This schematic illustrates the proposed mechanism whereby MMMA, a key component of bone cement, activates MRGPRX2 receptors on mast cells or basophils. This activation triggers the release of histamine, leading to vasodilation and hypotension—hallmarks of bone cement implantation syndrome.

We used XAI to identify key sepsis-related genes TIMP1, GSTO1 and MYL6, which are highly expressed in various cell types and clinical features. Molecular docking results show that navitoclax, curcumin and rotenone may have a strong binding affinity with these genes.

AZ505, a highly selective inhibitor of SMYD2, may exhibit an antifibrotic effect in peritoneal fibrosis.

LIN interacted with COX2 to inhibit inflammation, apoptosis and oxidative stress in LPS-induced AKI.