Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling
Corresponding Author
Berrend G. Muller
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Corresponding author: e-mail: [email protected]
Search for more papers by this authorDaniel M. de Bruin
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorMartin J. Brandt
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorWillemien van den Bos
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorSuzanne van Huystee
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorD. J. Faber
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorDilaria Savci
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorPatricia J. Zondervan
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorTheo M. de Reijke
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorM. Pilar Laguna-Pes
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorTon G. van Leeuwen
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorJean J. M. C. H. de la Rosette
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorCorresponding Author
Berrend G. Muller
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Corresponding author: e-mail: [email protected]
Search for more papers by this authorDaniel M. de Bruin
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorMartin J. Brandt
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorWillemien van den Bos
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorSuzanne van Huystee
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorD. J. Faber
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorDilaria Savci
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorPatricia J. Zondervan
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorTheo M. de Reijke
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorM. Pilar Laguna-Pes
Department of Urology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Z.O., The Netherlands
Search for more papers by this authorTon G. van Leeuwen
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorJean J. M. C. H. de la Rosette
Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, The Netherlands
Search for more papers by this authorAbstract
The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer.
Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package.
The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm–1; 3.85 mm–1; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor was visible in two subsequent histopathological prostate slices. This analysis could be performed in 3 patients. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.23 mm–1; 4.11 mm–1; p < 0.0001) for all patients grouped together. The area under the ROC curve was 0.89.
Functional OCT of the prostate has shown to differentiate between cancer and healthy prostate tissue. The optical attenuation coefficient in malignant tissue was significantly higher in malignant tissue compared to benign prostate tissue. Further studies are required to validate these initial results in a larger group of patients with a more tailored histopathology matching protocol.
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