The cover image is based on the Original Article A novel method to improve the osteogenesis capacity of hUCMSCs with dual-directional pre-induction under screened co-culture conditions by Qiong Rong et al., https://doi.org/10.1111/cpr.12740.

The cover image is based on the Review Active interfacial dynamic transport of fluid in a network of fibrous connective tissues throughout the whole body by Hongyi Li et al., https://doi.org/10.1111/cpr.12760.

The cover image is based on the Original Article Blockade of JAK2 protects mice against hypoxia-induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation by Lei Zhang et al., https://doi.org/10.1111/cpr.12742.

The cover image is based on the Original Article Icariin prevents oestrogen deficiency–induced alveolar bone loss through promoting osteogenesis via STAT3 by Hongyuan Xu et al., https://doi.org/10.1111/cpr.12743.

We summarize the regulation of the proliferation and differentiation of embryonic stem cells by adjusting bioengineered microenvironment, to make ex vivo culture of natural embryos and self-assembly of embryonic stem cells mimic embryonic development in vivo, and future challenges are discussed finally.