Developments in the field of allergy in 2020 through the eyes of Clinical and Experimental Allergy
Corresponding Author
Robert J. Boyle
National Heart and Lung Institute, Imperial College London, London, UK
Correspondence
Robert Boyle, National Heart and Lung Institute, Wright Fleming Institute, Imperial College London, London W2 1PG, United Kingdom.
Email: [email protected]
Search for more papers by this authorMohamed H. Shamji
National Heart and Lung Institute, Imperial College London, London, UK
NIHR Imperial Biomedical Research Centre, London, UK
Search for more papers by this authorCorresponding Author
Robert J. Boyle
National Heart and Lung Institute, Imperial College London, London, UK
Correspondence
Robert Boyle, National Heart and Lung Institute, Wright Fleming Institute, Imperial College London, London W2 1PG, United Kingdom.
Email: [email protected]
Search for more papers by this authorMohamed H. Shamji
National Heart and Lung Institute, Imperial College London, London, UK
NIHR Imperial Biomedical Research Centre, London, UK
Search for more papers by this authorAbstract
While 2020 will be remembered for the global coronavirus pandemic, there were also important advances in the field of allergy. In this review article, we summarize key findings reported in Clinical and Experimental Allergy during 2020. We hope this provides readers with an accessible snapshot of the work published in our journal during this time.
REFERENCES
- 1Yao Y, Wang H, Liu Z. Expression of ACE2 in airways: Implication for COVID-19 risk and disease management in patients with chronic inflammatory respiratory diseases. Clin Exp Allergy. 2020; 50(12): 1313-1324.
- 2Chalubinski M, Gajewski A, Kowalski ML. The relationship between human coronaviruses, asthma and allergy-An unresolved dilemma. Clin Exp Allergy. 2020; 50(10): 1122-1126.
- 3Wang Y, Ao G, Qi X, Xie B. The association between COVID-19 and asthma: a systematic review and meta-analysis. Clin Exp Allergy. 2020; 50(11): 1274-1277.
- 4Roberts G. Inducible laryngeal obstruction, COVID-19 and asthma. Clin Exp Allergy. 2020; 50(11): 1210-1211.
- 5Haines J, Esposito K, Slinger C, et al. UK consensus statement on the diagnosis of inducible laryngeal obstruction in light of the COVID-19 pandemic. Clin Exp Allergy. 2020; 50(12): 1287-1293.
- 6Haines J, Chua SHK, Smith J, Slinger C, Simpson AJ, Fowler SJ. Triggers of breathlessness in inducible laryngeal obstruction and asthma. Clin Exp Allergy. 2020; 50(11): 1230-1237.
- 7Shiroshita A, Jin Z, Tanaka Y, Kataoka Y. Diagnostic accuracy and safety of inhalation challenge tests for bird fancier's lung-Systematic review and meta-analysis. Clin Exp Allergy. 2020; 50(9): 1007-1016.
- 8Walter S, Ho J, Alvarado R, et al. Effect of monoclonal antibody drug therapy on mucosal biomarkers in airway disease: a systematic review. Clin Exp Allergy. 2020; 50(11): 1212-1222.
- 9Jendoubi F, Gaudenzio N, Gallini A, Negretto M, Paul C, Bulai LC. Omalizumab in the treatment of adult patients with mastocytosis: a systematic review. Clin Exp Allergy. 2020; 50(6): 654-661.
- 10Bourdin A, Husereau D, Molinari N, et al. Matching-adjusted comparison of oral corticosteroid reduction in asthma: systematic review of biologics. Clin Exp Allergy. 2020; 50(4): 442-452.
- 11Muir AB, Whelan KA, Dougherty MK, et al. The potential for malignancy from atopic disorders and allergic inflammation: a systematic review and meta-analysis. Clin Exp Allergy. 2020; 50(2): 147-159.
- 12Polloni L, Muraro A. Anxiety and food allergy: a review of the last two decades. Clin Exp Allergy. 2020; 50(4): 420-441.
- 13Strozyk A, Horvath A, Meyer R, Szajewska H. Efficacy and safety of hydrolyzed formulas for cow's milk allergy management: a systematic review of randomized controlled trials. Clin Exp Allergy. 2020; 50(7): 766-779.
