RESEARCH LETTER

Effect of gender on transition of normo- to microalbuminuria under angiotensin receptor blocker therapy in diabetes

血管紧张素受体拮抗剂治疗的糖尿病患者中性别对于正常白蛋白尿向微量白蛋白尿转变的影响

Florian G. Scurt

Clinic of Nephrology, Hypertension, Diabetes and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von Guericke University, Magdeburg, Germany

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Jan J. Menne,

Jan J. Menne

Nephrology Section, Hannover Medical School, Hannover, Germany

Clinic of Nephrology, Angiology and Rheumatology, KRH Klinikum Siloah, Hannover, Germany

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Alexandra Korda,

Alexandra Korda

LVR-Klinikum Düsseldorf, Heinrich, Heine, University Düsseldorf, Düsseldorf, Germany

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Hermann Haller,

Hermann Haller

Nephrology Section, Hannover Medical School, Hannover, Germany

on behalf of the ROADMAP Steering Committee

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Christos Chatzikyrkou,

Corresponding Author

Christos Chatzikyrkou

orcid.org/0000-0002-6723-2346

Clinic of Nephrology, Hypertension, Diabetes and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von Guericke University, Magdeburg, Germany

Correspondence

Christos Chatzikyrkou, Clinic of Nephrology; Hypertension, Diabetes and Endocrinology, Health Campus Immunology Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Germany.

Email: [email protected]; [email protected]

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Florian G. Scurt,

Florian G. Scurt

Clinic of Nephrology, Hypertension, Diabetes and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von Guericke University, Magdeburg, Germany

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Jan J. Menne,

Jan J. Menne

Nephrology Section, Hannover Medical School, Hannover, Germany

Clinic of Nephrology, Angiology and Rheumatology, KRH Klinikum Siloah, Hannover, Germany

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Alexandra Korda,

Alexandra Korda

LVR-Klinikum Düsseldorf, Heinrich, Heine, University Düsseldorf, Düsseldorf, Germany

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Hermann Haller,

Hermann Haller

Nephrology Section, Hannover Medical School, Hannover, Germany

on behalf of the ROADMAP Steering Committee

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Christos Chatzikyrkou,

Corresponding Author

Christos Chatzikyrkou

orcid.org/0000-0002-6723-2346

Clinic of Nephrology, Hypertension, Diabetes and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von Guericke University, Magdeburg, Germany

Correspondence

Christos Chatzikyrkou, Clinic of Nephrology; Hypertension, Diabetes and Endocrinology, Health Campus Immunology Infectiology and Inflammation, Otto-von-Guericke University Magdeburg, Germany.

Email: [email protected]; [email protected]

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First published: 04 August 2020

https://doi.org/10.1111/1753-0407.13102

The members of the ROADMAP steering committee are as follows: Sadayoshi Ito, Josphe, L. Izzo, Andrzeij Januszewicz, Shigerhiro Katayama, Jan Menne, Albert Mimram, Ton J. Rabelink, Eberhard Ritz, Luis M Ruilope, Lars C Rump, Giancarlo Viberti, and Herrmann Haller.

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Graphical Abstract

Highlights

In normoalbuminuric diabetic patients at low cardiovascular risk, the risk of transition from normo- to microalbuminuria is lower in women, despite the nonprotective effects of the angiotensin receptor blocker olmesartan.
Additional methods of assessment of albuminuria in clinical studies (eg, measurements of albumin and creatinine excretion rate) should be implemented or the actually accepted higher urine albumin creatinine ratio (UACR) cutoff values for microalbuminuria in women reconsidered.

Supporting Information

REFERENCES

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Volume12, Issue11

November 2020

Pages 856-859

Filename	Description
jdb13102-sup-0001-FigureS1.tifTIFF image, 1.5 MB	Figure S1 Baseline urine albumin creatinine ratio (UACR) predicts the response to olmesartan treatment in women and men.
jdb13102-sup-0002-TableS1.docxWord 2007 document , 18.5 KB	Table S1 Demographic data at baseline stratified by gender and treatment arm.

Effect of gender on transition of normo- to microalbuminuria under angiotensin receptor blocker therapy in diabetes

血管紧张素受体拮抗剂治疗的糖尿病患者中性别对于正常白蛋白尿向微量白蛋白尿转变的影响

Graphical Abstract

Supporting Information

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Effect of gender on transition of normo- to microalbuminuria under angiotensin receptor blocker therapy in diabetes

血管紧张素受体拮抗剂治疗的糖尿病患者中性别对于正常白蛋白尿向微量白蛋白尿转变的影响

Graphical Abstract

Supporting Information

REFERENCES

References

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