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Unveiling Diagnostic Clues of BCOR-CCNB3 Sarcoma in Fine-Needle Aspiration Specimens

Qingjie Wang

Qingjie Wang

Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Diwei Zhou

Diwei Zhou

Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jingmin Zhong

Jingmin Zhong

Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Zhecheng Yan

Zhecheng Yan

Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Zhaorong Niu

Corresponding Author

Zhaorong Niu

Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence:

Zhaorong Niu ([email protected])

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First published: 11 June 2025

Funding: The authors received no specific funding for this work.

Graphical Abstract

BCOR-CCNB3 sarcoma is an undifferentiated small round cell sarcoma characterised by distinct molecular genetic alterations. The diagnostic clues include tumour cells with oval to short spindle-shaped morphology, finely dispersed chromatin, inconspicuous nucleoli, and an arrangement around blood vessels that forms pseudopapillary structures.

Conflicts of Interest

The authors declare no conflicts of interest.

Data Availability Statement

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

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