Association between smoking and glycemic control in diabetic patients: Results from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: A lONgitudinal (REACTION) study
吸烟与糖尿病患者血糖控制的相关性研究:来自中国2型糖尿病患者恶性肿瘤发生风险的纵向研究(REACTION)的发现
Kui Peng
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorGang Chen
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
These authors contributed equally to this work.Search for more papers by this authorChao Liu
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China
These authors contributed equally to this work.Search for more papers by this authorYiming Mu
Chinese People's Liberation Army General Hospital, Beijing, China
Search for more papers by this authorZhen Ye
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorLixin Shi
Affiliated Hospital of Guiyang Medical College, Guiyang, China
Search for more papers by this authorJiajun Zhao
Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
Search for more papers by this authorLulu Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorQiang Li
The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Search for more papers by this authorTao Yang
The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
Search for more papers by this authorLi Yan
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Search for more papers by this authorQin Wan
The Affiliated Hospital of Southwest Medical University, Luzhou, China
Search for more papers by this authorShengli Wu
Karamay Municipal People's Hospital, Xinjiang, China
Search for more papers by this authorGuixia Wang
The First Hospital of Jilin University, Changchun, China
Search for more papers by this authorZuojie Luo
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorXulei Tang
The First Hospital of Lanzhou University, Lanzhou, China
Search for more papers by this authorQing Su
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Search for more papers by this authorYoumin Wang
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorGuijun Qin
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Search for more papers by this authorHuacong Deng
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Search for more papers by this authorXuefeng Yu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFeixia Shen
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorLiebin Zhao
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYu Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMin Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuhong Chen
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJieli Lu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorLin Lin
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorRui Du
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMeng Dai
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMian Li
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorTiange Wang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorZhiyun Zhao
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorDi Zhang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYufang Bi
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Search for more papers by this authorCorresponding Author
Weiqing Wang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence
Weiqing Wang, National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China.
Tel: +86 21 64749885
Fax: +86 21 64749885
Email: [email protected]
Search for more papers by this authorGuang Ning
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authoron behalf of the REACTION Study Group
Search for more papers by this authorKui Peng
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorGang Chen
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
These authors contributed equally to this work.Search for more papers by this authorChao Liu
Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China
These authors contributed equally to this work.Search for more papers by this authorYiming Mu
Chinese People's Liberation Army General Hospital, Beijing, China
Search for more papers by this authorZhen Ye
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
Search for more papers by this authorLixin Shi
Affiliated Hospital of Guiyang Medical College, Guiyang, China
Search for more papers by this authorJiajun Zhao
Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
Search for more papers by this authorLulu Chen
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorQiang Li
The Second Affiliated Hospital of Harbin Medical University, Harbin, China
Search for more papers by this authorTao Yang
The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
Search for more papers by this authorLi Yan
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Search for more papers by this authorQin Wan
The Affiliated Hospital of Southwest Medical University, Luzhou, China
Search for more papers by this authorShengli Wu
Karamay Municipal People's Hospital, Xinjiang, China
Search for more papers by this authorGuixia Wang
The First Hospital of Jilin University, Changchun, China
Search for more papers by this authorZuojie Luo
The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Search for more papers by this authorXulei Tang
The First Hospital of Lanzhou University, Lanzhou, China
Search for more papers by this authorQing Su
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Search for more papers by this authorYoumin Wang
The First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorGuijun Qin
The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Search for more papers by this authorHuacong Deng
The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Search for more papers by this authorXuefeng Yu
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Search for more papers by this authorFeixia Shen
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorLiebin Zhao
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYu Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMin Xu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYuhong Chen
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorJieli Lu
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorLin Lin
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorRui Du
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMeng Dai
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorMian Li
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorTiange Wang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorZhiyun Zhao
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorDi Zhang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorYufang Bi
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authorDonghui Li
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Search for more papers by this authorCorresponding Author
Weiqing Wang
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Correspondence
Weiqing Wang, National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China.
Tel: +86 21 64749885
Fax: +86 21 64749885
Email: [email protected]
Search for more papers by this authorGuang Ning
National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Search for more papers by this authoron behalf of the REACTION Study Group
Search for more papers by this authorAbstract
enBackground
A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the effect of active smoking and smoking cessation on glycemic control in patients with diabetes. The aim of this study was to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients.
Methods
The present was a cross-sectional study of 10 551 men and 15 297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. Risk factors for glycemic control and the association of active smoking with glycemic control were evaluated using logistic regression models. Poor glycemic control was defined as HbA1c ≥7.0%.
Results
Current smokers have an increased risk of poor glycemic control, and the multivariable-adjusted odds ratio (OR) and 95% confidence intervals (CI) of HbA1c ≥7.0% with current smoking were 1.49 (1.35–1.66) in men and 1.56 (1.13–2.15) in women. Further analysis demonstrated a dose-dependent relationship between active smoking and the risk of poor glycemic control in men. Former smokers who quit smoking for <10 years remained at increased risk of poor glycemic control, with the risk leveling off after 10 years of smoking cessation compared with non-smokers, but risk in former smokers was significantly lower than that in current smokers.
Conclusions
Active smoking is a modifiable risk factor for poor glycemic control in Chinese diabetic patients.
Abstract
zh摘要
背景
大量的既往研究表明, 吸烟可能与糖尿病发病独立相关。然而, 关于吸烟及戒烟与糖尿病患者血糖控制的相关性研究较少。本研究旨在探讨吸烟及戒烟与糖尿病患者血糖控制的相关性。
方法
本研究是一项横断面研究, 研究对象是来自REACTION研究(Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study)中的10551名男性糖尿病患者和15297名女性糖尿病患者。使用logistic回归模型评估血糖控制不佳的危险因素以及吸烟与血糖控制的相关性。HbA1c > 7.0%被定义为血糖控制不佳。
结果
当前吸烟者血糖控制不佳的风险增加。校正多元变量后, 在当前吸烟且HbA1c > 7.0%的患者中, 男性血糖控制不佳的风险增加49% [Odds Ratio(OR):1.49,95% 置信区间(CI):1.35-1.66], 女性血糖控制不佳的风险增加56%(OR:1.56,95%CI:1.13-2.15)。进一步的分析表明在男性人群中当前吸烟与血糖控制不佳的风险存在剂量依赖关系。与从不吸烟者相比, 戒烟年限低于10年者血糖控制不佳的风险仍然存在, 但戒烟10年后风险趋于平稳。戒烟者血糖控制不佳的风险显著低于当前吸烟者。
结论
吸烟是中国糖尿病患者血糖控制不佳的一个可改变的危险因素。
Supporting Information
| Filename | Description |
|---|---|
| jdb12625-sup-0001-SupInfo.docxWord 2007 document , 22.3 KB |
Table S1. Lifestyle factors in different smoking conditions in men with diagnosed diabetes. Table S2. Association between current smoking and glycemic control among non-insulin users stratified by treatments. Table S3. Associations between smoking and glycemic control in Chinese men using current smokers as the reference group (REACTION Study, 2011–2012). Table S4. Logistic regression models analyzing associations between smoking and glycemic control among screened and diagnosed diabetic men. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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