- 14Gohy S, Hulin C, Ladjemi MZ, Hox V, Pilette C. Key role of the epithelium in chronic upper airways diseases. Clin Exp Allergy. 2020; 50(2): 135-146.
- 15Ryu G, Dhong HJ, Park M, et al. Age-associated changes in chronic rhinosinusitis endotypes. Clin Exp Allergy. 2020; 50(5): 585-596.
- 16Sundbom F, Malinovschi A, Lindberg E, Almqvist C, Janson C. Insomnia symptoms and asthma control-Interrelations and importance of comorbidities. Clin Exp Allergy. 2020; 50(2): 170-177.
- 17Almqvist C, Ekberg S, Rhein S, Fang F, Fall T, Lundholm C. Season of birth, childhood asthma and allergy in a nationwide cohort-Mediation through lower respiratory infections. Clin Exp Allergy. 2020; 50(2): 222-230.
- 18Nwaru BI, Ohlsson C, Bygdell M, Martikainen J, Kindblom JM. Pubertal BMI change and adult-onset asthma in men: population-based cohort study in Sweden. Clin Exp Allergy. 2020; 50(1): 51-60.
- 19Turkalj M, Drkulec V, Haider S, et al. Association of bacterial load in drinking water and allergic diseases in childhood. Clin Exp Allergy. 2020; 50(6): 733-740.
- 20Deliu M, Fontanella S, Haider S, et al. Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes. Clin Exp Allergy. 2020; 50(3): 315-324.
- 21Fasola S, Montalbano L, Ferrante G, et al. RAPP-children: a new tool for assessing quality of life in patients with asthma and rhinitis. Clin Exp Allergy. 2020; 50(6): 662-671.
- 22Pechsrichuang P, Jacquet A. Molecular approaches to allergen-specific immunotherapy: are we so far from clinical implementation? Clin Exp Allergy. 2020; 50(5): 543-557.
- 23Sola Martinez FJ, Barranco Jimenez RM, Martin Garcia C, et al. Intradermal Phleum pratense allergoid immunotherapy. Double-blind, randomized, placebo-controlled trial. Clin Exp Allergy. 2020; 50(12): 1352-1361.
- 24Zieglmayer P, Schmutz R, Lemell P, et al. Fast effectiveness of a solubilized low-dose budesonide nasal spray in allergic rhinitis. Clin Exp Allergy. 2020; 50(9): 1065-1077.
- 25Pelaia C, Crimi C, Pelaia G, et al. Real-life evaluation of mepolizumab efficacy in patients with severe eosinophilic asthma, according to atopic trait and allergic phenotype. Clin Exp Allergy. 2020; 50(7): 780-788.
- 26Roberts G. Understanding the response to asthma biological therapy. Clin Exp Allergy. 2020; 50(9): 992-993.
- 27Upham JW, Jurak LM. How do biologicals and other novel therapies effect clinically used biomarkers in severe asthma? Clin Exp Allergy. 2020; 50(9): 994-1006.
- 28Dupin C, Belhadi D, Guilleminault L, et al. Effectiveness and safety of dupilumab for the treatment of severe asthma in a real-life French multi-centre adult cohort. Clin Exp Allergy. 2020; 50(7): 789-798.
- 29Gu C, Upchurch K, Mamaril-Davis J, et al. Obesity influences the outcomes of anti-IgE (omalizumab) therapy of asthma. Clin Exp Allergy. 2020; 50(10): 1196-1199.
- 30Lommatzsch M, Marchewski H, Schwefel G, Stoll P, Virchow JC, Bratke K. Benralizumab strongly reduces blood basophils in severe eosinophilic asthma. Clin Exp Allergy. 2020; 50(11): 1267-1269.
- 31Mai HL, Nguyen TVH, Bouchaud G, et al. Targeting the interleukin-7 receptor alpha by an anti-CD127 monoclonal antibody improves allergic airway inflammation in mice. Clin Exp Allergy. 2020; 50(7): 824-834.
- 32Patel G, Pan J, Ye L, et al. Blockade of IL-4Ralpha inhibits group 2 innate lymphoid cell responses in asthma patients. Clin Exp Allergy. 2020; 50(2): 267-270.
- 33Austin CD, Gonzalez Edick M, Ferrando RE, et al. A randomized, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER). Clin Exp Allergy. 2020; 50(12): 1342-1351.
