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ISSUE INFORMATION
ALLERGY, RHINOLOGY, AND IMMUNOLOGY
ORIGINAL RESEARCH
On the in vivo origin of human nasal mesenchymal stem cell cultures
- Pages: 975-982
- First Published: 10 October 2020
Evaluation of predictive value of olfactory dysfunction, as a screening tool for COVID-19
- Pages: 983-991
- First Published: 22 October 2020
REVIEW
Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis
- Pages: 992-1002
- First Published: 28 October 2020
ORIGINAL RESEARCH
A multicenter survey on the effectiveness of nasal irrigation devices in rhinosinusitis patients
- Pages: 1003-1010
- First Published: 16 November 2020
Radioanatomical study of the extended free nasal floor mucosal graft and its clinical applications
- Pages: 1011-1018
- First Published: 18 November 2020
Olfactory and taste dysfunction among mild-to-moderate symptomatic COVID-19 positive health care workers: An international survey
- Pages: 1019-1028
- First Published: 02 December 2020
FACIAL PLASTICS AND RECONSTRUCTIVE SURGERY
REVIEW
Vascular pedicled flaps for skull base defect reconstruction
- Pages: 1029-1038
- First Published: 15 October 2020

Endoscopic reconstruction of skull base defects has rapidly advanced since the introduction of the nasoseptal flap in 2006. Here, we review current techniques of vascular pedicled flap reconstruction of skull base defects, their indications and success rates, and novel techniques currently under investigation.
ORIGINAL RESEARCH
Review of literature of saddle nose deformity reconstruction and presentation of vomer onlay graft
- Pages: 1039-1043
- First Published: 16 October 2020

Vomerian bone onlay grafts are a reconstructive option for saddle nose deformity and nasal dorsum defects. While septal cartilage is commonly used, and ethmoidal bone has been previously described as an option for composite graft reconstruction, vomer bone onlay grafting has not been well described in the literature. The aesthetic outcomes following nasal dorsum reconstruction using onlay grafts are favorable, but long-term outcomes of these grafts require further study.
Change in surgeon for revision rhinoplasty: The impact of patient demographics and surgical technique on patient retention
- Pages: 1044-1049
- First Published: 12 November 2020
COMPREHENSIVE (GENERAL) OTOLARYNGOLOGY
ORIGINAL RESEARCH
Effect of respiratory muscle training on dysphagia in stroke patients—A retrospective pilot study
- Pages: 1050-1055
- First Published: 23 October 2020
Dysphagia is prevalent with cerebrovascular accidents and is often associated with respiratory muscle weakness. This retrospective pilot study investigates the effectiveness of respiratory muscle training to improve swallow function and safety, and found combined respiratory muscle training to be a feasible and effective method to improve signs and symptoms of dysphagia while improving airway protection.
Risk factors of post-tonsillectomy hemorrhage in adults
- Pages: 1056-1062
- First Published: 14 November 2020
HEAD AND NECK, AND TUMOR BIOLOGY
ORIGINAL RESEARCH
Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck
- Pages: 1063-1069
- First Published: 27 October 2020
Circulating tumors cells (CTCs) were detected in 6/25 patients with locoregionally advanced disease (24%) and 4/11 with metastatic squamous cell carcinoma of the head and neck (36%). On univariate analysis, smoking was associated with CTCs.
The prognostic significance of human papilloma virus in sinonasal squamous cell carcinoma
- Pages: 1070-1078
- First Published: 04 November 2020
REVIEW
The role of vitamin D in head and neck cancer
- Pages: 1079-1088
- First Published: 03 November 2020
Migraine and risk of sudden sensorineural hearing loss: A systematic review and meta-analysis
- Pages: 1089-1095
- First Published: 20 October 2020
ORIGINAL RESEARCH
Single-surgeon parotidectomy outcomes in an academic center experience during a 15-year period
- Pages: 1096-1103
- First Published: 21 October 2020
Subjective functional outcomes in oropharyngeal cancer treated with induction chemotherapy using the MD Anderson Symptom Inventory (MDASI)
- Pages: 1104-1109
- First Published: 06 November 2020
HPV-positive oropharyngeal cancer typically has a good survival prognosis. Standard treatment with radiation and chemotherapy, while curative, can produce long term dysfunctional outcomes. Induction chemotherapy has not been shown to improve overall survival but is occasionally used in patients with high stage and/or aggressive disease. we looked at the impact of induction chemotherapy on subjective functional outcomes.
LARYNGOLOGY, SPEECH AND LANGUAGE SCIENCE
ORIGINAL RESEARCH
Laryngeal fractures in professional and semiprofessional ice hockey players
- Pages: 1110-1116
- First Published: 16 October 2020
Laryngeal complications of COVID-19
- Pages: 1117-1124
- First Published: 30 October 2020
A longitudinal study of the Swedish MD Anderson Dysphagia Inventory in patients with oral cancer
- Pages: 1125-1132
- First Published: 03 November 2020
Reliability of peak expiratory flow percentage compared to endoscopic grading in subglottic stenosis
- Pages: 1133-1139
- First Published: 07 November 2020
OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE
ORIGINAL RESEARCH
Impact of occlusive material and cochlea-carotid artery relation on eustachian tube occlusion in subtotal petrosectomy
- Pages: 1140-1146
- First Published: 21 October 2020

