Volume 13, Issue 9 e202000040

FULL ARTICLE

Hyperspectral imaging and characterization of allergic contact dermatitis in the short-wave infrared

Tommy Du,

Tommy Du

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Deependra K. Mishra,

Deependra K. Mishra

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Leonid Shmuylovich,

Leonid Shmuylovich

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Andy Yu,

Andy Yu

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Search for more papers by this author

Helena Hurbon,

Helena Hurbon

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Search for more papers by this author

Steven T. Wang,

Steven T. Wang

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

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Mikhail Y. Berezin,

Corresponding Author

Mikhail Y. Berezin

[email protected]

orcid.org/0000-0002-2670-2487

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Correspondence

Mikhail Y. Berezin, Department of Radiology, Washington University School of Medicine, 4515 McKinley Ave, St. Louis, MO 63110.

Email: [email protected]

Search for more papers by this author

Tommy Du,

Tommy Du

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Deependra K. Mishra,

Deependra K. Mishra

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Leonid Shmuylovich,

Leonid Shmuylovich

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri, USA

Tommy Du, Deependra K. Mishra and Leonid Shmuylovich authors contributed equally.Search for more papers by this author

Andy Yu,

Andy Yu

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Search for more papers by this author

Helena Hurbon,

Helena Hurbon

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Search for more papers by this author

Steven T. Wang,

Steven T. Wang

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Search for more papers by this author

Mikhail Y. Berezin,

Corresponding Author

Mikhail Y. Berezin

[email protected]

orcid.org/0000-0002-2670-2487

Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA

Correspondence

Mikhail Y. Berezin, Department of Radiology, Washington University School of Medicine, 4515 McKinley Ave, St. Louis, MO 63110.

Email: [email protected]

Search for more papers by this author

First published: 16 May 2020

https://doi.org/10.1002/jbio.202000040

Citations: 13

Funding information: National Institutes of Health, Grant/Award Numbers: 1S10RR03162, R01 CA208623; National Science Foundation, Grant/Award Numbers: IIA-1355406, PFI-TT 1827656

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Abstract

Short-wave infrared hyperspectral imaging is applied to diagnose and monitor a case of allergic contact dermatitis (ACD) due to poison ivy exposure in one subject. This approach directly demonstrates increased tissue fluid content in ACD lesional skin with a spectral signature that matches the spectral signature of intradermally injected normal saline. The best contrast between the affected and unaffected skin is achieved through a selection of specific wavelengths at 1070, 1340 and 1605 nm and combining them in a pseudo-red-green-blue color space. An image derived from these wavelengths normalized to unaffected skin defines a “tissue fluid index” that may aid in the quantitative diagnosis and monitoring of ACD. Further clinical testing of this promising approach towards disease detection and monitoring with tissue fluid content quantification is warranted.

CONFLICT OF INTEREST

M.B. is the founder of HSpeQ LLC, a hyperspectral imaging software company.

Supporting Information

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Volume13, Issue9

September 2020

e202000040

Hyperspectral imaging and characterization of allergic contact dermatitis in the short-wave infrared

Abstract

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

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Hyperspectral imaging and characterization of allergic contact dermatitis in the short-wave infrared

Abstract

CONFLICT OF INTEREST

Supporting Information

REFERENCES

Citing Literature

References

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