Human leukocyte antigen-G (HLA-G)14-bp insertion (I)/deletion (D) and+3142 C/G polymorphisms are associated with gynecological cancer (GC) and human papillomavirus-associated cervical cancer. Soluble HLA-G is significantly increased in GC.

Chromodomain helicase DNA binding protein 4 (CHD4) is an ATPase subunit of the nucleosome remodeling and deacetylation complex. It has been implicated in gene transcription, DNA damage repair, maintenance of genome stability, and chromatin assembly. Recently, some researchers have explored the CHD4 functions on the development and differentiation of adaptive immune cells, such as T and B lymphocytes. In this review, we will discuss the details of CHD4 in lymphocyte differentiation and development, as well as the critical role of CHD4 in the pathogenesis of the autoimmune disease.

Aberrations of MAM integrity are considered as a cornerstone in the pathogenesis of several inflammation-mediated metabolic diseases neurodegenerative diseases, CVD, and cancer.

Differences in the anatomical distribution of skin cancer by sex suggest different risk factors between sexes. The rural dwelling was a newly found association with skin cancer and warrants further investigation.

Trends of adverse events and mortality after biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: interrupted time-series analysis.

SARS-COV-2-induced cardiovascular pathology could be through indirectly damaging cardiomyocytes.

Parvez et al. investigate genomic sequences and drug efficacy via a bioinformatic approach with the SARS-CoV-2 Omicron variant. At first, they perform a comparative analysis of Omicron variant with other variants, and then they evaluate the binding affinity with human receptors, ACE2, NRP1, BSG and DPP4. Finally, they analyze the drug effectiveness against the Omicron targeting Main Protease, and found that Nirmatrelvir (Paxlovid), 13b, and Lopinavir displayed increased effectiveness and efficiency

In this serosurveillance study, we observed a high vaccination and low infection rate during the delta surge in a police cohort. Anti-Spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150–200 days after the second vaccine dose.

TRPM7 is negatively regulated by KLF2 transcription and promotes lipopolysaccharide-induced inflammatory dysfunction via activating the MAPK pathway in renal tubular epithelial cells. This article lays the necessary theoretical basis for the prevention and treatment of sepsis-associated acute kidney injury.

We believe that our study makes a significant contribution to the literature because we identify that inducible nitric oxide synthase-deficient may contribute to concanavalin A-induced inflammation by promoting the activation of proinflammatory macrophages.

Here we show that CD200 is reduced in uninvolved psoriasis skin. Its receptor, CD200R1, suppresses neutrophil recruitment to skin, therefore the dysreguation of this pathway in psoriasis may promote immune responses therefore contributing to disease.

A new approach, the moving excess-deficit mortality model, and its method, the weeks of life lost to measure the mortality burden of COVID-19 in the United States.

In this study, we assessed the effect of prostaglandin E2 (PGE2) on the phagocytosis of bacteria by neutrophils, which are key players during infection and inflammation. Specific inhibition of phosphatase and tensin homolog (PTEN) enzyme attenuated the inhibition of neutrophil phagocytosis by PGE2, and both PGE2 and increased intracellular cyclic adenosine monophosphate (cAMP) increased neutrophil PTEN activity, which was associated with decreased PTEN phosphorylation. The results support negative regulation of the antimicrobial activity of neutrophils (i.e., phagocytosis), which has important implications for the future management of bacterial infections.

LINC00638 is down-expressed in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Overexpression of LINC00638 can inhibit cell proliferation and migration, on the contrary, knockdown of LINC00638 can promote cell proliferation and migration.

The HLA-B*15:01 group has a higher rate of EBV infection than other genotype subgroups, B*15:01 is more likely to have non-B-cell infections, and the predominant type of EBV-infected lymphocytes in patients with the B*15:01 genotype should be examined. These findings highlight the importance of HLA genotype for EBV infectivity and that HLA genotype may be used as a marker for some important risk classification

Herpes simplex virus-type 1 (HSV-1) causes significant human diseases, especially in neonates and immunocompromised hosts. Thus, developing novel anti-HSV-1 drugs with low toxicity is necessary for public health. Triptolide (TP) is a diterpenoid triepoxide that, as a natural product, exhibits a broad range of bioactivities. TP also showed antiviral activity against HSV-1. This dose-dependent activity might indicate that a particular cellular component, rather than cytotoxicity, mediated its function. In conclusion, this report proposed new outlooks in investigating the effective treatment options for HSV-1 infections

Risk factors for discontinuing oral immunotherapy.

We revealed the MACROD2 rs6110695 AG genotype has an association with increasing white blood cell (WBC) count, which is one of the risk factors for chronic disease in a Korean population. WBC count measurement in individuals with the rs6110695 AG genotype may help manage the future risk of developing chronic disease.

The immunophenotype of the infections in the vaccinated asymptomatic patients is less inflammatory, accompanied by a modest antibody response. This information will help to understand the immune status of asymptomatic postvaccination infections.

The median latent period of SARS-CoV-2 Delta variant of concern (VOC) infection was 6.0 days. No significant difference of the latent period between vaccinated and non-vaccinated patients was found. Our study support that the 14-day quarantine program is sufficient to prevent the transmission of COVID-19 by Delta VOC in the postvaccination era.