25th Anniversary

25 May 2025
26 May 2025

Celebrating 25 Years of Macromolecular Bioscience

Since its launch in 2000, Macromolecular Bioscience has been at the forefront of interdisciplinary research, publishing cutting-edge studies at the intersection of polymer science and the life sciences. Over the past 25 years, the journal has evolved into a trusted platform for groundbreaking work in biomaterials, drug delivery, tissue engineering, and molecular medicine—driven by the passion and innovation of scientists worldwide.

To mark this milestone anniversary, we are proud to present a special virtual collection of curated articles that reflect the journal’s rich history and its impact on the field. These selected contributions highlight key developments and emerging trends, showcasing the creativity and scientific excellence that define Macromolecular Bioscience.

We thank our authors, reviewers, and readers for being an integral part of this journey. As we look to the future, we remain committed to supporting pioneering research and fostering a vibrant scientific community. We hope you enjoy revisiting these highlights and continue to explore the breakthroughs yet to come.

Articles

Open Access

Electrospinning of Cellulose Benzyl Carbamates for Enantioselective Membrane Filtration

Electrospinning of Cellulose Benzyl Carbamates for Enantioselective Membrane Filtration

Aromatic cellulose derivatives, namely cellulose benzyl carbamate (CBzC) and cellulose 4-chlorobenzyl carbamate (CCBzC), are synthesized as a new type of polysaccharide-based chiral selectors (CSs) by a modular synthesis approach. These CSs are electrospun for the first time to form self-standing nanofibrous membranes. Their enantioselective permeation properties are investigated experimentally by liquid–liquid permeations and theoretically by molecular docking simulations.

Open Access

4-O-Methylglucuronoxylan from Hygrophila Ringens var. Ringens Seeds: Chemical Composition and Anti-Inflammatory Activity

4-O-Methylglucuronoxylan from Hygrophila Ringens var. Ringens Seeds: Chemical Composition and Anti-Inflammatory Activity

4-O-Methylglucuronoxylan from Hygrophila ringens var. ringens is found to inhibit the serum albumin denaturation, inflammatory cytokines, and release of reactive oxygen species by activation of mitogen-activated protein kinases without having significant macrophage cytotoxicity. Inhibition is mediated by the activation of mitogen-activated protein kinases by inhibiting the phosphorylation of p38 and extracellular signal-regulated kinase.

Open Access

Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications

Polymeric Nanoarchitectures: Advanced Cargo Systems for Biological Applications

This review highlights the self-assembly of amphiphilic block copolymers into micelles and polymersomes, emphasizing their precisely tunable properties for a wide range of biomedical applications, including drug delivery, diagnostics, and the creation of artificial cells. Additionally, it offers a reflective analysis of the current state of polymer-based cargo carriers, shedding light on both the opportunities and challenges that shape their future development.

Open Access

A Supramolecular, Triple Negative Breast Cancer-Targeting Avidin-Photosensitizer

A Supramolecular, Triple Negative Breast Cancer-Targeting Avidin-Photosensitizer

This study investigates the targeted delivery of photosensitizers in triple-negative breast cancer (TNBC) using a Ru-NH2-modified avidin bioconjugate (RuAvi). RuAvi binds to the cinnamoyl peptide, F(D)LF(D)LFK-NH2 (FK), targeting the formyl peptide receptor 1, which is overexpressed in TNBC. The resulting FK4-RuAvi shows enhanced internalization and significant phototoxicity in TNBC cells and spheroids, which is promising for targeted PDT.

Open Access

Biodegradable Polymers for Plant Nutrient Delivery and Recovery

Biodegradable Polymers for Plant Nutrient Delivery and Recovery

This review article discusses the use of biodegradable polymers to address several grand challenges in agriculture: to improve the delivery of nitrogen and phosphorous to crops, to optimize plant uptake, and to enhance the recovery of these nutrients from wastewater, to recycle them and reduce water pollution.

Open Access

Polypept(o)ide-Based Core–Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation

Polypept(o)ide-Based Core–Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation

This study developed polypept(o)ide-based core–shell brushes (CSBs) with tunable sizes (Rh: 17–70 nm) for hydrophobic drug delivery. CSBs achieved 10% dasatinib loading through ππ interactions, enabling sustained release over 72 h. Notably, CSB-dasatinib complexes showed comparable cell viability reduction to the free drug in U-87 MG cells, demonstrating its potential for advanced cancer therapy.

Open Access

Triblock Polyampholyte-Based Nanovesicles for Targeted Spleen Delivery

Triblock Polyampholyte-Based Nanovesicles for Targeted Spleen Delivery

Polymeric nanovesicles, assembled from triblock polyampholytes, exhibit unilamellar structure and enhanced stability through membrane cross-linking. These nanovesicles demonstrate prolonged blood circulation and selective accumulation in the spleen after intravenous injection in mice, highlighting their potential for targeted drug delivery applications.