- 34Harb H, Chatila TA. Mechanisms of Dupilumab. Clin Exp Allergy. 2020; 50(1): 5-14.
- 35Kerr SC, Gonzalez JR, Schanin J, et al. An anti-siglec-8 antibody depletes sputum eosinophils from asthmatic subjects and inhibits lung mast cells. Clin Exp Allergy. 2020; 50(8): 904-914.
- 36Schleich F, Graff S, Nekoee H, et al. Real-word experience with mepolizumab: does it deliver what it has promised? Clin Exp Allergy. 2020; 50(6): 687-695.
- 37Wardlaw A, Howarth PH, Israel E, et al. Fungal sensitization and its relationship to mepolizumab response in patients with severe eosinophilic asthma. Clin Exp Allergy. 2020; 50(7): 869-872.
- 38Upchurch K, Wiest M, Cardenas J, et al. Whole blood transcriptional variations between responders and non-responders in asthma patients receiving omalizumab. Clin Exp Allergy. 2020; 50(9): 1017-1034.
- 39Davies ER, Perotin JM, Kelly JFC, et al. Involvement of the epidermal growth factor receptor in IL-13-mediated corticosteroid-resistant airway inflammation. Clin Exp Allergy. 2020; 50(6): 672-686.
- 40Du K, Zheng M, Zhao Y, et al. Impaired small airway function in non-asthmatic chronic rhinosinusitis with nasal polyps. Clin Exp Allergy. 2020; 50(12): 1362-1371.
- 41Ekstedt S, Larsson O, Kumlien Georen S, Cardell LO. CD16(high) CD62L(dim) neutrophils induce nerve-mediated airway hyperreactivity. Clin Exp Allergy. 2020; 50(6): 756-759.
- 42Esnault S, Leet JP, Johansson MW, et al. Eosinophil cytolysis on Immunoglobulin G is associated with microtubule formation and suppression of rho-associated protein kinase signalling. Clin Exp Allergy. 2020; 50(2): 198-212.
- 43Fricker M, Qin L, Niessen N, et al. Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma. Clin Exp Allergy. 2020; 50(6): 696-707.
- 44Gehring U, Wijga AH, Koppelman GH, Vonk JM, Smit HA, Brunekreef B. House dust endotoxin, asthma and allergic sensitization through childhood into adolescence. Clin Exp Allergy. 2020; 50(9): 1055-1064.
- 45Hadjigol S, Netto KG, Maltby S, et al. Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation. Clin Exp Allergy. 2020; 50(1): 82-94.
- 46Jiang J, Faiz A, Berg M, et al. Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma. Clin Exp Allergy. 2020; 50(12): 1428-1431.
- 47Kozlik P, Zuk J, Bartyzel S, et al. The relationship of airway structural changes to blood and bronchoalveolar lavage biomarkers, and lung function abnormalities in asthma. Clin Exp Allergy. 2020; 50(1): 15-28.
- 48Lauzon-Joset JF, Mincham KT, Abad AP, et al. Oestrogen amplifies pre-existing atopy-associated Th2 bias in an experimental asthma model. Clin Exp Allergy. 2020; 50(3): 391-400.
- 49Lejeune S, Mordacq C, Drumez E, et al. Relationship between immune parameters during a severe exacerbation in allergic asthmatic children and asthma outcomes in the following year. Clin Exp Allergy. 2020; 50(3): 406-411.
- 50Liang Y, Feng Y, Wu W, et al. microRNA-218-5p plays a protective role in eosinophilic airway inflammation via targeting delta-catenin, a novel catenin in asthma. Clin Exp Allergy. 2020; 50(1): 29-40.
- 51Lundholm C, Gunnerbeck A, D'Onofrio BM, Larsson H, Pershagen G, Almqvist C. Smoking and snuff use in pregnancy and the risk of asthma and wheeze in pre-schoolchildren-A population-based register study. Clin Exp Allergy. 2020; 50(5): 597-608.
- 52Malmstrom K, Lohi J, Malmberg LP, et al. Airway hyperresponsiveness, remodeling and inflammation in infants with wheeze. Clin Exp Allergy. 2020; 50(5): 558-566.
- 53Moorehead A, Hanna R, Heroux D, et al. A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression. Clin Exp Allergy. 2020; 50(4): 471-478.
