• Issue

    Hepatology: Volume 50, Issue 4

    997-1323
    October 2009
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Comments from the Editors

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Hepatitis C drug development at a crossroads†

David R. Nelson M.D., 
  • Pages: 997-999
  • First Published: 28 September 2009

Editorials

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One step at a time: Identification and validation of biomarkers for nonalcoholic steatohepatitis†‡

Jayant A. Talwalkar M.D., M.P.H., 
  • Pages: 1000-1003
  • First Published: 28 September 2009
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Fructose takes a toll†‡

Miriam B. Vos M.D., M.S.P.H.,  Craig J. McClain M.D., 
  • Pages: 1004-1006
  • First Published: 28 September 2009
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Minimal hepatic encephalopathy and driving†‡

Richard M. Dubinsky M.D., M.P.H.,  Anthony C. Stein Ph.D., 
  • Pages: 1007-1008
  • First Published: 28 September 2009
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The liver's dance with death: Two Bcl-2 guardian proteins from the abyss†‡

Sophie C. Cazanave Ph.D.,  Gregory J. Gores M.D., 
  • Pages: 1009-1013
  • First Published: 28 September 2009
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Hepatic drug transporters, old and new: Pharmacogenomics, drug response, and clinical relevance†‡

Marianne K. DeGorter,  Richard B. Kim, 
  • Pages: 1014-1016
  • First Published: 28 September 2009

Viral Hepatitis

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Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen–restricted immune pressure†

Andri Rauch,  Ian James,  Katja Pfafferott,  David Nolan,  Paul Klenerman,  Wendy Cheng,  Lindsay Mollison,  Geoff McCaughan,  Nick Shackel,  Gary P. Jeffrey,  Ross Baker,  Elizabeth Freitas,  Isla Humphreys,  Hansjakob Furrer,  Huldrych F. Günthard,  Bernard Hirschel,  Simon Mallal,  Mina John,  Michaela Lucas,  Eleanor Barnes,  Silvana Gaudieri, 
  • Pages: 1017-1029
  • First Published: 28 September 2009
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Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up†

Kathleen E. Corey,  Erin Kane,  Craig Munroe,  Lydia L. Barlow,  Hui Zheng,  Raymond T. Chung, 
  • Pages: 1030-1037
  • First Published: 28 September 2009
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A seven-gene signature (cirrhosis risk score) predicts liver fibrosis progression in patients with initially mild chronic hepatitis C†

Moira Marcolongo,  Bradford Young,  Francesca Dal Pero,  Giovanna Fattovich,  Laura Peraro,  Maria Guido,  Giada Sebastiani,  Giorgio Palù,  Alfredo Alberti, 
  • Pages: 1038-1044
  • First Published: 28 September 2009
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Impact of high-dose peginterferon alfa-2A on virological response rates in patients with hepatitis C genotype 1: A randomized controlled trial†‡

Stuart K. Roberts,  Martin D. Weltman,  Darrell H. G. Crawford,  Geoffrey W. McCaughan,  William Sievert,  Wendy S. Cheng,  William Rawlinson,  Paul V. Desmond,  Phillipa S. Marks,  Motoko Yoshihara,  Bishoy Rizkalla,  Jean K. DePamphilis,  Gregory J. Dore,  Chariot Study Group , 
  • Pages: 1045-1055
  • First Published: 28 September 2009
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Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus†

Juan Macías,  Juan Berenguer,  Miguel A. Japón,  José A. Girón,  Antonio Rivero,  Luis F. López-Cortés,  Ana Moreno,  Mercedes González-Serrano,  José A. Iribarren,  Enrique Ortega,  Pilar Miralles,  José A. Mira,  Juan A. Pineda, 
  • Pages: 1056-1063
  • First Published: 28 September 2009
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Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone†

Ju Hyun Shim,  Dong Jin Suh,  Kang Mo Kim,  Young-Suk Lim,  Han Chu Lee,  Young-Hwa Chung,  Yung Sang Lee, 
  • Pages: 1064-1071
  • First Published: 28 September 2009

