We established the correlation between the spin polarization observed due to the chiral induced spin selectivity (CISS) effect and the dissymmetry factor of the molecules. Hence, the manuscript provides new insight into the mechanism of the CISS effect.

One kind of the supramolecular system shows selectivity for planar and nonplanar molecules as well as azahelicenium enantiomers, leading to prominent circularly polarized luminescence performance with |g_lum| of close to 0.01.

Amyloid-β, which is believed to cause Alzheimer's disease, is cleared by exosomes. To increase exosome production, stereochemistry of the C3 position in the ceramide as a stimulant material of it must be in the R configuration.

The origin of enantiomeric discrimination arising because of the interaction between gold tetrahelices and molecules with helical chirality is explained based on scattered field enhancement. Weakly scattering chiral molecules are detectable in the near vicinity of gold tetrahelices upon illumination by a plane polarized electromagnetic wave.

Approximating the exponential form of the Mueller matrix to higher-order (i.e., higher accuracy) reveals spurious contributions to circular dichroism spectra. We demonstrate that highly anisotropic samples are most susceptible to these interference effects, which, unlike LDLB effects, cannot be removed from spectra through averaging.

Molecules that are chiral by virtue of deuterium substitution are often prepared by precision deuteration chemistry. A new method to establish the absolute configuration of these enantioisotopomers by chiral tag rotational spectroscopy is described.

This work finds the best coordinate origin for length gauge optical rotation calculations. We propose a straightforward procedure to find this coordinate origin, and we show that this choice is transferable across levels of theory.

What kinds of distortions of a linear chromophore are most generative of optical activity? It is shown that bending, a decidedly achiral, in-plane deformation, is strongly generative of gyration in oriented structures whereas the subsequent introduction of helical twisting serves only to diminish the initial response.

The dispersive optical activity of two flexible aliphatic amines was measured under isolated and solvated conditions with variants of the independent-conformer ansatz used to interpret findings. Although reasonable vapor-phase predictions of ensemble-averaged response were possible, poor simulations of solution-phase behavior were attributed to a putative breakdown of the isolated-conformer premise.

Chiral spirobifluorenes (SBFs) can be used to create chiroptical systems with high thermal stability and chiroptical responses. Some recent examples are as follows: SBFs with metal-containing aromatic rings, tetracyanobutadiene SBFs, SBFs with tunable spiroconjugation, all-carbon double helices, flexible shape-persistent macrocycles, and macrocycles presenting helical molecular orbitals.