- 54Pivniouk V, Gimenes Junior JA, Honeker LK, Vercelli D. The role of innate immunity in asthma development and protection: lessons from the environment. Clin Exp Allergy. 2020; 50(3): 282-290.
- 55Rick EM, Woolnough KF, Seear PJ, et al. The airway fungal microbiome in asthma. Clin Exp Allergy. 2020; 50(12): 1325-1341.
- 56Sangaphunchai P, Todd I, Fairclough LC. Extracellular vesicles and asthma: a review of the literature. Clin Exp Allergy. 2020; 50(3): 291-307.
- 57Shigemasa R, Masuko H, Hyodo K, et al. Genetic impact of CDHR3 on the adult-onset of asthma and COPD. Clin Exp Allergy. 2020; 50(11): 1223-1229.
- 58Sodemann EB, Dahling S, Klopfleisch R, et al. Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation. Clin Exp Allergy. 2020; 50(4): 520-531.
- 59Wu M, Yang Y, Yuan L, et al. DNA methylation down-regulates integrin beta4 expression in asthmatic airway epithelial cells. Clin Exp Allergy. 2020; 50(10): 1127-1139.
- 60Gherasim A, Jacob A, Schoettle F, Domis N, de Blay F. Efficacy of air cleaners in asthmatics allergic to cat in ALYATEC((R)) environmental exposure chamber. Clin Exp Allergy. 2020; 50(2): 160-169.
- 61Jabbal S, Kuo CR, Lipworth B. Randomized controlled trial of triple versus dual inhaler therapy on small airways in smoking asthmatics. Clin Exp Allergy. 2020; 50(10): 1140-1147.
- 62Ortega H, Fitzgerald M, Raghupathi K, et al. A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild-to-moderate asthma. Clin Exp Allergy. 2020; 50(2): 189-197.
- 63Ose R, Tu J, Schink A, et al. Cinnamon extract inhibits allergen-specific immune responses in human and murine allergy models. Clin Exp Allergy. 2020; 50(1): 41-50.
- 64Park KH, Oh EY, Han H, et al. Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model. Clin Exp Allergy. 2020; 50(9): 1084-1092.
- 65Riffo-Vasquez Y, Kanabar V, Keir SD, et al. Modulation of allergic inflammation in the lung by a peptide derived from Mycobacteria tuberculosis chaperonin 60.1. Clin Exp Allergy. 2020; 50(4): 508-519.
- 66Sio YY, Matta SA, Ng YT, Chew FT. Epistasis between phenylethanolamine N-methyltransferase and beta2-adrenergic receptor influences extracellular epinephrine level and associates with the susceptibility to allergic asthma. Clin Exp Allergy. 2020; 50(3): 352-363.
- 67Sokulsky LA, Goggins B, Sherwin S, et al. GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1alpha-induced eosinophilic airway inflammation. Clin Exp Allergy. 2020; 50(5): 609-624.
- 68Miller M, Rosenthal P, Weng N, et al. Chromosome 17q21 SNP rs8076131 risk allele associates with airway smooth muscle hypertrophy in fatal asthma. Clin Exp Allergy. 2020; 50(11): 1270-1273.
- 69Turner PJ, Regent L, Jones C, Fox AT. Keeping food-allergic children safe in our schools-Time for urgent action. Clin Exp Allergy. 2020; 50(2): 133-134.
- 70DunnGalvin A, Gallop K, Acaster S, et al. APPEAL-2: A pan-European qualitative study to explore the burden of peanut-allergic children, teenagers and their caregivers. Clin Exp Allergy. 2020; 50(11): 1238-1248.
- 71Acaster S, Gallop K, de Vries J, Ryan R, Vereda A, Knibb RC. Peanut allergy impact on productivity and quality of life (PAPRIQUA): Caregiver-reported psychosocial impact of peanut allergy on children. Clin Exp Allergy. 2020; 50(11): 1249-1257.
- 72Rutkowski K, Wagner A, Rutkowski R, Sowa P, Pancewicz S, Moniuszko-Malinowska A. Alpha-gal syndrome: An emerging cause of food and drug allergy. Clin Exp Allergy. 2020; 50(8): 894-903.
