The cover image is based on the Research Letter Unique basophil microRNA signature in chronic spontaneous urtricaria patients who respond to omalizumab by William Reed Henderson et al., https://doi.org/10.1111/cea.14014.

Heterogenic diseases as asthma, atopic dermatitis and chronic rhinosinusitis with nasal polyposis can be divided into multiple phenotypes. Such clinical presentations share common pathophysiological paths among with type 2 immunity play an important role. Better understanding of the mechanisms underlying type 2 responses allowed the successful development of specific therapeutic strategies. Indeed, biotherapies are now available to target key actors like the immunoglobulin E, the interleukin (IL) 5, the IL-4 and IL-13 pathway and more recently, the thymic stromal lymphopoietin. Even though those innovations improve the healthcare of type-2 mediated diseases, unmet needs remain to be resolved. Graphic abstract created with BioRender.com

Little or no concordance among raw data, substantial agreement comparing dichotomized data (94,3% concordant results). Heterogeneity of results comparing plant and animal panallergens recognition of the two methods Almost perfect agreement in 27% components, and good in further 31% between the 102 molecules present in both systems Binding with carbohydrate determinants abolished in 60% of cases with ALEX system Better performance of the ISAC® test on cross-reactive molecules, wider patients identification with ALEX2® system.

Exploratory study characterizing the impact of daily cat exposure in cat-allergic subjects living with/without cats (WC/WoC). Cat dander- and Fel d 1-specific IgG4 concentrations were higher in WC versus WoC subjects (p < .05); lower basophil sensitivity to cat dander extract/Fel d 1 in WC versus WoC subjects (p < .05) correlated with higher IgG4 concentrations (r = 0.63; p = .009). Immunological differences not reflected in clinical tolerance with cat exposure. Fel d 1, major cat allergen; Ig, immunoglobulin; WC, with cat; WoC, without cat.