CASE REPORT
Large Cell Neuroendocrine Carcinoma of the Uterine Cervix With a Biphasic Synaptophysin Staining Pattern and Followed Vaginal Intraepithelial Recurrence: A Case Report
First published: 25 July 2025
Funding: The authors received no specific funding for this work.
Graphical Abstract
This case highlights the importance of early, aggressive surgery for large cell neuroendocrine carcinoma and continuous cytological monitoring in detecting recurrence at the early intraepithelial stage. The pagetoid spread pattern with a biphasic synaptophysin staining differentiated LCNEC from CIN3 and AIS.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
