Reproductive Medicine and Biology Best Article Award

9 January 2024
9 January 2024

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2024

Open Access

An approach for live imaging of first cleavage in mouse embryos using fluorescent chemical probes for DNA, microtubules, and microfilaments

Motonari Okabe,  Hiromitsu Shirasawa,  Yuki Ono,  Mayumi Goto,  Takuya Iwasawa,  Taichi Sakaguchi,  Akiko Fujishima,  Yohei Onodera,  Kenichi Makino,  Hiroshi Miura,  Yukiyo Kumazawa,  Kazumasa Takahashi,  Yukihiro Terada, 
Open Access

Impact of administering umbilical cord-derived mesenchymal stem cells to cynomolgus monkeys with endometriosis

Shunichiro Tsuji,  Takeo Mukai,  Hideaki Tsuchiya,  Chizuru Iwatani,  Akiko Nakamura,  Tokiko Nagamura-Inoue,  Takashi Murakami, 
Open Access

Prominin-1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice

Haruka Matsukuma,  Yuka Kobayashi,  Shintaro Oka,  Fumiaki Higashijima,  Kazuhiro Kimura,  Erika Yoshihara,  Noriaki Sasai,  Koji Shiraishi, 
Prominin-1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice

This study reveals a role of Prominin-1 (PROM1) in spermatogenesis. Prominin-1 is a stem cell marker that promotes cell proliferation, migration, and inhibition of apoptosis. PROM1 KO mice showed testicular atrophy and abnormal sperm flagella. Prominin-1 deletion may cause impaired spermatogenesis and flagellum formation.

2023

Open Access

TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility

Yuki Oyama,  Haruhiko Miyata,  Keisuke Shimada,  Tamara Larasati,  Yoshitaka Fujihara,  Masahito Ikawa, 
TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility

Observation of sperm morphology in the testis with scanning and transmission electron microscopy (SEM and TEM).

Open Access

Single-cell profiling of transcriptomic changes during in vitro maturation of human oocytes

Hiroki Takeuchi,  Mari Yamamoto,  Megumi Fukui,  Akihiro Inoue,  Tadashi Maezawa,  Mikiko Nishioka,  Eiji Kondo,  Tomoaki Ikeda,  Kazuya Matsumoto,  Kei Miyamoto, 
Single-cell profiling of transcriptomic changes during in vitro maturation of human oocytes

In vitro maturation of human oocytes is used for infertility treatment, but molecular mechanisms underlying successful maturation remain unclear. In this study, we reveal transcriptomes of human oocytes during in vitro maturation by singlecell RNA-seq analyses and identify maturation stage-specific transcripts.

Open Access

Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice

Yuki Hiradate,  Ryua Harima,  Rin Yanai,  Kenshiro Hara,  Kazue Nagasawa,  Makoto Osada,  Tomoe Kobayashi,  Makoto Matsuyama,  Shin-ichiro Kanno,  Akira Yasui,  Kentaro Tanemura, 
Loss of Axdnd1 causes sterility due to impaired spermatid differentiation in mice

AXDND1 expression in early spermiogenesis. Observations of different stages of seminiferous tubules demonstrated cytoplasmic expression of the protein from spermatocytes to elongated spermatids.