Tough and Enzyme-Degradable Hydrogels
Ginger Chen
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorShadi Taghavi
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorDale Marecak
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorCorresponding Author
Brian G. Amsden
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
E-mail: [email protected]Search for more papers by this authorGinger Chen
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorShadi Taghavi
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorDale Marecak
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
Search for more papers by this authorCorresponding Author
Brian G. Amsden
Department of Chemical Engineering, Queen's University Kingston, Kingston, ON, K7L 3N6 Canada
E-mail: [email protected]Search for more papers by this authorAbstract
Mechanically robust hydrogels that degrade only via cell action have potential as scaffolds for the generation of load-bearing soft connective tissue. This study demonstrates that terminally acrylated 4-arm-poly(ethylene glycol)-block-oligo(trimethylene carbonate) (4a-PEG-(TMC)n) can be readily reacted with a collagenase-degradable bis-cysteine peptide to form hydrogels. The inclusion of the TMC blocks renders the hydrogels mechanically tough when tested under compression, with modulus and toughness values within the range of those of articular cartilage. Moreover, the hydrogels formed are resistant to degradation by hydrolysis in the absence of collagenase but degrade via surface erosion in the presence of collagenase. The strategy employed to form these hydrogels is readily tailored to create a variety of tough, enzyme-degradable hydrogels of varying mechanical and degradation properties.
Conflict of Interest
The authors declare no conflict of interest.
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