• Issue

    Laryngoscope Investigative Otolaryngology: Volume 8, Issue 5

    1131-1435
    October 2023

ISSUE INFORMATION

Open Access

Issue Information

  • Pages: 1131-1135
  • First Published: 26 October 2023

ALLERGY, RHINOLOGY, AND IMMUNOLOGY

ORIGINAL RESEARCH

Open Access

Active anterior rhinomanometry: A study on nasal airway resistance, paradoxical reactions to decongestion, and repeatability in healthy subjects

  • Pages: 1136-1145
  • First Published: 29 September 2023
Active anterior rhinomanometry: A study on nasal airway resistance, paradoxical reactions to decongestion, and repeatability in healthy subjects

This is a study on active anterior rhinomanometry (AAR) where we try to fill some important gaps in knowledge about the method. Hopefully, our manuscript will spark future studies and a more critical use of AAR in Swedish and international clinical practice and research.

Open Access

The relationship between prebiotic intake and allergic rhinitis

  • Pages: 1146-1153
  • First Published: 03 October 2023
The relationship between prebiotic intake and allergic rhinitis

Exploring the relationship between intake of probiotics and the prevalence of allergic rhinitis.

COMPREHENSIVE (GENERAL) OTOLARYNGOLOGY

ORIGINAL RESEARCH

Open Access

A retrospective analysis of COVID-19 tracheostomies: Early versus late tracheostomy

  • Pages: 1154-1158
  • First Published: 16 August 2023
A retrospective analysis of COVID-19 tracheostomies: Early versus late tracheostomy

A retrospective study was performed on all COVID-19 tracheostomies between March 2020 to May 2022 at Ochsner-affiliated hospitals. There was no statistically significant difference in mortality rate, rate of liberation from the ventilator, duration of ventilation, or rate of decannulation.

Open Access

Simulation-based workshop for emergency preparedness in otolaryngology

  • Pages: 1159-1168
  • First Published: 24 August 2023
Simulation-based workshop for emergency preparedness in otolaryngology

This study evaluated the outcomes of a hands-on simulation-based course designed to enhance junior OHNS residents' preparedness in managing otolaryngologic emergencies. The course led to significant reductions in anxiety and increases in confidence among participants, particularly in the areas of foreign body retrieval and airway management which were simulation-based stations; however, confidence decreased and anxiety increased for the lecture-only epistaxis station. The study suggests that simulation-centered training can be effective in improving residents' skills and confidence in critical procedures, benefiting patient safety.

Open Access

Airway management during unusual tracheal stenosis: A clinical feasibility trial

  • Pages: 1169-1177
  • First Published: 02 September 2023
Airway management during unusual tracheal stenosis: A clinical feasibility trial

This study demonstrates the feasibility of using Tritube with FCV in patients with unusual subglottic posterior location tracheal stenosis, undergoing laryngotracheal surgery. Tritube provides a good surgical field and FCV provides highly adequate ventilation, especially in patients with compromised lung mechanics.

Open Access

Gadolinium as a contrast agent for infusion sialograms in patients with iodine allergy

  • Pages: 1178-1183
  • First Published: 18 September 2023
Gadolinium as a contrast agent for infusion sialograms in patients with iodine allergy

We describe the use of a gadolinium-based contrast agent as an alternative agent for digital infusion sialogrpahy in patients with iodine allergies. Our investigation demonstrates gadolinium, compared to iodine-based agents, as an adequate alternative for use in infusion sialography for patients with iodine allergies, supporting the precautionary use of gadolinium as an acceptable contrast agent for the diagnostic and therapeutic benefits in sialography.