Steatohepatitis/Metabolic Liver Disease

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Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study†

Ariel E. Feldstein,  Anna Wieckowska,  A. Rocio Lopez,  Yao-Chang Liu,  Nizar N. Zein,  Arthur J. McCullough, 
  • Pages: 1072-1078
  • First Published: 28 September 2009
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Abnormal hepatic energy homeostasis in type 2 diabetes†

Julia Szendroedi,  Marek Chmelik,  Albrecht Ingo Schmid,  Peter Nowotny,  Attila Brehm,  Martin Krssak,  Ewald Moser,  Michael Roden, 
  • Pages: 1079-1086
  • First Published: 28 September 2009
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Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis†

Amalia Gastaldelli,  Stephen A. Harrison,  Renata Belfort-Aguilar,  Lou Jean Hardies,  Bogdan Balas,  Steven Schenker,  Kenneth Cusi, 
  • Pages: 1087-1093
  • First Published: 28 September 2009
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Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice†

Astrid Spruss,  Giridhar Kanuri,  Sabine Wagnerberger,  Synia Haub,  Stephan C. Bischoff,  Ina Bergheim, 
  • Pages: 1094-1104
  • First Published: 28 September 2009
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Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss†

Nathan A. Johnson,  Toos Sachinwalla,  David W. Walton,  Kate Smith,  Ashley Armstrong,  Martin W. Thompson,  Jacob George, 
  • Pages: 1105-1112
  • First Published: 28 September 2009
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Nonalcoholic steatohepatitis in children: A multicenter clinicopathological study†

Christine Carter-Kent,  Lisa M. Yerian,  Elizabeth M. Brunt,  Paul Angulo,  Rohit Kohli,  Simon C. Ling,  Stavra A. Xanthakos,  Peter F. Whitington,  Phunchai Charatcharoenwitthaya,  Jason Yap,  Rocio Lopez,  Arthur J. McCullough,  Ariel E. Feldstein, 
  • Pages: 1113-1120
  • First Published: 28 September 2009

Hepatobiliary Malignancies

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Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth†

Uta Rabenhorst,  Rasa Beinoraviciute-Kellner,  Marie-Luise Brezniceanu,  Stefan Joos,  Frauke Devens,  Peter Lichter,  Ralf J. Rieker,  Jörg Trojan,  Hye-Jung Chung,  David L. Levens,  Martin Zörnig, 
  • Pages: 1121-1129
  • First Published: 28 September 2009
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Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells†‡

Mona Malz,  Achim Weber,  Stephan Singer,  Vera Riehmer,  Michaela Bissinger,  Marc-Oliver Riener,  Thomas Longerich,  Christopher Soll,  Arndt Vogel,  Peter Angel,  Peter Schirmacher,  Kai Breuhahn, 
  • Pages: 1130-1139
  • First Published: 28 September 2009
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Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation†

Antonio Mazzocca,  Emilia Fransvea,  Gabriela Lavezzari,  Salvatore Antonaci,  Gianluigi Giannelli, 
  • Pages: 1140-1151
  • First Published: 28 September 2009
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Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid–defined diet in C57BL/6 mice†

Bo Wang,  Sarmila Majumder,  Gerard Nuovo,  Huban Kutay,  Stefano Volinia,  Tushar Patel,  Thomas D. Schmittgen,  Carlo Croce,  Kalpana Ghoshal,  Samson T. Jacob, 
  • Pages: 1152-1161
  • First Published: 28 September 2009

Autoimmune, Cholestatic and Biliary Disease

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Incidence, risk factors, and survival of hepatocellular carcinoma in primary biliary cirrhosis: Comparative analysis from two centers†

Anna Cavazza,  Llorenç Caballería,  Annarosa Floreani,  Fabio Farinati,  Miquel Bruguera,  Diego Caroli,  Albert Parés, 
  • Pages: 1162-1168
  • First Published: 28 September 2009
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Are transient environmental agents involved in the cause of primary biliary cirrhosis? Evidence from space–time clustering analysis†

