Age at menarche, ideal cardiovascular health metrics, and risk of diabetes in adulthood: Findings from the REACTION study
月经初潮年龄、理想的心血管健康指标和成年后糖尿病患病风险:来自REACTION研究的发现
Chunyan Hu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYi Zhang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJie Zhang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYanan Huo
Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China
Search for more papers by this authorQin Wan
The Affiliated Hospital of Luzhou Medical College, Luzhou, China
Search for more papers by this authorMian Li
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorHongyan Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorRui Du
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuanyue Zhu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYingfen Qin
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorRuying Hu
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorLixin Shi
Affiliated Hospital of Guiyang Medical College, Guiyang, China
Search for more papers by this authorQing Su
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Search for more papers by this authorXuefeng Yu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorLi Yan
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Search for more papers by this authorGuijun Qin
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Search for more papers by this authorXulei Tang
The First Hospital of Lanzhou University, Lanzhou, China
Search for more papers by this authorGang Chen
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
Search for more papers by this authorMin Xu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorTiange Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorZhiyun Zhao
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuhong Chen
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorGuixia Wang
The First Hospital of Jilin University, Changchun, China
Search for more papers by this authorFeixia Shen
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorZuojie Luo
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorQiang Li
The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Search for more papers by this authorZhen Ye
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorYinfei Zhang
Central Hospital of Shanghai Jiading District, Shanghai, China
Search for more papers by this authorChao Liu
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China
Search for more papers by this authorYoumin Wang
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorShengli Wu
Karamay Municipal People's Hospital, Xinjiang, China
Search for more papers by this authorTao Yang
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Search for more papers by this authorHuacong Deng
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Search for more papers by this authorLulu Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorJiajun Zhao
Shandong Provincial Hospital affiliated to Shandong University, Jinan, China
Search for more papers by this authorYiming Mu
Chinese People's Liberation Army General Hospital, Beijing, China
Search for more papers by this authorWeiqing Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYu Xu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYufang Bi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Jieli Lu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence
Jieli Lu, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China.
Email: [email protected]
Search for more papers by this authorGuang Ning
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorfor the REACTION Study Group
Search for more papers by this authorChunyan Hu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYi Zhang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJie Zhang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYanan Huo
Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China
Search for more papers by this authorQin Wan
The Affiliated Hospital of Luzhou Medical College, Luzhou, China
Search for more papers by this authorMian Li
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorHongyan Qi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorRui Du
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuanyue Zhu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYingfen Qin
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorRuying Hu
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorLixin Shi
Affiliated Hospital of Guiyang Medical College, Guiyang, China
Search for more papers by this authorQing Su
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Search for more papers by this authorXuefeng Yu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorLi Yan
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Search for more papers by this authorGuijun Qin
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Search for more papers by this authorXulei Tang
The First Hospital of Lanzhou University, Lanzhou, China
Search for more papers by this authorGang Chen
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
Search for more papers by this authorMin Xu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorTiange Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorZhiyun Zhao
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuhong Chen
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorGuixia Wang
The First Hospital of Jilin University, Changchun, China
Search for more papers by this authorFeixia Shen
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorZuojie Luo
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorQiang Li
The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Search for more papers by this authorZhen Ye
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorYinfei Zhang
Central Hospital of Shanghai Jiading District, Shanghai, China
Search for more papers by this authorChao Liu
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China
Search for more papers by this authorYoumin Wang
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorShengli Wu
Karamay Municipal People's Hospital, Xinjiang, China
Search for more papers by this authorTao Yang
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Search for more papers by this authorHuacong Deng
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Search for more papers by this authorLulu Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorJiajun Zhao
Shandong Provincial Hospital affiliated to Shandong University, Jinan, China
Search for more papers by this authorYiming Mu
Chinese People's Liberation Army General Hospital, Beijing, China
Search for more papers by this authorWeiqing Wang
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYu Xu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYufang Bi
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorCorresponding Author
Jieli Lu
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence
Jieli Lu, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China.
Email: [email protected]
Search for more papers by this authorGuang Ning
Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorfor the REACTION Study Group
Search for more papers by this authorFunding information: Shanghai Medical and Health Development Foundation, Grant/Award Number: DMRFP_I_01; Shanghai Outstanding Academic Leaders Plan, Grant/Award Numbers: 18XD1402500, 20XD1422800; the National Major Scientific and Technological Special Project for “Significant New Drugs Development”, Grant/Award Number: 2017ZX09304007; the Ministry of Science and Technology of the People's Republic of China, Grant/Award Numbers: 2016YFC1304904, 2016YFC1305202, 2016YFC1305600, 2016YFC0901200, 2017YFC1310700, 2018YFC1311800; the National Natural Science Foundation of China, Grant/Award Numbers: 81561128019, 81670795, 81700764, 81970691, 81970728
Abstract
enBackground
Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear.
Methods
We included 121 431 women from the nationwide, population-based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes.
Results
The multivariable-adjusted odds ratios of diabetes across categories of age at menarche (<14, 14-17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes (P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs (P for interaction = .0001).
Conclusions
Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results.
摘要
zh背景
既往研究提示月经初潮年龄与糖尿病风险有关。然而尚不清楚理想的心血管健康指标对月经初潮年龄与成年后糖尿病风险之间关系的影响。
方法
我们纳入全国多中心REACTION研究(中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究)中121431名女性。糖尿病的诊断基于口服葡萄糖耐量试验和糖化血红蛋白测值。使用Logistic回归和乘法项交互作用分析理想的心血管健康指标在月经初潮年龄与糖尿病相关性之间的潜在交互作用。
结果
多变量校正后; 与月经初潮年龄14-17岁者相比; 月经初潮年龄<14岁和> 17岁组的糖尿病风险比值比(95%可信区间)分别为1.22(1.17-1.28)和0.89(0.85-0.93)。分层分析中; 在总胆固醇; 血压水平和月经初潮年龄与糖尿病风险之间存在显著的交互作用(交互作用P 值分别为 0.0091和0.0019)。在有≤3个理想的心血管健康指标的女性中观察到月经初潮年龄<14岁与成年后糖尿病发生风险增加显著相关; 但在有4个或更多理想的心血管健康指标的女性中则没有观察到显著的风险增加(理想的心血管健康指标的数量与月经初潮年龄之间的交互作用P值 = 0.0001)。
结论
女性成年后患糖尿病的风险与月经初潮年龄呈负相关; 而这种关系或可因理想的心血管健康指标而改变。需进一步研究以阐明其中的相互关系以及研究结果的普遍性。
CONFLICT OF INTERESTS
The authors declare that there is no duality of interest associated with this manuscript.
Supporting Information
| Filename | Description |
|---|---|
| jdb13128-sup-0001-supinfo.docxWord 2007 document , 29 KB | Appendix S1. Supporting information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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