FACIAL PLASTICS AND RECONSTRUCTIVE SURGERY

ORIGINAL RESEARCH

Open Access

Predicting synkinesis caused by Bell's palsy or Ramsay Hunt syndrome using machine learning-based logistic regression

  • Pages: 1189-1195
  • First Published: 25 August 2023
Predicting synkinesis caused by Bell's palsy or Ramsay Hunt syndrome using machine learning-based logistic regression

This study compared the accuracy of machine learning (ML) algorithms (logistic regression [LR], random forest, k-nearest neighbor, and gradient-boosting decision tree) to predict facial synkinesis resulting from Bell's palsy or Ramsay Hunt syndrome using early post-onset parameters against conventional statistics-based LR. Results showed that ML-based LR has potential and comparable reliability to predict synkinesis probability. AUCs ranged from 0.711 to 0.910 for the different algorithms and parameters.

Open Access

Modified individualized titanium mesh in orbital floor reconstruction for preventing exposure

  • Pages: 1196-1202
  • First Published: 04 September 2023
Modified individualized titanium mesh in orbital floor reconstruction for preventing exposure

We propose a novel method of zygomatic medial fixation of titanium mesh with a right-angled screwdriver for orbital floor and maxillary reconstruction, which has the potential to prevent the postoperative exposure of titanium mesh.

HEAD AND NECK, AND TUMOR BIOLOGY

ORIGINAL RESEARCH

Open Access

Multidisciplinary care improves outcomes for patients with carotid body paragangliomas—The UCLA experience

  • Pages: 1203-1209
  • First Published: 23 August 2023
Multidisciplinary care improves outcomes for patients with carotid body paragangliomas—The UCLA experience

Carotid body tumors can be managed effectively by single surgical specialties with similar outcomes between vascular surgery and OHNS. In larger, higher grade tumors, however, a combined vascular and OHNS approach had lower incidence of postoperative cranial nerve injuries when compared to single specialty resections, despite a larger EBL.

Open Access

Free-flap volume correlates with body mass index in patients with tongue squamous cell carcinoma

  • Pages: 1210-1216
  • First Published: 16 August 2023
Free-flap volume correlates with body mass index in patients with tongue squamous cell carcinoma

Reconstructed tongue flap volume (RTFV) correlates with body mass index (BMI) in patients with tongue squamous cell carcinoma. In addition, flap type and BMI, but not age or sex, were factors affecting RTFV. Maintaining good nutritional status, with BMI as an indicator, is crucial to avoid loss of RTFV.

REVIEW

Open Access

Survival after induction chemotherapy in locoregional advanced nasopharyngeal carcinoma: An updated systematic review and meta-analysis

  • Pages: 1217-1225
  • First Published: 19 August 2023
Survival after induction chemotherapy in locoregional advanced nasopharyngeal carcinoma: An updated systematic review and meta-analysis

Induction chemotherapy with concurrent chemoradiotherapy is beneficial for nasopharyngeal carcinoma patients from the viewpoint of survival.

ORIGINAL RESEARCH

Open Access

Effectiveness of Sucralfate comparing to normal saline as an oral rinse in pain reduction and wound healing promotion in oral surgery

  • Pages: 1226-1232
  • First Published: 24 August 2023
Effectiveness of Sucralfate comparing to normal saline as an oral rinse in pain reduction and wound healing promotion in oral surgery

Sucralfate suspension oral rinse can be recommended as an effective topical analgesic solution in postoperative secondary healing of intraoral wound with no significant interference. Benefits to wound healing promotion have yet to be proven.

Open Access

Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection

  • Pages: 1233-1239
  • First Published: 31 August 2023
Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection

A 1 mg/L beta trace protein (β-TP) concentration in nasal secretion can be established as a cut-off point for CSF leakage diagnosis with high sensibility and specificity. β-TP analysis could be useful to check CSF leak resolution.

HEALTH POLICY AND OUTCOMES

REVIEW

Open Access

Enhanced recovery after surgery, current, and future considerations in head and neck cancer

  • Pages: 1240-1256
  • First Published: 04 September 2023

Since it's conception, enhanced recovery after surgery (ERAS) protocols have continued to push for comprehensive and evidence based postsurgical care to improve patient outcomes. Head and neck oncology is one of the newest fields to develop a protocol. Due to the complexity of this patient population and their postsurgical needs, a multidisciplinary approach is needed to facilitate recovery while minimizing complications. This article summarizes current and future principles in head and neck ERAS protocols.

