In this prospective longitudinal serological survey of COVID-19 antibody in pediatric solid organ transplant recipients, we observed a detectable humoral response following two doses of COVID-19 mRNA vaccine and, importantly, with enhanced responses following additional doses of vaccine, as measured by multiple serologic assays.
This paper provides an overview of neurocognitive functioning in youth with end-stage organ dysfunction with discussion of implications for adolescent transplant recipients. While neurocognitive functioning may improve post-transplantation, it is important to understand the trajectory of neurocognitive development starting in transplant candidacy to evaluate the implications of early deficits.
D+R− serostatus is significantly associated with the development of monomorphic/polymorphic PTLD. Intensive follow-up of EBV viral load within 6-month post-transplant, especially for patients with D+R− and/or non-liver transplant recipients ≥5 years of age at transplant, may help detect monomorphic/polymorphic PTLD early in pediatric transplant.
Excellent short- and long-term kidney transplant graft, gut transplant graft, and patient survival can be achieved through meticulous surgical technique and multidisciplinary peri-operative management of pediatric kidney after gut transplant recipients.
To evaluate immunization practice among ERN-TransplantChild centers. Cross-sectional questionnaire 27 ERN-TransplantChild centers: 28 SOT programs, 6 HSCT programs. PRE: At the time of transplantation, pediatric candidates were fully immunized (80%–100%) in 57% and 33% of the SOT and HSCT programs. Variations in the time between vaccine administration and admission to the waiting list were reported between the centers. POST: Almost all sites recommended immunization in the post-transplant period, with a time window of 4–8 months for the inactivated vaccines and 16–24 months for MMR and Varicella vaccines. Only five sites administer LAVs after transplantation, with seroconversion evaluated in 80% of cases. The immunization coverage of EU pediatric transplant recipients is still inconsistent and inadequate. This survey is a starting point for developing shared evidence-based immunization protocols for safe vaccination and generating new research studies.
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