- 73Rahman M, Baten A, Mauleon R, King GJ, Liu L, Barkla BJ. Identification, characterization and epitope mapping of proteins encoded by putative allergenic napin genes from Brassica rapa. Clin Exp Allergy. 2020; 50(7): 848-868.
- 74Popp J, Trendelenburg V, Niggemann B, et al. Pea (Pisum sativum) allergy in children: Pis s 1 is an immunodominant major pea allergen and presents IgE binding sites with potential diagnostic value. Clin Exp Allergy. 2020; 50(5): 625-635.
- 75Ehlers AM, Otten HG, Wierzba E, et al. Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen's egg allergy in adults. Clin Exp Allergy. 2020; 50(12): 1415-1423.
- 76Bernard H, Turner PJ, Ah-Leung S, Ruiz-Garcia M, Clare Mills EN, Adel-Patient K. Circulating Ara h 6 as a marker of peanut protein absorption intolerant and allergic humans following ingestion of peanut-containing foods. Clin Exp Allergy. 2020; 50(9): 1093-1102.
- 77Aalberse RC, Mueller GA, Derksen NIL, et al. Identification of the amino-terminal fragment of Ara h 1 as a major target of the IgE-binding activity in the basic peanut protein fraction. Clin Exp Allergy. 2020; 50(3): 401-405.
- 78Pedrosa M, Guerrero-Sanchez VM, Canales-Bueno N, et al. Quercus ilex pollen allergen, Que i 1, responsible for pollen food allergy syndrome caused by fruits in Spanish allergic patients. Clin Exp Allergy. 2020; 50(7): 815-823.
- 79Xu LZ, Xie RD, Xie H, et al. Chimeric specific antigen epitope-carrying dendritic cells induce interleukin-17(+) regulatory T cells to suppress food allergy. Clin Exp Allergy. 2020; 50(2): 231-243.
- 80Pouessel G, Jean-Bart C, Deschildre A, et al. Food-induced anaphylaxis in infancy compared to preschool age: a retrospective analysis. Clin Exp Allergy. 2020; 50(1): 74-81.
- 81Pouessel G, Antoine M, Lejeune S, et al. The time course of anaphylaxis manifestations in children is diverse and unpredictable. Clin Exp Allergy. 2020; 50(1): 117-120.
- 82Jensen ET, Langefeld CD, Zimmerman KD, Howard TD, Dellon ES. Epigenetic methylation in eosinophilic esophagitis: molecular ageing and novel biomarkers for treatment response. Clin Exp Allergy. 2020; 50(12): 1372-1380.
- 83Kelleher MM, Jay N, Perkin MR, et al. An algorithm for diagnosing IgE-mediated food allergy in study participants who do not undergo food challenge. Clin Exp Allergy. 2020; 50(3): 334-342.
- 84Versluis A, Knulst AC, van Erp FC, et al. Reintroduction failure after negative food challenges in adults is common and mainly due to atypical symptoms. Clin Exp Allergy. 2020; 50(4): 479-486.
- 85Alviani C, Burrell S, Macleod A, et al. Anaphylaxis Refractory to intramuscular adrenaline during in-hospital food challenges: a case series and proposed management. Clin Exp Allergy. 2020; 50(12): 1400-1405.
- 86Plundrich NJ, Smith AR, Borst LB, et al. Oesophageal eosinophilia accompanies food allergy to hen egg white protein in young pigs. Clin Exp Allergy. 2020; 50(1): 95-104.
- 87Philpott H, Lee SZ, Arrington A, McGee SJ, Dellon ES. Impact of food challenge on local oesophageal immunophenotype in eosinophilic oesophagitis. Clin Exp Allergy. 2020; 50(4): 463-470.
- 88Orsini Delgado ML, Rizzo GP, Fossati CA, et al. Sublingual Omp16-driven redirection of the allergic intestinal response in a pre-clinical model of food allergy. Clin Exp Allergy. 2020; 50(8): 954-963.
- 89Graversen KB, Ballegaard AR, Kraemer LH, et al. Cow's milk allergy prevention and treatment by heat-treated whey-A study in Brown Norway rats. Clin Exp Allergy. 2020; 50(6): 708-721.
- 90Silva F, Oliveira EE, Ambrosio MGE, et al. High-fat diet-induced obesity worsens TH2 immune response and immunopathologic characteristics in murine model of eosinophilic oesophagitis. Clin Exp Allergy. 2020; 50(2): 244-255.