EDITORIAL

LARYNGOLOGY, SPEECH AND LANGUAGE SCIENCE

ORIGINAL RESEARCH

Open Access

Self-reported throat symptoms in Ehlers–Danlos syndromes and hypermobility spectrum disorders: A cross-sectional survey study

  • Pages: 1259-1264
  • First Published: 18 September 2023
Self-reported throat symptoms in Ehlers–Danlos syndromes and hypermobility spectrum disorders: A cross-sectional survey study

A survey study into throat symptoms of Ehlers–Danlos syndromes and hypermobility spectrum disorders found that participants experience symptoms of acid reflux, swallowing problems and voice problems to varying degrees of severity.

Open Access

Clinician accuracy in identifying essential laryngeal landmarks on swallowing fluoroscopy

  • Pages: 1265-1271
  • First Published: 29 July 2023
Clinician accuracy in identifying essential laryngeal landmarks on swallowing fluoroscopy

The study investigated the accuracy of clinicians and trainees in identifying essential laryngeal landmarks on videofluoroscopic swallow studies (VFSS). A single human cadaver was used to verify the location of laryngeal structures under fluoroscopy, and participants were asked to identify 18 structures on unmarked fluoroscopic images. The results showed that overall accuracy was low, with an average rate of correct identification at less than 50%, and there were no significant differences in accuracy between clinicians and trainees or between speech-language pathologists and physicians. The study suggests that more training is needed to improve clinicians' ability to identify essential anatomical structures on VFSS.

Open Access

Late laryngeal dysfunction in head and neck cancer survivors

  • Pages: 1272-1278
  • First Published: 31 July 2023
Late laryngeal dysfunction in head and neck cancer survivors

We describe laryngeal dysfunction in a cohort of long-term HNC survivors. This sequelae of long-term damage to the larynx included swallowing dysfunction, voice change, chronic cough, vocal fold motion abnormalities and mucosal changes. There was a weak correlation between time since treatment and laryngeal dysfunction, and overall, late laryngeal dysfunction in this population contributes to significant morbidity and is difficult to treat.

Open Access

Voice outcomes in high-grade Reinke's edema: Comparing microflap excision and microdebrider surgery

  • Pages: 1279-1287
  • First Published: 19 August 2023
Voice outcomes in high-grade Reinke's edema: Comparing microflap excision and microdebrider surgery

We compared patient outcomes in patients who had microflap or microdebrider excision surgeries for Reinke's edema (RE). Both microflap excision and microdebrider excision for high-grade RE lesions resulted in significant improvement in Voice Handicap Index-30, Voice-Related Quality Of Life, and mean phonation time at 1-month and 6-months postoperatively with the microdebrider excision group scoring statistically significantly better at 6-months in comparison to the microflap group. Overall, the results support the use of both surgical modalities for treating high-grade RE patients.

Open Access

Somatic anxiety in patients with laryngopharyngeal reflux

  • Pages: 1288-1293
  • First Published: 16 August 2023
Somatic anxiety in patients with laryngopharyngeal reflux

Patients with laryngopharyngeal reflux (LPR) had more severe somatic anxiety than healthy individuals. Somatic anxiety symptoms were more frequent than subjective anxiety symptoms in patients with laryngopharyngeal reflux (LPR). The somatic anxiety symptoms were correlated with LPR-related symptoms in patients with LPR. The somatic anxiety symptoms such as trembling hands, shaky, difficulty in breathing, and faint symptoms were statistically associated with LPR. Those somatic anxiety symptoms may represent physiological arousal of patients with LPR.