The present study evaluates the success rate of eutachian tube occlusion in subtotal petrosectomy using two different occlusion materials. Additionally, it explores whether there is an anatomic topographic predisposition for insufficient eustachian tube occlusion with the intention to weigh benefit against potential risk of this surgical step.
REVIEW
Does cannabis alleviate tinnitus? A review of the current literature
- Pages: 1147-1155
- First Published: 30 October 2020

The aim of this review article is to evaluate the scope and findings of existing literature on the relationship between cannabis and cannabinoid pathways and tinnitus. While animal studies have revealed that cannabinoid receptors likely have a role in modulating auditory signaling, there is no compelling data either from animal or human studies for the use of cannabinoids to alleviate tinnitus.
ORIGINAL RESEARCH
Real-time feedback control of voice in cochlear implant recipients
- Pages: 1156-1162
- First Published: 21 November 2020

The effects of cochlear implants on the vocal and speech production have not been well studied. Using pitch-shifted auditory feedback during vocal production, we show that cochlear implant subjects are capable of real-time feedback-dependent vocal control, but exhibit higher variability and thresholds than expected for normal hearing individuals.
Cochlear implantation in postirradiated ears: A case-control comparative study
- Pages: 1163-1167
- First Published: 28 October 2020
Enhanced fallopian canal as a potential marker for temporal bone vasculitis
- Pages: 1168-1175
- First Published: 04 November 2020

In patients with antineutrophil cytoplasmic antibody-associated vasculitis, contrast-enhanced, 3D-MRI with a gradient-echo sequence showed intense enhancement in the tympanic and mastoid segments of the fallopian canal (C), which was associated with development of external otitis, otitis media, and sensorineural hearing loss, and was unrelated to the presence of facial paresis. The enhancement was attenuated in remission (D). The method can be a potential marker to demonstrate vasculitis status in the temporal bone.
REVIEW
A surgeon-scientist's perspective and review of cognitive-linguistic contributions to adult cochlear implant outcomes
- Pages: 1176-1183
- First Published: 06 November 2020

Enormous variability in speech recognition outcomes persists in adults who receive cochlear implants (CIs), which leads to a barrier to progress in predicting outcomes before surgery, explaining “poor” outcomes, and determining how to provide tailored rehabilitation therapy for individual CI users. The primary goal of my research program over the past nine years has been to extend our understanding of the contributions of “top-down” cognitive-linguistic skills to CI outcomes in adults, acknowledging that “bottom-up” sensory processes also contribute substantially. The main objective of this invited narrative review is to provide an overview of this work, and a secondary objective is to provide career “guidance points” to budding surgeon-scientists in Otolaryngology.
Implantable Hearing Aids: Where are we in 2020?
- Pages: 1184-1191
- First Published: 06 November 2020
Otologic dysfunction in patients with COVID-19: A systematic review
- Pages: 1192-1196
- First Published: 17 November 2020