Richard J. Q. McNally,  Samantha Ducker,  Oliver F. W. James, 
  • Pages: 1169-1174
  • First Published: 28 September 2009

Liver Failure/Cirrhosis/Portal Hypertension

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Minimal hepatic encephalopathy is associated with motor vehicle crashes: The reality beyond the driving test†

Jasmohan S. Bajaj,  Kia Saeian,  Christine M. Schubert,  Muhammad Hafeezullah,  Jose Franco,  Rajiv R. Varma,  Douglas P. Gibson,  Raymond G. Hoffmann,  R. Todd Stravitz,  Douglas M. Heuman,  Richard K. Sterling,  Mitchell Shiffman,  Allyne Topaz,  Sherry Boyett,  Debulon Bell,  Arun J. Sanyal, 
  • Pages: 1175-1183
  • First Published: 28 September 2009
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A novel nonsynonymous variant of matrix metalloproteinase-7 confers risk of liver cirrhosis†

Tzu-Min Hung,  Shin C. Chang,  Wei-Hsuan Yu,  Yu-Wen Wang,  Cheng Huang,  Shao-Chun Lu,  Po-Huang Lee,  Ming-Fu Chang, 
  • Pages: 1184-1193
  • First Published: 28 September 2009

Liver Injury/Regeneration

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Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice†

Kang Cheng,  Daniel Benten,  Kuldeep Bhargava,  Mari Inada,  Brigid Joseph,  Christopher Palestro,  Sanjeev Gupta, 
  • Pages: 1194-1203
  • First Published: 28 September 2009

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Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury†

Yingli Shang,  Yong Liu,  Lei Du,  Youliang Wang,  Xuan Cheng,  Weiming Xiao,  Xiaohui Wang,  Haijing Jin,  Xiao Yang,  Shusen Liu,  Quan Chen, 
  • Pages: 1204-1216
  • First Published: 28 September 2009
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Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver†

Hayato Hikita,  Tetsuo Takehara,  Satoshi Shimizu,  Takahiro Kodama,  Wei Li,  Takuya Miyagi,  Atsushi Hosui,  Hisashi Ishida,  Kazuyoshi Ohkawa,  Tatsuya Kanto,  Naoki Hiramatsu,  Xiao-Ming Yin,  Lothar Hennighausen,  Tomohide Tatsumi,  Norio Hayashi, 
  • Pages: 1217-1226
  • First Published: 28 September 2009

Liver Biology/Pathobiology

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver†

Anne T. Nies,  Hermann Koepsell,  Stefan Winter,  Oliver Burk,  Kathrin Klein,  Reinhold Kerb,  Ulrich M. Zanger,  Dietrich Keppler,  Matthias Schwab,  Elke Schaeffeler, 
  • Pages: 1227-1240
  • First Published: 28 September 2009
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Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4α and peroxisome proliferator-activated receptor-α†

Xinqin Kang,  Wei Zhong,  Jie Liu,  Zhenyuan Song,  Craig J. McClain,  Y. James Kang,  Zhanxiang Zhou, 
  • Pages: 1241-1250
  • First Published: 28 September 2009
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S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis†

Julia Németh,  Ilan Stein,  Daniel Haag,  Astrid Riehl,  Thomas Longerich,  Elad Horwitz,  Kai Breuhahn,  Christoffer Gebhardt,  Peter Schirmacher,  Meinhard Hahn,  Yinon Ben-Neriah,  Eli Pikarsky,  Peter Angel,  Jochen Hess, 
  • Pages: 1251-1262
  • First Published: 28 September 2009
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Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice†

Harmen Wiersma,  Alberto Gatti,  Niels Nijstad,  Ronald P. J. Oude Elferink,  Folkert Kuipers,  Uwe J. F. Tietge, 
  • Pages: 1263-1272
  • First Published: 28 September 2009
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Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6†‡

Banchob Sripa,  Eimorn Mairiang,  Bandit Thinkhamrop,  Thewarach Laha,  Sasithorn Kaewkes,  Paiboon Sithithaworn,  Smarn Tessana,  Alex Loukas,  Paul J. Brindley,  Jeffrey M. Bethony, 
  • Pages: 1273-1281
  • First Published: 28 September 2009