Open Access

Computational fluid dynamics of upper airway aerodynamics for exercise-induced laryngeal obstruction: A feasibility study

  • Pages: 1294-1303
  • First Published: 19 August 2023
Computational fluid dynamics of upper airway aerodynamics for exercise-induced laryngeal obstruction: A feasibility study

This paper describes the use of computational fluid dynamic modeling to evaluate changes in upper airway geometry and aerodynamics during an exercise-induced laryngospasm event and selection of best rescue breathing strategy for patients with exercise-induced laryngospasm.

Open Access

Platelet-rich plasma in treatment of scar, atrophy, and sulcus: Short- and long-term results

  • Pages: 1304-1311
  • First Published: 05 September 2023
Platelet-rich plasma in treatment of scar, atrophy, and sulcus: Short- and long-term results

This is a report on the short and long term voice outcomes after Platelet Rich Plasma injection into the vocal folds. It shows both short and long term benefits in subjective and objective measures. The mild and moderate dysphonia patients had more benefit than the severely dysphonic patients.

Open Access

End-to-end deep learning classification of vocal pathology using stacked vowels

  • Pages: 1312-1318
  • First Published: 31 August 2023
End-to-end deep learning classification of vocal pathology using stacked vowels

Artificial intelligence (AI) analysis of multiple vowel recordings can improve classification of voice pathologies compared with models using a single sustained vowel and offer a strategy to enhance AI-driven screening of voice disorders.

Open Access

Assessment of vocal fold movement through anterior–posterior view of videofluoroscopic swallowing study

  • Pages: 1319-1323
  • First Published: 07 September 2023
Assessment of vocal fold movement through anterior–posterior view of videofluoroscopic swallowing study

The study evaluated the value of using videofluoroscopic swallowing study for vocal fold paralysis. High positive predictive value, inter and intra-rater reliability showed that videofluoroscopic swallowing study can be used to screen and assess vocal fold paralysis.

Open Access

Risk factors for postoperative vocal fold fibrosis following microlaryngeal surgery

  • Pages: 1324-1327
  • First Published: 13 September 2023
Risk factors for postoperative vocal fold fibrosis following microlaryngeal surgery

This study discovered that fibrous masses, lesion attachment to the vocal ligament and prolonged symptom duration are significant risk factors for postoperative vocal fold fibrosis.

Open Access

Extended partial laryngectomy with functional preservation using the rotational crico-thyrotracheopexy

  • Pages: 1328-1336
  • First Published: 19 September 2023
Extended partial laryngectomy with functional preservation using the rotational crico-thyrotracheopexy

The study evaluated the effectiveness of rotational crico-thyrotracheopexy as a functional reconstruction technique for the laryngeal framework in patients with advanced unilateral glottic tumors after extended vertical hemilaryngectomy.

OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE

ORIGINAL RESEARCH

Open Access

Binocular microscopes versus exoscopes: Experiences and performance in simulated otologic surgery

  • Pages: 1337-1344
  • First Published: 03 August 2023
Binocular microscopes versus exoscopes: Experiences and performance in simulated otologic surgery

Our study prospectively compares the exoscope to the traditional binocular operative microscope (OM). We tested 29 participants, 14 medical students and 15 residents. Overall performance, predefined errors and time to task completion, was better with the OM. Subjectively, on effort required and ease of use the two systems were rated similarly by participants.

ORIGINAL RESEARCH

Open Access

Gathering validity evidence for a 3D-printed simulator for training of myringotomy and ventilation tube insertion

  • Pages: 1357-1364
  • First Published: 16 August 2023
Gathering validity evidence for a 3D-printed simulator for training of myringotomy and ventilation tube insertion

This study aimed to gather validity evidence of a 3D-printed simulator for ventilation tube insertion training of ENT residents. The study included 15 residents and 13 experts. We established solid educational validity evidence and established a reliable pass/fail standard.

Open Access

Association between depression and tinnitus in US adults: A nationally representative sample

  • Pages: 1365-1375
  • First Published: 21 August 2023
Association between depression and tinnitus in US adults: A nationally representative sample

This study used data from the NHANES to examine the link between tinnitus and depression among US adults. It found that tinnitus was associated with a higher risk of depression, even after adjusting for other factors. The study suggested that psychological factors should be considered in the treatment of tinnitus.

