen,  Fei Zou, 
  • Pages: 1564-1581
  • First Published: 17 July 2018

HEPATOBILIARY MALIGNANCIES

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The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth

Adrian P. Mansini,  Estanislao Peixoto,  Sujeong Jin,  Seth Richard,  Sergio A. Gradilone, 
  • Pages: 1582-1598
  • First Published: 09 October 2018
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Magnetic Resonance Imaging Is Cost-Effective for Hepatocellular Carcinoma Surveillance in High-Risk Patients With Cirrhosis

Hye-Lin Kim,  Jihyun An,  Jae-A Park,  Seung-Hoo Park,  Young-Suk Lim,  Eui-Kyung Lee, 
  • Pages: 1599-1613
  • First Published: 26 October 2018
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Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate–Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice

Yun-Shan Wang,  Lutao Du,  Xingsi Liang,  Peng Meng,  Lei Bi,  Yu-li Wang,  Chuanxin Wang,  Bo Tang, 
  • Pages: 1614-1631
  • First Published: 15 December 2018

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Eva Santamaría,  Carlos M. Rodríguez-Ortigosa,  Iker Uriarte,  Maria U. Latasa,  Raquel Urtasun,  Gloria Alvarez-Sola,  Marina Bárcena-Varela,  Leticia Colyn,  Sara Arcelus,  Maddalen Jiménez,  Kathleen Deutschmann,  Ana Peleteiro-Vigil,  Julian Gómez-Cambronero,  Malgorzata Milkiewicz,  Piotr Milkiewicz,  Bruno Sangro,  Verena Keitel,  Maria J. Monte,  Jose J.G. Marin,  Maite G. Fernández-Barrena,  Matias A. Ávila,  Carmen Berasain, 
  • Pages: 1632-1647
  • First Published: 08 November 2018

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

Open Access

Cystic Fibrosis Liver Disease: Outcomes and Risk Factors in a Large Cohort of French Patients

Pierre-Yves Boëlle,  Dominique Debray,  Loic Guillot,  Annick Clement,  Harriet Corvol,  on behalf of the French CF Modifier Gene Study Investigators , 
  • Pages: 1648-1656
  • First Published: 30 July 2018
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Comparison of Therapies for Primary Prevention of Esophageal Variceal Bleeding: A Systematic Review and Network Meta-analysis

Mayank Sharma,  Siddharth Singh,  Vivek Desai,  Vijay H. Shah,  Patrick S. Kamath,  Mohammad Hassan Murad,  Douglas A. Simonetto, 
  • Pages: 1657-1675
  • First Published: 19 August 2018
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Frailty, Psychoactive Medications, and Cognitive Dysfunction Are Associated With Poor Patient-Reported Outcomes in Cirrhosis

Elliot B. Tapper,  Jad Baki,  Neehar D. Parikh,  Anna S. Lok, 
  • Pages: 1676-1685
  • First Published: 01 November 2018
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Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis

Joan Clària,  Richard Moreau,  François Fenaille,  Alex Amorós,  Christophe Junot,  Henning Gronbaek,  Minneke J. Coenraad,  Alain Pruvost,  Aurélie Ghettas,  Emeline Chu-Van,  Cristina López-Vicario,  Karl Oettl,  Paolo Caraceni,  Carlo Alessandria,  Jonel Trebicka,  Marco Pavesi,  Carme Deulofeu,  Agustin Albillos,  Thierry Gustot,  Tania M. Welzel,  Javier Fernández,  Rudolf E. Stauber,  Faouzi Saliba,  Noémie Butin,  Benoit Colsch,  Christophe Moreno,  François Durand,  Frederik Nevens,  Rafael Bañares,  Daniel Benten,  Pere Ginès,  Alexander Gerbes,  Rajiv Jalan,  Paolo Angeli,  Mauro Bernardi,  Vicente Arroyo,  for the CANONIC Study Investigators of the EASL Clif Consortium, Grifols Chair and the European Foundation for the Study of Chronic Liver Failure (EF Clif) , 
  • Pages: 1686-1701
  • First Published: 06 December 2018

