Serum Raman spectroscopy can be used to screen patients with early rheumatoid arthritis
Tianxing Lian
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorCorresponding Author
Gang Liu
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Correspondence
Gang Liu, Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Email: [email protected]
Search for more papers by this authorBo Qu
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorXun Xia
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorZixuan Yang
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorLiping Wang
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorLin Huang
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorXiaokai Wang
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorTianxing Lian
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorCorresponding Author
Gang Liu
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Correspondence
Gang Liu, Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Email: [email protected]
Search for more papers by this authorBo Qu
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorXun Xia
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorZixuan Yang
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorLiping Wang
Department of Orthopedics, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Search for more papers by this authorLin Huang
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorXiaokai Wang
School of Clinical Medicine, Chengdu Medical College, Chengdu, China
Department of Neurosurgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Search for more papers by this authorAbstract
In this study, Raman spectroscopy was used to analyze the serum of patients with early rheumatoid arthritis (RA), and to explore the screening value of Raman spectroscopy in patients with early RA. A total of 216 patients were included in the study. Fasting venous blood was collected for routine biochemical detection, and the remaining samples were tested by serum Raman spectroscopy. Support vector machine was used for model building and training. The area under the curve (AUC) values of the model were as follows: (1) healthy group versus early RA group: 0.860, (2) healthy group versus non-early RA group: 0.903, and (3) early RA group versus non-early RA group: 0.918. This study shows that serum Raman spectroscopy has a good ability to screen RA and can be staged according to the course of the disease, which can provide new ideas and technical support for the diagnosis or screening of early RA.
CONFLICT OF INTEREST
All authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
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