Reviews

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Advances in pediatric nonalcoholic fatty liver disease†

Rohit Loomba,  Claude B. Sirlin,  Jeffrey B. Schwimmer,  Joel E. Lavine, 
  • Pages: 1282-1293
  • First Published: 28 September 2009
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Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies†

Yury Popov,  Detlef Schuppan, 
  • Pages: 1294-1306
  • First Published: 28 September 2009

Hepatology Elsewhere

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Hepatitis C nonresponders: Re-treat or retreat?†

Michael Leise,  W. Ray Kim, 
  • Pages: 1307-1309
  • First Published: 29 September 2009
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Liver “Tick Tock”†

Nicholas A. Shackel, 
  • Pages: 1310-1311
  • First Published: 29 September 2009

Image of the Month

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Copper-metallothionein autofluorescence†

Alberto Quaglia,  Ahlam Mustafa,  Ragai R. Mitry,  Bernard Portmann, 
  • Pages: 1312-1313
  • First Published: 28 September 2009

Correspondence

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Does hepatitis B surface antigen kinetics, including both decline and reaching a threshold, improve prediction of response?†

Johannes Wiegand,  Keyur Patel,  Hans L. Tillmann, 
  • Page: 1314
  • First Published: 28 September 2009
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Reply:†

Maurizia R. Brunetto, 
  • Page: 1314
  • First Published: 28 September 2009
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Polymorphism in the endoplasmic reticulum mannosidase I (MAN1B1) gene is not associated with liver disease in individuals homozygous for the Z variant of the alpha1-antitrypsin protease inhibitor (PiZZ individuals)†

Sally Chappell,  Tamar Guetta-Baranés,  Nedim Hadzic,  Robert Stockley,  Noor Kalsheker, 
  • Page: 1315
  • First Published: 28 September 2009
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Reply:†

Shujuan Pan,  Richard N. Sifers, 
  • Pages: 1315-1316
  • First Published: 28 September 2009
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Comments on minimizing misdiagnosis of hepatocellular carcinoma from magnetic resonance imaging†

Yun Ku Cho M.D., 
  • Page: 1316
  • First Published: 28 September 2009
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Reply:†

Jordi Rimola M.D.,  Alejandro Forner M.D.,  Carmen Ayuso Ph.D.,  Jordi Bruix Ph.D.,  BCLC Group , 
  • Pages: 1316-1317
  • First Published: 28 September 2009
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Coffee drinking and hepatocellular carcinoma: An update†

Francesca Bravi,  Cristina Bosetti,  Alessandra Tavani,  Carlo La Vecchia, 
  • Pages: 1317-1318
  • First Published: 28 September 2009
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Endotoxemia in alcoholic liver disease†

Tetsuji Fujita M.D., 
  • Page: 1319
  • First Published: 28 September 2009
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Reply:†

Radhakrishna K. Rao, 
  • Page: 1319
  • First Published: 29 September 2009
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Role of cholesterol determination in ascitic fluid analysis†

Alexander L. Gerbes,  Dieter Jüngst, 
  • Page: 1320
  • First Published: 28 September 2009
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The management of cirrhotic ascites†

Gin-ho Lo M.D., 
  • Page: 1320
  • First Published: 28 September 2009
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Management of adult patients with ascites due to cirrhosis: An update†

Bruce A. Runyon M.D., 
  • Page: 1321
  • First Published: 28 September 2009
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Molecular mechanism of endotoxin tolerance†

Tetsuji Fujita M.D., 
  • Page: 1322
  • First Published: 28 September 2009
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MicroRNA-122 might be a double-edged sword in hepatocellular carcinoma†

Rui Zhang,  Lei Wang,  Gui-Rong Yu,  Xiang Zhang,  Li-Bo Yao,  An-Gang Yang, 
  • Pages: 1322-1323
  • First Published: 28 September 2009