Primary Cutaneous Rosai-Dorfman Disease: A Cyto-Histo Correlate
ABSTRACT
Primary cutaneous Rosai-Dorfman disease (RDD) is a rare proliferative disorder of histiocytes involving exclusively skin. The diagnosis of cutaneous RDD relies on clinical, histopathological and immunohistochemical findings. Cytological diagnosis can also be made in the presence of diagnostic features like histiocytic proliferation and prominent emperipolesis. We present two rare cases of primary cutaneous RDD: a 20-year-old male and an 8-year-old male, diagnosed on fine-needle aspiration cytology (FNAC). The first case was multicentric with swellings on the nose and arm, while the second patient had a single swelling on the right pinna. FNAC was reported as cutaneous RDD in both cases, which was later confirmed on histopathology and immunohistochemistry.
Graphical Abstract
Primary cutaneous Rosai Dorfman disease (RDD) is a rare proliferative disorder of histiocytes involving skin exclusively. Cytomorphological features of two such cases affecting a 20-year-old male (multicentric) and an 8-year-old male are presented here. The diagnosis is challenging and a high index of suspicion and systemic correlation are necessary for early diagnosis and treatment.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
