Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue
Guanping Feng
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorMarien Ochoa
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorJason R. Maher
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorHani A. Awad
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, 14642
Search for more papers by this authorCorresponding Author
Andrew J. Berger
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
Search for more papers by this authorGuanping Feng
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorMarien Ochoa
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorJason R. Maher
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
These authors contributed equally to this work.
Search for more papers by this authorHani A. Awad
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York, 14642
Search for more papers by this authorCorresponding Author
Andrew J. Berger
The Institute of Optics, University of Rochester, 275 Hutchinson Road, Rochester, New York, 14627
Department of Biomedical Engineering, University of Rochester, 207 Robert B. Goergen Hall, Rochester, New York, 14627
Search for more papers by this authorAbstract
The development of spatially offset Raman spectroscopy (SORS) has enabled deep, non-invasive chemical characterization of turbid media. Here, we use SORS to measure subcortical bone tissue and depth-resolved biochemical variability in intact, exposed murine bones. We also apply the technique to study a mouse model of the genetic bone disorder osteogenesis imperfecta. The results suggest that SORS is more sensitive to disease-related biochemical differences in subcortical trabecular bone and marrow than conventional Raman measurements.
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