Diffuse optical detection of global cerebral ischemia in an adult porcine model
Chuhua Fu
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Department of Neurosurgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, People's Republic of China
Search for more papers by this authorDetian Wang
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorLong Wang
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Search for more papers by this authorLiguo Zhu
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorZeren Li
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorTunan Chen
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Search for more papers by this authorCorresponding Author
Hua Feng
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Correspondence
Hua Feng and Fei Li, Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing 400038, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Fei Li
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Correspondence
Hua Feng and Fei Li, Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing 400038, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorChuhua Fu
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Department of Neurosurgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, People's Republic of China
Search for more papers by this authorDetian Wang
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorLong Wang
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Search for more papers by this authorLiguo Zhu
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorZeren Li
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan, People's Republic of China
Search for more papers by this authorTunan Chen
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Search for more papers by this authorCorresponding Author
Hua Feng
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Correspondence
Hua Feng and Fei Li, Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing 400038, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Fei Li
Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing, People's Republic of China
Correspondence
Hua Feng and Fei Li, Department of Neurosurgery of Southwest Hospital, Army Medical University, Chong Qing 400038, People's Republic of China.
Email: [email protected] and [email protected]
Search for more papers by this authorChuhua Fu and Detian Wang contributed equally to the article.
Abstract
Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low-cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation (n = 5) or air emboli (n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke.
CONFLICT OF INTEREST
No conflicts of interest, financial or otherwise, are declared by the authors.
Open Research
DATA AVAILABILITY STATEMENT
The full data that support the findings of this study are available within the article and its supplementary material.
Supporting Information
| Filename | Description |
|---|---|
| jbio202200168-sup-0001-Supinfo.docxWord 2007 document , 395 KB | FIGURE S1. The changes in optical intensities and calculated μeff of an exemplar occlusion miniature pig FIGURE S2. The changes in StO2 and HbT of an exemplar occlusion miniature pig FIGURE S3. The hemodynamic changes versus time for the five miniature pigs FIGURE S4. The changes in optical intensities and calculated μeff of an exemplar executed miniature pig FIGURE S5. The changes in StO2 and HbT of an exemplar executed miniature pig FIGURE S6. The changes in BFI, StO2, and HbT versus time for the other dead pig TABLE S1. The statistic results for absolute BFI, StO2, and HbT |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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