Comparing the effects of 6 months aerobic exercise and resistance training on metabolic control and β-cell function in Chinese patients with prediabetes: A multicenter randomized controlled trial†6个月的有氧和抗阻运动对糖尿病前期人群代谢控制和胰岛β细胞功能的影响——一项多中心随机对照研究
Abstract
enBackground
It is clear that aerobic training (AT) can delay pancreatic exhaustion and slow the progression from prediabetes to type 2 diabetes (T2D), but there is little information regarding the effects of resistance training (RT) in people with prediabetes. This study compared the effectiveness of RT and AT in improving metabolic control and protecting β-cell function in people with prediabetes.
Methods
Chinese subjects (n = 248) with prediabetes were randomized to three groups: AT (n = 83), RT (n = 82) and control (n = 83). Subjects in the RT group performed 13 different resistance exercises per session using an elastic string. Those in the AT group performed aerobic exercises at 60%-70% of maximum heart rate. In both cases, exercises were performed three times per week for a period of 6 months. The primary outcome was improvement in metabolic control. Longitudinal changes between groups were tested using repeated-measures analysis of variance.
Results
Of the initial 248 participants, 217 finished the study, but all participants were included in the intention-to-treat analyses. There were no significant differences in demographic characteristics among the RT, AT, and control groups (P > 0.05). Changes in HbA1c were not significantly greater in RT than AT cohort (P = 0.059), but the decrease in HbA1c in both exercise groups was higher than in the control group (P < 0.05).
Conclusions
In subjects with prediabetes, RT appears to improve metabolic control and preserve β-cell function comparable to AT.
摘要
zh目的
已有研究表明有氧运动(aerobic training, AT)能够延迟胰岛衰竭并减慢从糖尿病前期到2型糖尿病(type 2 diabetes, T2D)的发展进程, 但是关于抗阻运动(resistance training, RT)对糖尿病前期人群的作用, 信息甚少。此研究比较了RT和AT在改善糖尿病前期人群代谢指标控制和保护胰岛β细胞功能方面的有效性。
方法
选取符合纳入标准的糖尿病前期人群248例, 随机分为AT组83例, RT组82例, 对照组83例。RT组人群使用弹力绳每节进行13种不同动作的抗阻运动, AT组人群采用有氧操运动形式以达到最大心率的60%~70%。两组人群运动频率均为每周3次, 总计干预6个月。主要终点是代谢控制的改善, 组之间的纵向变化利用方差的重复度量分析。
结果
248例初始患者中, 217例完成了最终研究, 数据统计分析时, 对全部248例研究对象进行了意向性分析。干预前三组的基线均衡可比, 尽管AT组与RT组间HbA1c的改善无统计学意义(P=0.059), 但与对照组相比, AT和RT均能有效改善HbA1c(P<0.05)。
结论
针对糖尿病前期人群, RT能有效改善代谢指标控制和胰岛β细胞功能, 其效果与AT相当。
