Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography
Jian Zhang
Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
These authors contributed equally to this workSearch for more papers by this authorJing Liu
Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China
These authors contributed equally to this workSearch for more papers by this authorLi-Mei Wang
Center for Drug Non-clinical Evaluation and Research, Guangdong Biological Resources Institute, Guangdong Academy of Sciences, Guangzhou, 510900 China
Search for more papers by this authorZhi-Yuan Li
Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China
Search for more papers by this authorCorresponding Author
Zhen Yuan
- [email protected]
- +853-88224989 | Fax: +853-88222314
Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
Corresponding author: e-mail: [email protected], Phone: +853-88224989, Fax: +853-88222314
** These authors contributed equally to this work.
Search for more papers by this authorJian Zhang
Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
These authors contributed equally to this workSearch for more papers by this authorJing Liu
Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China
These authors contributed equally to this workSearch for more papers by this authorLi-Mei Wang
Center for Drug Non-clinical Evaluation and Research, Guangdong Biological Resources Institute, Guangdong Academy of Sciences, Guangzhou, 510900 China
Search for more papers by this authorZhi-Yuan Li
Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190 China
Search for more papers by this authorCorresponding Author
Zhen Yuan
- [email protected]
- +853-88224989 | Fax: +853-88222314
Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
Corresponding author: e-mail: [email protected], Phone: +853-88224989, Fax: +853-88222314
** These authors contributed equally to this work.
Search for more papers by this authorAbstract
Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal tests were conducted, which validated that Janus microspheres, as a novel type of OCT tracer, were very effective in improving the OCT imaging contrast.
Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver.
Supporting Information
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References
- 1Y. Zhao, H. Tu, Y. Liu, A. J. Bower, and S. A. Boppart, J. Biophotonics 8, 512–521 (2015).
- 2Y. Zhao, Z. Chen, C. Saxer, S. Xiang, J. F. de Boer, and J. S. Nelson, Opt. Lett. 25, 114–116 (2000).
- 3Y. Wang, J. Nelson, Z. Chen, B. Reiser, R. Chuck, and R. Windeler, Opt. Express 11, 1411–1417 (2003).
- 4S. G. Proskurin, Y. He, and R. K. Wang, Opt. Lett. 28, 1227–1229 (2003).
- 5Q. Zhu, D. Piao, M. M. Sadeghi, and A. J. Sinusas, Opt. Lett. 28, 1704–1706 (2003).
- 6Z. Ding, H. Ren, Y. Zhao, J. S. Nelson, and Z. Chen, Opt. Lett. 27, 243–245 (2002).
- 7Y. Jia, S. T. Bailey, T. S. Hwang, S. M. McClintic, S. S. Gao, M. E. Pennesi, C. J. Flaxel, A. K. Lauer, D. J. Wilson, and J. Hornegger, Proc. Natl. Acad. Sci. U.S.A. 112, E2395–E2402 (2015).
- 8H. Wang, U. Baran, and R. K. Wang, J. Biophotonics. 8, 265–272 (2015).
- 9I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, and E. Pomerantsev, J. Am. Coll. Cardiol. 39, 604–609 (2002).
- 10C. H. Liu, Y. Du, M. Singh, C. Wu, Z. Han, J. Li, A. Chang, C. Mohan, and K. V. Larin, J. Biophotonics DOI: 10.1002/jbio.201500269 (2016).
- 11N. Ghosh, M. F. Wood, S. h. Li, R. D. Weisel, B. C. Wilson, R. K. Li, and I. A. Vitkin, J. Biophotonics 2, 145–156 (2009).
- 12B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, Radiology 218, 261–266 (2001).
- 13K. V. Larin, M. S. Eledrisi, M. Motamedi, and R. O. Esenaliev, Diabetes care 25, 2263–2267 (2002).
- 14D. A. Benaron, W. F. Cheong, and D. K. Stevenson, Science 276, 2002–2003 (1997).
- 15U. Morgner, W. Drexler, F. Kärtner, X. Li, C. Pitris, E. Ippen, and J. Fujimoto, Opt. Lett. 25, 111–113 (2000).
- 16A. V. D'Amico, M. Weinstein, X. Li, J. P. Richie, and J. Fujimoto, Urology 55, 783–787 (2000).
- 17T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. J. Toublan, K. S. Suslick, and S. A. Boppart, Opt. Lett. 28, 1546–1548 (2003).
- 18C. Xu, J. Ye, D. L. Marks, and S. A. Boppart, Opt. Lett. 29, 1647–1649 (2004).
- 19H. Cang, T. Sun, Z. Y. Li, J. Chen, B. J. Wiley, Y. Xia, and X. Li, Opt. Lett. 30, 3048–3050 (2005).
- 20C. Yang, L. E. McGuckin, J. D. Simon, M. A. Choma, B. E. Applegate, and J. A. Izatt, Opt. Lett. 29, 2016–2018 (2004).
- 21A. L. Oldenburg, M. N. Hansen, T. S. Ralston, A. Wei, and S. A. Boppart, J. Mater. Chem. 19, 6407–6411 (2009).
- 22K. Jung, B. Park, W. Song, B. HO, and T. Eom, Powder technol. 126, 255–265 (2002).
- 23M. Born and E. Wolf, Principles of Optics (Cambridge University Press, Cambridge, 1999), pp. 54–59 and 628–633.
- 24J. Liu, C. Zhang, Y. Zong, H. Guo, and Z. Y. Li, Photon. Res. 3, 265–274 (2015).
- 25J. Zhang, W. Ge, and Z. Yuan, Biomed. Opt. Express 6, 3932–3940 (2015).
- 26Z. Yuan, Q. Wang, and H. Jiang, Opt. Express 15, 18076–18081 (2007).
- 27Z. Zhang, B. Zhu, and W. Ge, Mol. Endocrinol. 29, 76–98 (2014).
- 28K. Wang and Z. Ding, Chin. Opt. Lett. 6, 902–904 (2008).
- 29D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, J. G. Fujimoto, Science 254, 1178–1181 (1991).
- 30X. Dai, L. Xi, C. Duan, H. Yang, H. Xie, and H. Jiang, Opt. Lett. 40, 2921–2924 (2015).
- 31A. Bykov, T. Hautala, M. Kinnunen, A. Popov, S. Karhula, S. Saarakkala, M. T. Nieminen, V. Tuchin, and I. Meglinski, J. Biophotonics 9, 270–275 (2016).
