Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women
在黑种人、西班牙裔以及亚裔/太平洋岛民绝经后妇女中性激素水平与白细胞端粒长度的关系
Abstract
enBackground
Sex hormones may play important roles in sex-specific biological aging. In the study, we specifically examined associations between circulating sex hormone concentrations and leukocyte telomere length (TL).
Methods
A cross-sectional study was conducted among 1124 Black, 444 Hispanic, and 289 Asian/Pacific Islander women in the Women's Health Initiative Observational Cohort. Estradiol and testosterone concentrations were measured using electrochemiluminescence immunoassays; TL was measured using quantitative polymerase chain reaction.
Results
Women in the study were aged 50–79 years. Estradiol concentrations were not significantly associated with TL in this sample. The associations between total and free testosterone and TL differed by race/ethnicity (Pinteraction = 0.03 and 0.05 for total and free testosterone, respectively). Total and free testosterone concentrations were not associated with TL in Black and Hispanic women, whereas in Asian/Pacific Islander women their concentrations were inversely associated with TL (Ptrend = 0.003 for both). These associations appeared robust in multiple subgroup analyses and multivariable models adjusted for potential confounding factors. In Asian/Pacific Islander women, a doubling of serum free and total testosterone concentrations was associated with a 202-bp shorter TL (95% confidence interval [CI] 51–353 bp) and 203-bp shorter TL (95% CI 50–355 bp), respectively.
Conclusions
Serum estradiol concentrations were not associated with leukocyte TL in this large sample of postmenopausal women. Total and free testosterone concentrations were inversely associated with TL in Asian/Pacific Islander women, but not in Black and Hispanic women, although future studies to replicate our observations are warranted particularly to address potential ethnicity-specific relationships.
摘要
zh背景
性激素可能在性别特异性的生物老龄化中有着重要作用。在这项研究中, 我们专门研究了血液循环中的性激素浓度与白细胞端粒长度(leukocyte telomere length, TL)之间的关系。
方法
在妇女健康倡议队列观察研究(Women’s Health Initiative Observational Cohort)中, 对1124名黑种人、444名西班牙裔以及289名亚裔/太平洋岛民妇女进行了横断面研究。使用电化学发光免疫测定法测量雌二醇与睾酮的浓度;使用定量聚合酶链反应法检测TL。
结果
这项研究纳入的妇女年龄范围为50-79岁。在这个样本中雌二醇浓度与TL之间没有显著的相关性。总睾酮以及游离睾酮与TL之间的关系具有种族与民族特异性(总睾酮以及游离睾酮与TL之间Pinteraction分别为0.03与0.05)。在黑种人以及西班牙裔妇女中, 总睾酮以及游离睾酮浓度与TL之间均无相关性, 然而在亚裔/太平洋岛民妇女中, 这些指标的浓度却与TL呈负相关(两者均Ptrend = 0.003)。这些相关性在多个亚组分析中以及在校正潜在混杂因素后的多变量模型中仍然很明显。在亚裔/太平洋岛民妇女中, 血清游离睾酮以及总睾酮浓度加倍后分别与TL缩短202-bp(95%置信区间[CI]为51-353 bp)以及TL缩短203-bp(95% CI为50-355 bp)相关。
结论
在这个大规模的绝经后妇女样本中, 血清雌二醇浓度与白细胞TL之间没有相关性。在亚裔/太平洋岛民妇女中总睾酮以及游离睾酮浓度与TL之间呈负相关, 但是在黑种人以及西班牙裔妇女中却没有相关性。然而针对我们的观察结果有必要进行进一步的重复研究, 特别是要调查潜在的种族特异性关系。
