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ISSUE INFORMATION
REVIEW
Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy
- First Published: 18 June 2025
RESEARCH ARTICLE
Advancing Tumor Budding Detection With Fourier Ptychography Microscopy
- First Published: 18 June 2025
Place of Death of People With Cancer in 12 Latin American Countries: A Population Study Using National Death Registers
- First Published: 18 June 2025
Long-Term Trends and Projections of Multiple Myeloma Across Three Continents: A Comparative Study of China, the United States of America, the Russian Federation, England and France (1990–2036)
- First Published: 18 June 2025
ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL
- First Published: 23 June 2025
REVIEW
The Impact and Safety of GLP-1 Agents and Breast Cancer
- First Published: 24 June 2025

Weight gain is a common side effect of breast cancer treatment and is associated with increased cancer progression and mortality. GLP-1 receptor agonists are emerging as potential weight loss therapies for patients with breast cancer. There are key questions central to this paper: Are GLP-1 agents safe? Do they promote weight loss, and do they improve breast cancer outcomes?.
RESEARCH ARTICLE
PDGF-D Promotes Epithelial–Mesenchymal Transition of Glioma Cells Through the NF-κB/NOTCH1 Pathway
- First Published: 18 June 2025
MicroRNA Let-7b-5p Targets IGF1R to Inhibit the Progression of Hepatocellular Carcinoma Through the AKT/mTOR Pathway
- First Published: 18 June 2025

Our study highlights the innovative discovery that miRNAlet-7b-5p targets the IGF1R and inhibits the AKT/mTOR pathway, which has significant implications in the development of novel therapies to combat HCC, including qRT-PCR, clone formation assays, EdU experiments, scratch healing experiments, Transwell experiments, PI experiments, and protein immunoblotting.
An Approach for Differential Diagnosis of Breast Tumors by ctDNA Methylation Sequencing
- First Published: 20 June 2025
Impeding Quorum Sensing Among the Intestinal Microbiota Impacts the Metastatic Rate of Colorectal Cancer
- First Published: 19 June 2025
RPL35A Downregulation Suppresses Hepatocellular Carcinoma Cell Proliferation via NCAPG2 Inactivation
- First Published: 24 June 2025