- 91Protudjer JLP, Golding M, Bouwman T, Ben-Shoshan M, Abrams EM. GRAded oral challenge for Drug allergy Evaluation-Delabelling described through families’ voices. Clin Exp Allergy. 2020; 50(9): 1078-1083.
- 92Reichel A, Roding K, Stoevesandt J, Trautmann A. De-labelling antibiotic allergy through five key questions. Clin Exp Allergy. 2020; 50(4): 532-535.
- 93Gaffar J, Gabrielli S, Lavine E, et al. Diagnosis of Ibuprofen allergy through oral challenge. Clin Exp Allergy. 2020; 50(5): 636-639.
- 94Liccioli G, Mori F, Parronchi P, et al. Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9-year experience in a tertiary care paediatric hospital setting. Clin Exp Allergy. 2020; 50(1): 61-73.
- 95Trautmann A, Brockow K, Stoevesandt J. Metamizole-induced reactions as a paradigm of drug hypersensitivity: Non-allergic reactions, anaphylaxis, and delayed-type allergy. Clin Exp Allergy. 2020; 50(9): 1103-1106.
- 96Van Gasse AL, Ebo DG, Mertens CM, et al. CD154 (CD40L): A novel aid to document nonimmediate hypersensitivity to amoxicillin or amoxicillin-clavulanic acid. Clin Exp Allergy. 2020; 50(5): 640-642.
- 97Vega F, Mugica MV, Bazire R, et al. Adverse reactions to iodinated contrast media: Safety of a study protocol that includes fast full-dose parenteral challenge tests searching for an alternative contrast media. Clin Exp Allergy. 2020; 50(2): 271-274.
- 98Bahal S, Zinser E, Morrison C, Msonthi A, Pillai P, Ali FR. Identification of factors affecting the outcome of General Anaesthetic Allergy Testing. Clin Exp Allergy. 2020; 50(8): 977-980.
- 99Vega F, Mugica MV, Argiz L, et al. Protocol to prevent contrast-induced nephropathy in parenteral challenge tests for allergy evaluation of hypersensitivity reactions to iodinated contrast media. Clin Exp Allergy. 2020; 50(10): 1200-1203.
- 100Richards M, Ferber J, Chen H, et al. Caesarean delivery and the risk of atopic dermatitis in children. Clin Exp Allergy. 2020; 50(7): 805-814.
- 101Wei YH, Tai YH, Dai YX, Chang YT, Chen TJ, Chen MH. Bidirectional association between alopecia areata and atopic dermatitis: A population-based cohort study in Taiwan. Clin Exp Allergy. 2020; 50(12): 1406-1414.
- 102Yang H, Chen JS, Zou WJ, et al. Vitamin A deficiency exacerbates extrinsic atopic dermatitis development by potentiating type 2 helper T cell-type inflammation and mast cell activation. Clin Exp Allergy. 2020; 50(8): 942-953.
- 103Guseva D, Rudrich U, Kotnik N, et al. Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy. 2020; 50(5): 577-584.
- 104Hurault G, Dominguez-Huttinger E, Langan SM, Williams HC, Tanaka RJ. Personalized prediction of daily eczema severity scores using a mechanistic machine learning model. Clin Exp Allergy. 2020; 50(11): 1258-1266.
- 105Scala E, Abeni D, Guerra EC, et al. beta-1,3-glucanase rOle e 9 and MnSOD rAsp f 6 IgE reactivity are the signature of atopic dermatitis in the Mediterranean area. Clin Exp Allergy. 2020; 50(4): 487-498.
- 106Umayahara T, Shimauchi T, Iwasaki M, et al. Protective role of Galectin-7 for skin barrier impairment in atopic dermatitis. Clin Exp Allergy. 2020; 50(8): 922-931.
- 107Maurer M, Costa C, Gimenez Arnau A, et al. Antihistamine-resistant chronic spontaneous urticaria remains undertreated: 2-year data from the AWARE study. Clin Exp Allergy. 2020; 50(10): 1166-1175.
- 108Hofman ZLM, van den Elzen MT, Kuijpers J, et al. Evidence for bradykinin release in chronic spontaneous urticaria. Clin Exp Allergy. 2020; 50(3): 343-351.
