Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer: A patient biopsy analysis
Scott Palmer
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Search for more papers by this authorKarina Litvinova
Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, Aston Triangle, Birmingham, UK B4 7ET
Search for more papers by this authorAndrey Dunaev
Biomedical Photonics Instrumentation Group, Scientific-Educational Centre of “Biomedical Engineering”, Orel State University, Orel, Russia, 302020
Search for more papers by this authorJi Yubo
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Search for more papers by this authorDavid McGloin
SUPA, School of Science and Engineering, Ewing Building, University of Dundee, Nethergate, Dundee, UK DD1 4HN
Search for more papers by this authorCorresponding Author
Ghulam Nabi
- [email protected]
- (+44) 01382 660111
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Corresponding author: e-mail: [email protected], Phone: (+44) 01382 660111
Search for more papers by this authorScott Palmer
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Search for more papers by this authorKarina Litvinova
Optoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, Aston Triangle, Birmingham, UK B4 7ET
Search for more papers by this authorAndrey Dunaev
Biomedical Photonics Instrumentation Group, Scientific-Educational Centre of “Biomedical Engineering”, Orel State University, Orel, Russia, 302020
Search for more papers by this authorJi Yubo
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Search for more papers by this authorDavid McGloin
SUPA, School of Science and Engineering, Ewing Building, University of Dundee, Nethergate, Dundee, UK DD1 4HN
Search for more papers by this authorCorresponding Author
Ghulam Nabi
- [email protected]
- (+44) 01382 660111
Division of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, UK DD1 9SY
Corresponding author: e-mail: [email protected], Phone: (+44) 01382 660111
Search for more papers by this authorAbstract
Bladder cancer is among the most common cancers in the UK and conventional detection techniques suffer from low sensitivity, low specificity, or both. Recent attempts to address the disparity have led to progress in the field of autofluorescence as a means to diagnose the disease with high efficiency, however there is still a lot not known about autofluorescence profiles in the disease. The multi-functional diagnostic system “LAKK-M” was used to assess autofluorescence profiles of healthy and cancerous bladder tissue to identify novel biomarkers of the disease. Statistically significant differences were observed in the optical redox ratio (a measure of tissue metabolic activity), the amplitude of endogenous porphyrins and the NADH/porphyrin ratio between tissue types. These findings could advance understanding of bladder cancer and aid in the development of new techniques for detection and surveillance.
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