Otological dysfunction in patients with the novel SARS-CoV-2.There is early evidence to indicate that there is spread of the novel virus into the middle ear and related neural structures resulting in hearing damage. It is of utmost importance to appreciate the rare presentations of SARS-CoV-2 in ENT patients not only to facilitate the diagnosis of COVID-19 but also to help protect and decrease the exposure of the ENT surgeon.
Tinnitus and cognition: Can load theory help us refine our understanding?
- Pages: 1197-1204
- First Published: 16 November 2020
Otitis media with effusion in Africa-prevalence and associated factors: A systematic review and meta-analysis
- Pages: 1205-1216
- First Published: 17 November 2020

The objective of this review was to estimate the overall and subgroup prevalence of otitis media with effusion (OME) in Africa, and identify setting-specific predictors in children and adults. Overall, 38 studies were included, with 27 in meta-analysis (40,331 participants). The overall prevalence was 6%, we recommend health care providers to consider age, presence of cleft palate, adenoid hypertrophy and allergic rhinitis when assessing OME in children and deciding on a management plan.
Autoimmune inner ear disease: A systematic review of management
- Pages: 1217-1226
- First Published: 28 November 2020

Autoimmune inner ear disease is an uncommon inner ear disorder characterized by progressive and often fluctuating sensorineural hearing loss. Currently, there are no consensus treatment recommendations for management of AIED. In this systematic review, we review published treatment paradigms, and create a novel treatment protocol based on existing evidence.
PEDIATRICS AND DEVELOPMENT
ORIGINAL RESEARCH
Patient factors associated with NPO violations in a tertiary care pediatric otolaryngology practice
- Pages: 1227-1232
- First Published: 21 October 2020

NPO violations occurred most commonly among otolaryngology patients when compared to other surgical services. Most children committing NPO violations were between 0 and 6 years of age. A disproportionate number of children from Spanish speaking homes, and who had Medicaid insurance, had NPO violations suggestive of a gap in communication to these patients. Means to bridge these gaps are needed to improve satisfaction and efficiency of the operative experience for all involved.
SLEEP MEDICINE AND SCIENCE
ORIGINAL RESEARCH
Does nasal surgery improve multilevel surgical outcome in obstructive sleep apnea: A multicenter study on 735 patients
- Pages: 1233-1239
- First Published: 08 October 2020
Hyoid expansion with titanium plate and screws with hyomandibular suspension: A study on human cadavers with computed tomographic comparative analysis
- Pages: 1240-1246
- First Published: 21 October 2020

Obstructive sleep apnoea is characterized by repetitive obstruction of the upper airway during sleep. Airway collapse is usually multilevel and hypopharyngeal collapse is a challenging area to address. It is hypothesized that hyoid expansion with hyomandibular suspension can potentially increase upper airway dimensions at the hypopharynx. This study aims to document the effect of hyoid expansion using titanium plate and screws with hyomandibular suspension on hypopharyngeal airway dimensions using human cadaver heads.
THYROID, PARATHYROID, AND ENDOCRINE
ORIGINAL RESEARCH
Non-adherence to consensus guidelines on preoperative imaging in surgery for primary hyperparathyroidism
- Pages: 1247-1253
- First Published: 08 October 2020

This study found that the level of compliance to consensus guidelines on preoperative imaging in patients with primary hyperparathyroidism in routine daily practice was suboptimal (69% adherence). Patients in whom adherence was achieved showed a shorter duration of hospitalization, and if imaging upscaling was performed aiming for positive concordance of anatomical and functional localization, adherence was associated with the performance of a minimally invasive parathyroidectomy. Based on these results, we suggest more education of physicians is required regarding the appropriate preoperative imaging workup in primary hyperparathyroidism leading ultimately to an increased appropriate adherence to consensus guidelines.
Hürthle cell neoplasms of the thyroid: Pathologic outcomes and ultrasonographic analysis
- Pages: 1254-1259
- First Published: 07 October 2020

A retrospective review of 166 patients who had thyroid nodules suspicious for Hurthle cell neoplasm on FNA and underwent hemi- or complete thyroidectomy found that 15.1% of patients had thyroid malignancy. Subgroup analysis suggested that older males and larger nodules are associated with malignancy. TI-RADS grading was not found to predict malignancy in this cohort.
A shift to more targeted thyroidectomies increased the detection of thyroid cancer and in particular low-risk papillary tumors in Southwestern Greece the decade 2007 to 2016
- Pages: 1260-1265
- First Published: 24 November 2020