Acellular fish skin grafts in the treatment of diabetic wounds: Advantages and clinical translation
Chenyu Zhao
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorMengyi Feng
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorMartin Gluchman
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorXianghe Ma
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorJinhao Li
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Search for more papers by this authorCorresponding Author
Hui Wang
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Correspondence
Hui Wang, Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Email: [email protected]
Search for more papers by this authorChenyu Zhao
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorMengyi Feng
School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, China
Search for more papers by this authorMartin Gluchman
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorXianghe Ma
Department of China Medical University-The Queen's University of Belfast Joint College, School of Pharmacy, China Medical University, Shenyang, China
School of Pharmacy, Queen's University Belfast, Belfast, UK
Search for more papers by this authorJinhao Li
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Search for more papers by this authorCorresponding Author
Hui Wang
Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang, China
Correspondence
Hui Wang, Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.
Email: [email protected]
Search for more papers by this authorAbstract
Diabetic wounds cannot undergo normal wound healing due to changes in the concentration of hyperglycemia in the body and soon evolve into chronic wounds causing amputation or even death of patients. Diabetic wounds directly affect the quality of patients and social medical management; thus researchers started to focus on skin transplantation technology. The acellular fish skin grafts (AFSGs) are derived from wild fish, which avoids the influence of human immune function and the spread of the virus through low-cost decellularization. AFSGs contain a large amount of collagen and omega-3 polyunsaturated fatty acids and they have an amazing effect on wound regeneration. However, after our search in major databases, we found that there were few research trials in this field, and only one was clinically approved. Therefore, we summarized the advantages of AFSGs and listed the problems faced in clinical use. The purpose of this paper is to enable researchers to better carry out original experiments at various stages.
CONFLICT OF INTEREST STATEMENT
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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