- 109Sabag DA, Matanes L, Bejar J, et al. Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria. Clin Exp Allergy. 2020; 50(7): 799-804.
- 110Alizadeh Aghdam M, Knol EF, van den Elzen M, et al. Response of FcepsilonRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria. Clin Exp Allergy. 2020; 50(3): 364-371.
- 111Whyte AF, Popescu FD, Carlson J. Tabanidae insect (horsefly and deerfly) allergy in humans: a review of the literature. Clin Exp Allergy. 2020; 50(8): 886-893.
- 112Monday ST, David NA, Zarkesh Esfahani SA, et al. Measurement of German cockroach allergens and their isoforms in allergen extracts with mass spectrometry. Clin Exp Allergy. 2020; 50(6): 741-751.
- 113Klueber J, Costa J, Randow S, et al. Homologous tropomyosins from vertebrate and invertebrate: recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods. Clin Exp Allergy. 2020; 50(1): 105-116.
- 114da Silva ES, Atlas L, Pinheiro CS, et al. A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate. Clin Exp Allergy. 2020; 50(7): 835-847.
- 115Erlewyn-Lajeunesse M, Alviani C, Cross S, Grainger-Allen E. Further considerations for venom immunotherapy following the withdrawal of Pharmalgen. Clin Exp Allergy. 2020; 50(9): 1111-1112.
- 116Jogi NO, Kleppe Olsen R, Svanes C, et al. Prevalence of allergic sensitization to storage mites in Northern Europe. Clin Exp Allergy. 2020; 50(3): 372-382.
- 117Jones CJ, Mabbitt J, Kissling E, et al. Measuring the proportion of and reasons for asthma-related school absence in England. Clin Exp Allergy. 2020; 50(6): 752-755.
- 118Kang LJ, Vu KN, Koleva PT, et al. Maternal psychological distress before birth influences gut immunity in mid-infancy. Clin Exp Allergy. 2020; 50(2): 178-188.
- 119Schools AM, Hansen BR, Stokholm J, Chaves BL, Bonnelykke K, Bisgaard H. Parent-specific effects on risk of developing allergic sensitization and asthma in childhood. Clin Exp Allergy. 2020; 50(8): 915-921.
- 120Ruokolainen L, Fyhrquist N, Laatikainen T, et al. Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence. Clin Exp Allergy. 2020; 50(10): 1148-1158.
- 121van Meel ER, Jaddoe VWV, Reiss IKM, et al. The influence of Epstein-Barr virus and cytomegalovirus on childhood respiratory health: a population-based prospective cohort study. Clin Exp Allergy. 2020; 50(4): 499-507.
- 122Brooks C, Slater T, Corbin M, et al. Respiratory health in professional cleaners: symptoms, lung function, and risk factors. Clin Exp Allergy. 2020; 50(5): 567-576.
- 123Ji Y, Bourke SJ, Spears M, et al. Krebs von den Lungen-6 (KL-6) is a pathophysiological biomarker of early-stage acute hypersensitivity pneumonitis among pigeon fanciers. Clin Exp Allergy. 2020; 50(12): 1391-1399.
- 124Sekiya R, Nagano T, Moriyama T, et al. Occupational respiratory allergy to lettuce in lettuce farmers. Clin Exp Allergy. 2020; 50(8): 932-941.
- 125Alahmadi F, Peel A, Keevil B, Niven R, Fowler SJ. Assessment of adherence to corticosteroids in asthma by drug monitoring or fractional exhaled nitric oxide: a literature review. Clin Exp Allergy. 2021; 51(1): 49-62.
- 126Bidovec-Stojkovic U, Vachova M, Kosnik Z, et al. Methodological and diagnostic relevance of IgEs to recombinant allergens Api m 1 and Ves v 5 determined by the multiplex test ImmunoCAP ISAC. Clin Exp Allergy. 2020; 50(8): 981-983.
- 127Blais CM, Davis BE, Cockcroft DW. The effect of deep inhalation on mannitol responsiveness. Clin Exp Allergy. 2020; 50(3): 308-314.
- 128Comberiati P, Spahn JD, Paull K, Faino A, Cherniack R, Covar RA. Lung mechanical properties distinguish children with asthma with normal and diminished lung function. Clin Exp Allergy. 2020; 50(4): 453-462.
