Determining ideal offsets of spatially offset Raman spectroscopy for transcutaneous measurements—A Monte Carlo study
Corresponding Author
Keren Chen
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Foshan Graduate School of Innovation, Northeastern University, Foshan, China
Correspondence
Keren Chen and Shuo Chen, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Email: [email protected] and [email protected]
Search for more papers by this authorMengya sun
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Foshan Graduate School of Innovation, Northeastern University, Foshan, China
Search for more papers by this authorCorresponding Author
Shuo Chen
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Northeastern University, Shenyang, China
Correspondence
Keren Chen and Shuo Chen, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Email: [email protected] and [email protected]
Search for more papers by this authorCorresponding Author
Keren Chen
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Foshan Graduate School of Innovation, Northeastern University, Foshan, China
Correspondence
Keren Chen and Shuo Chen, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Email: [email protected] and [email protected]
Search for more papers by this authorMengya sun
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Foshan Graduate School of Innovation, Northeastern University, Foshan, China
Search for more papers by this authorCorresponding Author
Shuo Chen
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China
Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Northeastern University, Shenyang, China
Correspondence
Keren Chen and Shuo Chen, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Email: [email protected] and [email protected]
Search for more papers by this authorKeren Chen and Mengya sun are joint co-first authors.
Abstract
Spatially offset Raman spectroscopy (SORS) is valuable for noninvasive bone assessment but requires a clearer understanding of how offset distances influence detection depth. To address this, our study devised a forward-adjoint Monte Carlo multi-layer (MCML) model to simulate photon paths in SORS, aiming to determine optimal offsets for various tissue types. We examined photon migration at offsets between 0 and 15 mm against layered phantoms of differing thicknesses and compositions to optimize the signal-to-noise ratio for bone layers. The findings highlight that optimal offsets are contingent on tissue characteristics: a metacarpal beneath 2.5 mm of tissue had an ideal offset of 6.7 mm, while a tibia with 5 mm of soft tissue required 10–11 mm. This precise calibration of SORS via MCML modeling promises substantial improvements in bone health diagnostics and potential for expansive medical applications.
CONFLICT OF INTEREST STATEMENT
The authors declare that there are no conflicts of interest related to this publication.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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