Assessment of the dynamics of human glymphatic system by near-infrared spectroscopy
Corresponding Author
Teemu Myllylä
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Correspondence
Teemu Myllylä, Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland.Email: [email protected]
Search for more papers by this authorMarkus Harju
Inverse Problems Group, Department of Mathematical Sciences, University of Oulu, Oulu, Finland
Search for more papers by this authorVesa Korhonen
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Search for more papers by this authorAlexander Bykov
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Department of Photonics and Optical Information Technology, ITMO University, St Petersburg, Russia
Search for more papers by this authorVesa Kiviniemi
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Search for more papers by this authorIgor Meglinski
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Department of Photonics and Optical Information Technology, ITMO University, St Petersburg, Russia
Institute of Biology, Irkutsk State University, Irkutsk, Russia
Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
Search for more papers by this authorCorresponding Author
Teemu Myllylä
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Correspondence
Teemu Myllylä, Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland.Email: [email protected]
Search for more papers by this authorMarkus Harju
Inverse Problems Group, Department of Mathematical Sciences, University of Oulu, Oulu, Finland
Search for more papers by this authorVesa Korhonen
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Search for more papers by this authorAlexander Bykov
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Department of Photonics and Optical Information Technology, ITMO University, St Petersburg, Russia
Search for more papers by this authorVesa Kiviniemi
Oulu Functional Neuroimaging Group, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland
Department of Diagnostic Radiology, Medical Research Center (MRC), Oulu University Hospital, Oulu, Finland
Search for more papers by this authorIgor Meglinski
Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
Department of Photonics and Optical Information Technology, ITMO University, St Petersburg, Russia
Institute of Biology, Irkutsk State University, Irkutsk, Russia
Institute of Engineering Physics for Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow, Russia
Search for more papers by this authorAbstract
Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with the complex organization of dural lymphatic vessels, responsible for cleaning tissue. Disturbances of glymphatic circulation are associated with several brain disorders, including dementia. This article introduces an approach to noninvasive measurement of water dynamics in the human brain utilizing near-infrared spectroscopy (NIRS). We demonstrate the possibility to sense dynamic variations of water content between the skull and grey matter, for instance, in the subarachnoid space. Measured fluctuations in water content, especially in the cerebrospinal fluid (CSF), are assumed to be correlated with the dynamics of glymphatic circulation. The sampling volume for the NIRS optode was estimated by Monte Carlo modelling for the wavelengths of 660, 740, 830 and 980 nm. In addition, using combinations of these wavelengths, this article presents the calculation models for quantifying water and haemodynamics. The presented NIRS technique allows long-term functional brain monitoring, including sleeping time. Furthermore, it is used in combination with different magnetic neuroimaging techniques, particularly magnetic resonance encephalography. Using the combined setup, we report the preliminary results on the interaction between CSF and blood oxygen level-dependent fluctuations.
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