• Issue

    Hepatology: Volume 62, Issue 4

    985-1330
    October 2015
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Hepatology Highlights

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Hepatology highlights

Jean-François Dufour, 
  • Pages: 985-987
  • First Published: 29 September 2015

Comments from the Editors

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Patient-centered care: A new paradigm for chronic liver disease

Manisha Verma M.D., M.P.H.,  Victor Navarro M.D., 
  • Pages: 988-990
  • First Published: 01 August 2015

Editorials

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When one receptor closes, another opens: Claudins and the hepatitis C virus E1 glycoprotein

Che C. Colpitts PH.D.,  Mirjam B. Zeisel PH.D., PHARM.D.,  Thomas F. Baumert M.D., 
  • Pages: 991-993
  • First Published: 30 April 2015
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Carbohydrate-responsive element-binding protein, Sirtuin 1, and ethanol metabolism: A complicated network in alcohol-induced hepatic steatosis

Suthat Liangpunsakul M.D., M.P.H., 
  • Pages: 994-996
  • First Published: 04 June 2015
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Is liver stiffness measurement to stage fibrosis in patients with nonalcoholic fatty liver disease ready for clinical use?

Michelle Lai M.D., M.P.H., 
  • Pages: 997-998
  • First Published: 20 May 2015
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Natural killer T cells: Novel players in biliary disease?

Marcial Sebode M.D.,  Christoph Schramm M.D., 
  • Pages: 999-1000
  • First Published: 24 April 2015
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Salivary microbiota-immune profiling in cirrhosis: Could this be the noninvasive strategy that will revolutionize prognostication in hepatology?

Vishal C. Patel M.B.B.S.,  Debbie L. Shawcross Ph.D., 
  • Pages: 1001-1003
  • First Published: 22 May 2015

Viral Hepatitis

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Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 in patients with cirrhosis

Bashar A. Aqel,  Surakit Pungpapong,  Michael Leise,  K. Tuesday Werner,  Amy E. Chervenak,  Kymberly D. Watt,  Jennifer L. Murphy,  Kristen Ryland,  Andrew P. Keaveny,  Ryan McLemore,  Hugo E. Vargas, 
  • Pages: 1004-1012
  • First Published: 11 June 2015
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Alisporivir plus ribavirin, interferon free or in combination with pegylated interferon, for hepatitis C virus genotype 2 or 3 infection

Jean-Michel Pawlotsky,  Robert Flisiak,  Shiv K. Sarin,  Jens Rasenack,  Teerha Piratvisuth,  Wan-Long Chuang,  Cheng-Yuan Peng,  Graham R. Foster,  Samir Shah,  Heiner Wedemeyer,  Christophe Hézode,  Wei Zhang,  Kelly A. Wong,  Bin Li,  Claudio Avila,  Nikolai V. Naoumov,  on behalf of the VITAL-1 study team , 
  • Pages: 1013-1023
  • First Published: 27 June 2015
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4′-modified nucleoside analogs: Potent inhibitors active against entecavir-resistant hepatitis B virus

Yuki Takamatsu,  Yasuhito Tanaka,  Satoru Kohgo,  Shuko Murakami,  Kamalendra Singh,  Debananda Das,  David J. Venzon,  Masayuki Amano,  Nobuyo Higashi-Kuwata,  Manabu Aoki,  Nicole S. Delino,  Sanae Hayashi,  Satoru Takahashi,  Yoshikazu Sukenaga,  Kazuhiro Haraguchi,  Stefan G. Sarafianos,  Kenji Maeda,  Hiroaki Mitsuya, 
  • Pages: 1024-1036
  • First Published: 29 June 2015
Open Access

Randomized phase 3 trial of ombitasvir/paritaprevir/ritonavir for hepatitis C virus genotype 1b–infected Japanese patients with or without cirrhosis

Hiromitsu Kumada,  Kazuaki Chayama,  Lino Rodrigues Jr.,  Fumitaka Suzuki,  Kenji Ikeda,  Hidenori Toyoda,  Ken Sato,  Yoshiyasu Karino,  Yasushi Matsuzaki,  Kiyohide Kioka,  Carolyn Setze,  Tami Pilot-Matias,  Meenal Patwardhan,  Regis A. Vilchez,  Margaret Burroughs,  Rebecca Redman, 
  • Pages: 1037-1046
  • First Published: 03 July 2015
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Temporal dynamics of inflammatory cytokines/chemokines during sofosbuvir and ribavirin therapy for genotype 2 and 3 hepatitis C infection