REVIEW

Open Access

Bell's palsy in pregnancy: A scoping review of risk factors, treatment and outcomes

  • Pages: 1376-1383
  • First Published: 14 August 2023
Bell's palsy in pregnancy: A scoping review of risk factors, treatment and outcomes

We report a scoping review of all available evidence on the risk factors, treatment and facial function outcomes of pregnant women with Bell's palsy.

ORIGINAL RESEARCH

Open Access

Tinnitus characteristics in patients with idiopathic sudden sensorineural hearing loss and acute tinnitus

  • Pages: 1384-1389
  • First Published: 11 August 2023
Tinnitus characteristics in patients with idiopathic sudden sensorineural hearing loss and acute tinnitus

The recovery of acute tinnitus was not correlated with the loudness and pitch of tinnitus in patients with idiopathic sudden sensorineural hearing loss. The improvement in acute tinnitus was significantly greater in patients who had complete recovery of hearing.

Open Access

Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation

  • Pages: 1390-1400
  • First Published: 07 September 2023
Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation

We assessed the effects of electrical stimulation of cochlear implant on postimplantation inflammation and fibrosis. We observed that electrical stimulation of cochlear implant promoted the activation of macrophages and fibroblasts under inflammation. This suggests that the cochlear implant needs to be activated after the acute inflammation has subsided and the subsequent electrical stimulation process is also needed to suppress chronic inflammation and fibrosis.

Open Access

Unimodal versus bimodal auditory stimulation in inner ear malformations: Cognitive, language, and motor performance

  • Pages: 1401-1409
  • First Published: 18 September 2023
Unimodal versus bimodal auditory stimulation in inner ear malformations: Cognitive, language, and motor performance

This study investigated the cognitive, language, and motor skills of auditory brainstem implant users in unimodal and bimodal groups. Although there were no significant differences between bimodal and unimodal groups, a holistic approach should be used in the assessment process.

Open Access

Electrophysiological and molecular changes following neuroprotective placental protein administration on tinnitus-induced rats

  • Pages: 1410-1420
  • First Published: 03 October 2023
Electrophysiological and molecular changes following neuroprotective placental protein administration on tinnitus-induced rats

This study evaluated the effect of a novel neuroprotective protein compound (NPPC) on electrophysiological and molecular changes in the medial geniculate body (MGB) of tinnitus-induced rats. The results showed NPPC can play an effective role in the treatment of tinnitus.

PEDIATRICS AND DEVELOPMENT

ORIGINAL RESEARCH

Open Access

Interarytenoid injection outcomes in pediatric feeding disorders

  • Pages: 1421-1427
  • First Published: 16 August 2023
Interarytenoid injection outcomes in pediatric feeding disorders

Our data suggest that Prolaryn IIA is a safe and effective treatment option for oropharyngeal dysphagia in children. Furthermore, IIA was effective in those diagnosed with a DIG, an anatomic abnormality that has not been thoroughly studied and, therefore, lacks management guidelines.

Open Access

Establishment of novel immortalized middle ear cell lines as models for otitis media

  • Pages: 1428-1435
  • First Published: 28 August 2023
Establishment of novel immortalized middle ear cell lines as models for otitis media

Otitis media (OM) is a common condition in children and poses a significant public health burden, but only a single immortalized human middle ear epithelial (MEE) cell line exists for its study. We generated and characterized five new middle ear cell lines from pediatric patients with non-inflamed MEE, recurrent OM, or OM with effusion and demonstrated differences in their baseline inflammatory cytokine expression and response to stimulation with an OM-relevant pathogen and cytokines. Immortalized MEE lines retained the cytokine expression and responsiveness of their tissues of origin and differences between non-OM versus OM and pediatric versus adult cultures, supporting their value as novel in vitro culture models for OM.