LIVER INJURY/REGENERATION

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TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling

Bharat Bhushan,  John W. Stoops,  Wendy M. Mars,  Anne Orr,  William C. Bowen,  Shirish Paranjpe,  George K. Michalopoulos, 
  • Pages: 1702-1718
  • First Published: 11 June 2018
Open Access

Peribiliary Glands Are Key in Regeneration of the Human Biliary Epithelium After Severe Bile Duct Injury

Iris E.M. de Jong,  Alix P.M. Matton,  Jasper B. van Praagh,  Wouter T. van Haaften,  Janneke Wiersema-Buist,  Louise A. van Wijk,  Dorenda Oosterhuis,  Raditya Iswandana,  Su Suriguga,  Diletta Overi,  Ton Lisman,  Guido Carpino,  Annette S.H. Gouw,  Peter Olinga,  Eugenio Gaudio,  Robert J. Porte, 
  • Pages: 1719-1734
  • First Published: 02 December 2018

LIVER BIOLOGY/PATHOBIOLOGY

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Natural Killer Cell–Derived Interferon-Gamma Promotes Hepatocellular Carcinoma Through the Epithelial Cell Adhesion Molecule–Epithelial-to-Mesenchymal Transition Axis in Hepatitis B Virus Transgenic Mice

Yongyan Chen,  Xiaolei Hao,  Rui Sun,  Haiming Wei,  Zhigang Tian, 
  • Pages: 1735-1750
  • First Published: 17 October 2018
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Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice

Shenhai Gong,  Zhengzheng Yan,  Zhanguo Liu,  Mengwei Niu,  Heng Fang,  Na Li,  Chenyang Huang,  Lei Li,  Guiming Chen,  Haihua Luo,  Xiaojiao Chen,  Hongwei Zhou,  Jingjuan Hu,  Wei Yang,  Qiaobing Huang,  Bernd Schnabl,  Ping Chang,  Timothy R. Billiar,  Yong Jiang,  Peng Chen, 
  • Pages: 1751-1767
  • First Published: 01 December 2018
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Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma

Derek Lee,  Iris Ming-Jing Xu,  David Kung-Chun Chiu,  Josef Leibold,  Aki Pui-Wah Tse,  Macus Hao-Ran Bao,  Vincent Wai-Hin Yuen,  Cerise Yuen-Ki Chan,  Robin Kit-Ho Lai,  Don Wai-Ching Chin,  Daniel For-Fan Chan,  Tan-To Cheung,  Siu-Ho Chok,  Chun-Ming Wong,  Scott W. Lowe,  Irene Oi-Lin Ng,  Carmen Chak-Lui Wong, 
  • Pages: 1768-1786
  • First Published: 18 December 2018

Practice Guidance

Liver Failure, Cirrhosis and Portal Hypertension

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Development of Quality Measures in Cirrhosis by the Practice Metrics Committee of the American Association for the Study of Liver Diseases

Fasiha Kanwal,  Elliot B. Tapper,  Chanda Ho,  Sumeet K. Asrani,  Nadia Ovchinsky,  John Poterucha,  Avegail Flores,  Victor Ankoma-Sey,  Bruce Luxon,  Michael Volk, 
  • Pages: 1787-1797
  • First Published: 26 December 2018

Special Article

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Transplantation for Alcoholic Hepatitis: Are We Achieving Justice and Utility?

Steven F. Solga,  Marina Serper,  Rebecca A. Young,  Kimberly A. Forde, 
  • Pages: 1798-1802
  • First Published: 18 December 2018

Reviews

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Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances

Alphonse E. Sirica,  Gregory J. Gores,  John D. Groopman,  Florin M. Selaru,  Mario Strazzabosco,  Xin Wei Wang,  Andrew X. Zhu, 
  • Pages: 1803-1815
  • First Published: 25 September 2018
Free Access

Serum Hepatitis B Virus RNA: A New Potential Biomarker for Chronic Hepatitis B Virus Infection