Aaron F. Carlin,  Paula Aristizabal,  Qinghua Song,  Huan Wang,  Matthew S. Paulson,  Luisa M. Stamm,  Robert T. Schooley,  David L. Wyles, 
  • Pages: 1047-1058
  • First Published: 03 July 2015
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Selection of a hepatitis C virus with altered entry factor requirements reveals a genetic interaction between the E1 glycoprotein and claudins

Sharon E. Hopcraft,  Matthew J. Evans, 
  • Pages: 1059-1069
  • First Published: 29 March 2015

Steatohepatitis/Metabolic Liver Disease

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Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

Binxia Chang,  Ming-Jiang Xu,  Zhou Zhou,  Yan Cai,  Man Li,  Wei Wang,  Dechun Feng,  Adeline Bertola,  Hua Wang,  George Kunos,  Bin Gao, 
  • Pages: 1070-1085
  • First Published: 29 May 2015
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Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

Solenne Marmier,  Renaud Dentin,  Martine Daujat-Chavanieu,  Hervé Guillou,  Justine Bertrand-Michel,  Sabine Gerbal-Chaloin,  Jean Girard,  Sophie Lotersztajn,  Catherine Postic, 
  • Pages: 1086-1100
  • First Published: 11 March 2015
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The severity of steatosis influences liver stiffness measurement in patients with nonalcoholic fatty liver disease

Salvatore Petta,  Marcello Maida,  Fabio Salvatore Macaluso,  Vito Di Marco,  Calogero Cammà,  Daniela Cabibi,  Antonio Craxì, 
  • Pages: 1101-1110
  • First Published: 09 April 2015

Hepatobiliary Malignancies

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Reproducibility of mRECIST in assessing response to transarterial radioembolization therapy in hepatocellular carcinoma

Adeel R. Seyal,  Fernanda D. Gonzalez-Guindalini,  Atilla Arslanoglu,  Carla B. Harmath,  Robert J. Lewandowski,  Riad Salem,  Vahid Yaghmai, 
  • Pages: 1111-1121
  • First Published: 22 May 2015
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Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma

Yinying Lu,  Wanping Xu,  Junfang Ji,  Dechun Feng,  Carole Sourbier,  Youfeng Yang,  Jianhui Qu,  Zhen Zeng,  Chunping Wang,  Xiujuan Chang,  Yan Chen,  Alok Mishra,  Max Xu,  Min-Jung Lee,  Sunmin Lee,  Jane Trepel,  W. Marston Linehan,  Xinwei Wang,  Yongping Yang,  Len Neckers, 
  • Pages: 1122-1131
  • First Published: 08 June 2015
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MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer

Weijie Guo,  Zhaoping Qiu,  Zhichao Wang,  Qifeng Wang,  Ning Tan,  Taoyang Chen,  Zhiao Chen,  Shenglin Huang,  Jianren Gu,  Jinjun Li,  Ming Yao,  Yingjun Zhao,  Xianghuo He, 
  • Pages: 1132-1144
  • First Published: 05 June 2015
Open Access

Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma

Huizhen Nie,  Jun Li,  Xiao-Mei Yang,  Qing-Zhen Cao,  Ming-Xuan Feng,  Feng Xue,  Lin Wei,  Wenxin Qin,  Jianren Gu,  Qiang Xia,  Zhi-Gang Zhang, 
  • Pages: 1145-1159
  • First Published: 16 June 2015
Open Access

Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma

Cheolhee Won,  Byung-Hak Kim,  Eun Hee Yi,  Kyung-Ju Choi,  Eun-Kyung Kim,  Jong-Min Jeong,  Jae-Ho Lee,  Ja-June Jang,  Jung-Hwan Yoon,  Won-Il Jeong,  In-Chul Park,  Tae Woo Kim,  Sun Sik Bae,  Valentina M. Factor,  Stephanie Ma,  Snorri S. Thorgeirsson,  Yun-Han Lee,  Sang-Kyu Ye, 
  • Pages: 1160-1173
  • First Published: 06 July 2015
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Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression

Young-Kyoung Lee,  Byul A. Jee,  So Mee Kwon,  Young-Sil Yoon,  Wei Guang Xu,  Hee-Jung Wang,  Xin Wei Wang,  Snorri S. Thorgeirsson,  Jae-Seon Lee,  Hyun Goo Woo,  Gyesoon Yoon, 
  • Pages: 1174-1189
  • First Published: 14 July 2015
Open Access

