Volume 13, Issue 12 e202000299

FULL ARTICLE

Measurement of two-photon properties of indocyanine green in water and human plasma excited at the 1700-nm window

Xiangquan Deng

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Chen He,

Chen He

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Hui Cheng,

Hui Cheng

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Jia Li,

Jia Li

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Yuan Lu,

Corresponding Author

Yuan Lu

[email protected]

Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen, China

Correspondence

Ping Qiu and Ke Wang, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

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Ping Qiu,

Corresponding Author

Ping Qiu

[email protected]

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

Correspondence

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

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Ke Wang,

Corresponding Author

Ke Wang

[email protected]

orcid.org/0000-0002-9445-2168

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

Correspondence

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

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Xiangquan Deng,

Xiangquan Deng

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Chen He,

Chen He

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Hui Cheng,

Hui Cheng

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Jia Li,

Jia Li

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

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Yuan Lu,

Corresponding Author

Yuan Lu

[email protected]

Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen, China

Correspondence

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

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Ping Qiu,

Corresponding Author

Ping Qiu

[email protected]

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

Correspondence

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

Search for more papers by this author

Ke Wang,

Corresponding Author

Ke Wang

[email protected]

orcid.org/0000-0002-9445-2168

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China

Correspondence

Email: [email protected] (P. Q.) and Email: [email protected] (K. W.)

Yuan Lu, Department of Dermatology, The Sixth Hospital of Shenzhen University (Nanshan Hospital), Shenzhen 518052, China.

Email: [email protected]

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First published: 07 October 2020

https://doi.org/10.1002/jbio.202000299

Citations: 6

Funding information: National Natural Science Foundation of China (NSFC), Grant/Award Numbers: 61775143, 61975126, 62075135; (Key) Project of Department of Education of Guangdong Province, Grant/Award Number: 2017KZDXM073; Science and Technology Innovation Commission of Shenzhen, Grant/Award Numbers: JCYJ20190808174819083, JCYJ20190808175201640

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Abstract

Indocyanine green (ICG) is a human compatible dye and is ideal for deep-tissue two-photon fluorescence (2PF) microscopy excited at the 1700-nm window in vivo. However, the two-photon excitation and emission properties of this dye remain unknown. Here we demonstrate measurement of the two-photon excitation and emission properties of ICG in both water and human plasma, using home-built two-photon action cross-sectional measurement and two-photon emission spectrum measurement systems. Our results show that excited from 1600 to 1800 nm, 2PF can be generated from ICG dissolved in both water and human plasma. The measured two-photon action cross-sectional ησ₂ of ICG dissolved in human plasma is an order-of-magnitude larger than that dissolved in water. The measured two-photon emission spectrum overlaps with the one-photon emission spectrum for ICG dissolved in both human plasma and water. Our results will provide key two-photon parameters for the clinical use of ICG.

Open Research

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Volume13, Issue12

December 2020

e202000299

Measurement of two-photon properties of indocyanine green in water and human plasma excited at the 1700-nm window

Abstract

Open Research

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References

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Measurement of two-photon properties of indocyanine green in water and human plasma excited at the 1700-nm window

Abstract

Open Research

DATA AVAILABILITY STATEMENT

REFERENCES

Citing Literature

References

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