Frontrunners in Cancer Medicine

Jan 1, 2019
28 January 2019

We are proud to present this virtual issue of Cancer Medicine, highlighting key global papers that we have published recently, primarily relating to translational studies. This issue will be of interest to all clinical oncologists, as well as to researchers and policy makers working in oncology.

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Cancer Biology

Original Research

Open Access

Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma

Tao Cai,  Yu Liu,  Jie Xiao, 
Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma

Our study demonstrates that MALAT1 knockdown reverses TMZ resistance by up-regulating miR-101 regulatory network. And, our findings indicate that MALAT1 may be a prognostic molecular marker and potentional target for GBM TMZ-based chemotherapy.