World-wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma

Catherine de Martel,  Delphine Maucort-Boulch,  Martyn Plummer,  Silvia Franceschi, 
  • Pages: 1190-1200
  • First Published: 03 July 2015
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Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial-mesenchymal transition

Zhi-Chao Wang,  Qiang Gao,  Jie-Yi Shi,  Wei-Jie Guo,  Liu-Xiao Yang,  Xin-Yang Liu,  Long-Zi Liu,  Li-Jie Ma,  Meng Duan,  Ying-Jun Zhao,  Yong-Na Wu,  Dong-Mei Gao,  Xiao-Ying Wang,  Guo-Ming Shi,  Zhen-Bin Ding,  Ai-Wu Ke,  Qi-Qun Tang,  Ya Cao,  Jian Zhou,  Jia Fan, 
  • Pages: 1201-1214
  • First Published: 22 May 2015

Autoimmune, Cholestatic, and Biliary Disease

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Involvement of a cyclic adenosine monophosphate–dependent signal in the diet-induced canalicular trafficking of adenosine triphosphate–binding cassette transporter g5/g8

Yasuhiro Yamazaki,  Kenta Yasui,  Takahiro Hashizume,  Arisa Suto,  Ayaka Mori,  Yuzuki Murata,  Masahiko Yamaguchi,  Akira Ikari,  Junko Sugatani, 
  • Pages: 1215-1226
  • First Published: 22 May 2015
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Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury

Man Li,  Albert Mennone,  Carol J. Soroka,  Lee R. Hagey,  Xinshou Ouyang,  Edward J. Weinman,  James L. Boyer, 
  • Pages: 1227-1236
  • First Published: 25 June 2015
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Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

Lucía Barbier-Torres,  Naiara Beraza,  Pablo Fernández-Tussy,  Fernando Lopitz-Otsoa,  David Fernández-Ramos,  Imanol Zubiete-Franco,  Marta Varela-Rey,  Teresa C. Delgado,  Virginia Gutiérrez,  Juan Anguita,  Albert Pares,  Jesús M. Banales,  Erica Villa,  Juan Caballería,  Luis Alvarez,  Shelly C. Lu,  Jose M. Mato,  María Luz Martínez-Chantar, 
  • Pages: 1237-1248
  • First Published: 25 June 2015
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The biliary epithelium presents antigens to and activates natural killer T cells

Elisabeth Schrumpf,  Corey Tan,  Tom H. Karlsen,  Jon Sponheim,  Niklas K. Björkström,  Olav Sundnes,  Kristian Alfsnes,  Arthur Kaser,  Douglas M. Jefferson,  Yoshiyuki Ueno,  Tor J. Eide,  Guttorm Haraldsen,  Sebastian Zeissig,  Mark A. Exley,  Richard S. Blumberg,  Espen Melum, 
  • Pages: 1249-1259
  • First Published: 08 April 2015

Liver Failure/Cirrhosis/Portal Hypertension

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Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

Jasmohan S. Bajaj,  Naga S. Betrapally,  Phillip B. Hylemon,  Douglas M. Heuman,  Kalyani Daita,  Melanie B. White,  Ariel Unser,  Leroy R. Thacker,  Arun J. Sanyal,  Dae Joong Kang,  Masoumeh Sikaroodi,  Patrick M Gillevet, 
  • Pages: 1260-1271
  • First Published: 29 March 2015

Liver Injury/Regeneration

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Kupffer cell–monocyte communication is essential for initiating murine liver progenitor cell–mediated liver regeneration

Caryn L. Elsegood,  Chun Wei Chan,  Mariapia A. Degli-Esposti,  Matthew E. Wikstrom,  Alice Domenichini,  Kyren Lazarus,  Nico van Rooijen,  Ruth Ganss,  John K. Olynyk,  George C.T. Yeoh, 
  • Pages: 1272-1284
  • First Published: 14 July 2015

Liver Biology/Pathobiology

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Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis

Carolina Jiménez Calvente,  Alfica Sehgal,  Yury Popov,  Yong Ook Kim,  Victor Zevallos,  Ugur Sahin,  Mustafa Diken,  Detlef Schuppan, 
  • Pages: 1285-1297
  • First Published: 10 June 2015

Special Article

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Direct-acting antiviral drug approvals for treatment of chronic hepatitis C virus infection: Scientific and regulatory approaches to clinical trial designs

Poonam Mishra,  Jeffrey Murray,  Debra Birnkrant, 
  • Pages: 1298-1303
  • First Published: 07 May 2015

New Horizons

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Myeloid cells in hepatocellular carcinoma

Shanshan Wan,  Ning Kuo,  Ilona Kryczek,  Weiping Zou,  Theodore H. Welling, 
  • Pages: 1304-1312
  • First Published: 24 April 2015

Hepatology Elsewhere

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Vascular adhesion protein 1 in nonalcoholic steatohepatitis: A novel biomarker?

