Reconnectable fiberscopes for chronic in vivo deep-brain imaging
M. S. Pochechuev
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Search for more papers by this authorI. V. Fedotov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Department of Physics and Astronomy, Texas A&M University, College Station, Texas
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorO. I. Ivashkina
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Search for more papers by this authorM. A. Roshchina
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Search for more papers by this authorD.V. Meshchankin
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Search for more papers by this authorD. A. Sidorov-Biryukov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorA. B. Fedotov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorK. V. Anokhin
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
Search for more papers by this authorCorresponding Author
A. M. Zheltikov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Department of Physics and Astronomy, Texas A&M University, College Station, Texas
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Correspondence
Aleksei M. Zheltikov, Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia. Email: [email protected]
Search for more papers by this authorM. S. Pochechuev
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Search for more papers by this authorI. V. Fedotov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Department of Physics and Astronomy, Texas A&M University, College Station, Texas
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorO. I. Ivashkina
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Search for more papers by this authorM. A. Roshchina
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Search for more papers by this authorD.V. Meshchankin
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Search for more papers by this authorD. A. Sidorov-Biryukov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorA. B. Fedotov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Search for more papers by this authorK. V. Anokhin
Kurchatov Institute National Research Center, Moscow, Russia
Russian Quantum Center, Skolkovo, Russia
P.K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia
Search for more papers by this authorCorresponding Author
A. M. Zheltikov
Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia
Kurchatov Institute National Research Center, Moscow, Russia
Department of Physics and Astronomy, Texas A&M University, College Station, Texas
Russian Quantum Center, Skolkovo, Russia
Kazan Quantum Center, A.N. Tupolev Kazan National Research Technical University, Kazan, Russia
Correspondence
Aleksei M. Zheltikov, Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Moscow, Russia. Email: [email protected]
Search for more papers by this authorAbstract
Reconnectable bundles consisting of thousands of optical fibers are shown to enable high-quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers as well as axon growth regulators and brain-specific protein drivers in deep regions of live brain.
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