- 129Eickmeier O, Zissler UM, Wittschorek J, et al. Clinical relevance of Aspergillus fumigatus sensitization in cystic fibrosis. Clin Exp Allergy. 2020; 50(3): 325-333.
- 130Hoshino M, Akitsu K, Kubota K, Ottawa J. Association between biomarkers and house dust mite sublingual immunotherapy in allergic asthma. Clin Exp Allergy. 2020; 50(9): 1035-1043.
- 131Roman-Carrasco P, Hemmer W, Klug C, et al. Individuals with IgE antibodies to alpha-Gal and CCD show specific IgG subclass responses different from subjects non-sensitized to oligosaccharides. Clin Exp Allergy. 2020; 50(9): 1107-1110.
- 132Shams MH, Assarehzadegan MA, Eskandari N, et al. Molecular and immunochemical characterization of Pop n 2: a new allergen of Populus nigra pollen. Clin Exp Allergy. 2020. https://doi.org/10.1111/cea.13789
- 133Vidal C, Armisen M, Monsalve R, et al. Vesp v 5 and glycosylated Vesp v 1 are relevant allergens in Vespa velutina nigrithorax anaphylaxis. Clin Exp Allergy. 2020; 50(12): 1424-1427.
- 134Ehrenberg AE, Klingebiel C, Ostling J, et al. Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species. Clin Exp Allergy. 2020; 50(8): 964-972.
- 135Okuda R, Takemura T, Mikami Y, et al. Inhalation challenge test using pigeon eggs for chronic hypersensitivity pneumonitis. Clin Exp Allergy. 2020; 50(12): 1381-1390.
- 136de Graaf NPJ, Bontkes HJ, Roffel S, et al. Non-heat inactivated autologous serum increases accuracy of in vitro CFSE lymphocyte proliferation test (LPT) for nickel. Clin Exp Allergy. 2020; 50(6): 722-732.
- 137Ramos-Ramirez P, Norby M, Liu J, et al. A new house dust mite-driven and mast cell-activated model of asthma in the guinea pig. Clin Exp Allergy. 2020; 50(10): 1184-1195.
- 138El RR, Anhe GF, Page CP, Riffo-Vasquez Y. Sex differences in the influence of obesity on a murine model of allergic lung inflammation. Clin Exp Allergy. 2020; 50(2): 256-266.
- 139Jacquard C, Oulehri W, Collange O, et al. Treatment with a platelet-activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock. Clin Exp Allergy. 2020; 50(3): 383-390.
- 140Brandt EB, Bolcas PE, Ruff BP, Khurana Hershey GK. TSLP contributes to allergic airway inflammation induced by diesel exhaust particle exposure in an experimental model of severe asthma. Clin Exp Allergy. 2020; 50(1): 121-124.
- 141Kropp L, Jackson-Thompson B, Thomas LM, McDaniel D, Mitre E. Chronic infection with a tissue-invasive helminth attenuates sublethal anaphylaxis and reduces granularity and number of mast cells. Clin Exp Allergy. 2020; 50(2): 213-221.
- 142Salka K, Arroyo M, Chorvinsky E, et al. Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life. Clin Exp Allergy. 2020; 50(9): 1044-1054.
- 143Lambert KA, Katelaris C, Burton P, et al. Tree pollen exposure is associated with reduced lung function in children. Clin Exp Allergy. 2020; 50(10): 1176-1183.
- 144Diwakar L, Cummins C, Roberts T. Understanding parent preferences for NHS paediatric allergy services. Clin Exp Allergy. 2020; 50(10): 1159-1165.
- 145Knibb RC, Gore C. Challenges for transition from paediatric to adult services for young people with allergic conditions in the United Kingdom. Clin Exp Allergy. 2020; 50(10): 1120-1121.
- 146Krishna MT, Hackett S, Bethune C, Fox AT. Achieving equitable management of allergic disorders and primary immunodeficiency in a Black, Asian and Minority Ethnic population. Clin Exp Allergy. 2020; 50(8): 880-883.
- 147Williams F, Ponsford M, El-Shanawany T, Macdonald L, Jolles S, Williams P. Improved anaphylaxis referral rates to specialized services from an Emergency Department. Clin Exp Allergy. 2020; 50(8): 973-976.