Natalie J. Torok M.D., 
  • Pages: 1313-1315
  • First Published: 18 June 2015
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Negative feedback regulation of bile acid metabolism: Impact on liver metabolism and diseases

John Y.L. Chiang PH.D., 
  • Pages: 1315-1317
  • First Published: 29 June 2015

Clinical Observations in Hepatology

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Tenofovir-associated Fanconi syndrome and nephrotic syndrome in a patient with chronic hepatitis B monoinfection

Hyeon Seok Hwang,  Cheol Whee Park,  Myeong Jun Song, 
  • Pages: 1318-1320
  • First Published: 30 January 2015

Correspondence

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TM6SF2 as a genetic risk factor for fibrosis

Ann K. Daly PH.D.,  Christopher P. Day PH.D., F.R.C.P.,  Yang-Lin Liu M.D.,  Quentin M. Anstee PH.D., F.R.C.P., 
  • Page: 1321
  • First Published: 12 December 2014
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Reply

Silvia Sookoian M.D., Ph.D.,  Carlos J. Pirola Ph.D., 
  • Pages: 1321-1322
  • First Published: 12 December 2014
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Could abnormal neutrophil-platelet interactions and complex formation contribute to oxidative stress and organ failure in cirrhosis?

Jonathan P. Sturgeon M.B.B.S.,  Godhev K. Manakkat Vijay M.SC.,  Jennifer Ryan M.B.B.S.,  William Bernal M.D.,  Debbie L Shawcross PH.D., 
  • Pages: 1323-1324
  • First Published: 18 December 2014
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Targeting FGF19 binding to its receptor system: A novel therapeutic approach for hepatocellular carcinoma

Nadia Panera Ph.D.,  Sara Ceccarelli Ph.D.,  Valerio Nobili M.D.,  Anna Alisi Ph.D., 
  • Page: 1324
  • First Published: 11 February 2015
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Reply

Farhan Haq M.Phil,  Sung-Min Ahn M.D. Ph.D, 
  • Pages: 1324-1325
  • First Published: 11 February 2015
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FIB-4 as a prognostic model for patients with hepatitis B–associated hepatocellular carcinoma

Qing Pang M.D., Ph.D.,  Xin Sen Xu M.D.,  Jing Yao Zhang M.D.,  Kai Qu M.D.,  Wei Chen M.D.,  Chang Liu M.D., Ph.D., 
  • Pages: 1325-1326
  • First Published: 02 February 2015
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Putative role of cationic amino acid transporter-3 in murine liver metabolism

Ellen I. Closs Ph.D., 
  • Pages: 1326-1327
  • First Published: 24 February 2015
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Reply

Qilin Gu Ph.D.,  Zongbin Cui Ph.D., 
  • Page: 1327
  • First Published: 24 February 2015
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Transplantation for hepatocellular carcinoma: More haste, less speed?

Tian Yang M.D.,  Wan Yee Lau M.D., F.R.C.S., F.A.C.S., F.R.A.C.S. (Hon.),  Bin Huang M.D.,  Myron Schwartz M.D., F.A.C.S.,  Feng Shen M.D., Ph.D., 
  • Pages: 1327-1328
  • First Published: 29 March 2015
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Reply

Karim J. Halazun M.D.,  Rachel E. Patzer Ph.D., M.P.H.,  Abbas A. Rana M.D.,  Benjamin Samstein M.D.,  Robert S. Brown Jr. M.D., M.P.H.,  Jean C. Emond M.D., 
  • Pages: 1328-1329
  • First Published: 29 March 2015
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Reappearance of serum hepatitis B viral DNA in patients with hepatitis B surface antigen seroclearance

Masato Nakamura M.D.,  Tatsuo Kanda M.D.,  Shingo Nakamoto M.D.,  Yuki Haga M.D.,  Reina Sasaki M.D.,  Xia Jiang M.S.,  Shin Yasui M.D.,  Makoto Arai M.D.,  Osamu Yokosuka M.D., 
  • Page: 1329
  • First Published: 08 January 2015

Corrections

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Correction

  • Page: 1330
  • First Published: 14 July 2015

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Correction

  • Page: 1330
  • First Published: 30 July 2015