Shi Liu,  Bin Zhou,  Juan D. Valdes,  Jian Sun,  Haitao Guo, 
  • Pages: 1816-1827
  • First Published: 25 October 2018

Hepatology Elsewhere

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From Hepatocyte to Cholangiocyte: The Remarkable Potential of Transdifferentiation to Treat Cholestatic Diseases

Binita Kamath M.D.,  Cara Mack M.D., 
  • Pages: 1828-1830
  • First Published: 04 September 2018
Free Access

The Interstitial Space Takes Shape

Prodromos Hytiroglou M.D.,  Ian R. Wanless M.D., C.M., F.R.C.P.C., 
  • Pages: 1830-1832
  • First Published: 14 September 2018
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(Mid)West Side Story: Acute Hepatitis C Virus Infection and the Opioid Epidemic in the United States

Christoph Boesecke M.D.,  Jürgen K. Rockstroh M.D., 
  • Pages: 1832-1834
  • First Published: 25 September 2018

Clinical Observations in Hepatology

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Reversal of Acute Liver Failure Due to Wilson Disease by a Regimen of High-Volume Plasma Exchange and Penicillamine

Jakob Damsgaard,  Fin Stolze Larsen,  Henriette Ytting, 
  • Pages: 1835-1837
  • First Published: 23 October 2018
Free Access

Combined Hepatocellular–Cholangiocarcinoma in a Patient With Cirrhosis Due to Cholesteryl Ester Storage Disease

Graciela Elia Castro Narro,  Armando Gamboa Domínguez,  Alejandra Consuelo Sánchez,  Abel Salazar Martínez,  Jose Agramonte Hevia,  J.J. Cebolla,  Miguel Enrique Cuellar Mendoza,  Héctor Adrián Díaz Hernández, 
  • Pages: 1838-1841
  • First Published: 29 October 2018

Correspondence

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Should LR-M and LR-TIV Remain Separate Categories in LI-RADS?

Myeong-Jin Kim M.D., Ph.D.,  Sunyoung Lee M.D., Ph.D., 
  • Page: 1842
  • First Published: 21 December 2018
Free Access

The Role of Hepatitis B Surface Antigen in Nucleos(t)ide Analogue Cessation Among Asian Chronic Hepatitis B Patients: Friend or Foe?

Chia-Chi Wang M.S.,  Jia-Horng Kao Ph.D., 
  • Page: 1843
  • First Published: 31 January 2019
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Reply

Tao Li M.D.,  Jiaye Liu Ph.D.,  Li Zhang Ph.D.,  Aiqiang Xu Ph.D., 
  • Page: 1844
  • First Published: 31 January 2019
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Letter to Editor: The Synergistic Effect of Albumin on Terlipressin in Acute-on-Chronic Liver Failure With Acute Kidney Injury

Shengtao Lin M.D.,  Da Dorothy Zhang M.B.B.S., B.Sc.,  Yuan Gao M.D.,  Yueke Zhu M.D.,  Bing Hou M.D., 
  • Page: 1845
  • First Published: 31 January 2019
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Reply

Vinod Arora M.D., D.M.,  Rakhi Maiwall M.D., D.M.,  Vijayaraghavan Rajan M.D., D.M.,  Ankur Jindal M.D., D.M.,  Saggere Muralikrishna Shasthry M.D., D.M.,  Guresh Kumar Ph.D.,  Priyanka Jain Ph.D.,  Shiv Kumar Sarin M.D., D.M., 
  • Page: 1846
  • First Published: 31 January 2019
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No Clear Evidence for an Effect of Sofosbuvir Against Hepatitis E Virus in Organ Transplant Patients

Nassim Kamar M.D., Ph.D.,  Qiuwei Pan Ph.D., 
  • Pages: 1846-1847
  • First Published: 05 February 2019
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Reply

Mary Drinane M.D., 
  • Pages: 1847-1848
  • First Published: 08 February 2019

Issue Information

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Notices

  • First Published: 28 March 2019
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Instructions to Authors

  • First Published: 28 March 2019