The cover image is based on the Research Article Exosome-related lncRNA score: A value-based individual treatment strategy for predicting the response to immunotherapy in clear cell renal cell carcinoma by Zhan Yang et al., https://doi.org/10.1002/cam4.7308.

Exosome-related lncRNAs potentially involved in ccRCC pathogenesis with distinctive prognosis and management strategy. Based on four key lncRNAs (EMX2OS, AC026401.3, AL161835.1, and AC018690.1), we constructed an exosome-related lncRNAs score to evaluate its independent prognostic value for ccRCC patients. As the most important ERLR among the four key ERLRs, EMX2OS was screened through mechanical learning and clinical validation, and act as a ceRNA to mediate its downstream network. To further analyze immune and drug sensitivity responses to ccRCC, we finally focus on the effect of EMX2OS on hsa-miR-31-5p/TLN2 axis. ERLR: exosome-related lncRNA; GG: Golgi apparatus; MVB: multivesicular body; ICI: immune checkpoint inhibitors; ccRCC: clear cell renal cell carcinoma.

A prospective randomized controlled trial was performed to evaluate the efficacy of S-1 plus oxaliplatin (SOX) and capecitabine plus oxaliplatin (CAPOX) regimens for patients with advanced gastric cancer (GC) who underwent laparoscopic D2 radical gastrectomy. In the subgroup analysis, the group of patients with male sex, age >60 years, tumors in the gastric antrum, and moderately differentiated tumors showed significantly better overall survival for the SOX regimen.

This study investigates the interval between the primary diagnosis and the development of brain metastases in lung and breast cancer patients, highlighting risk factors associated with shorter intervals. Employing retrospective analysis of patient data, the study identifies clinical, molecular, and therapeutic predictors that could inform early intervention strategies to potentially enhance clinical outcomes in high-risk patients.

This is the first cohort study with the largest number of early-stage pulmonary carcinoids (PCs) to focus on the comparison of outcomes between observation and surgical resection in patients with early-stage PC tumors ≤3 cm in size without lymph node or distant metastasis. After propensity score matching, patients in the observation group had comparable lung carcinoid-specific survival to those in the surgery group for PCs with tumor diameters ≤1 cm, which indicated that observation may be considered in patients with high risk for surgical resection for early PCs ≤1 cm in diameter.

In multiple myeloma (MM)-associated macrophages, miR-34a is overexpressed leading to the downregulation of TLR9 signaling, which suppresses the inflammatory response and impairs the effectiveness of CAR-T cells in tumor eradication.

Towards the end of life, cancer patients use unplanned healthcare which can be potentially preventable. This paper shows that as patients' condition deteriorate, caregivers play an important role in reducing unplanned healthcare use and costs, thus also potentially contributing to reducing the economic burden of cancer.

Rewired KEGG pathway cross-talk network from the normal to the CRC state and their association with cancer hallmarks.

Patient-centric treatment of metastatic renal cell carcinoma (mRCC) requires understanding the treatment expectations and concerns of patients and their physicians. In this cross-sectional study, we analyzed web surveys from 83 mRCC patients and 165 treating physicians and found significant discrepancies in their treatment perspectives. This study highlights that improvements in communication between mRCC patients and their physicians are needed to achieve appropriate patient-centric care.

This paper highlights the limitations and often misinterpretation of drug screening using cell lines derived from gastrointestinal cancers. We show how significant differences in toxicity response is seen when using two dimensional (2D) cell growth versus three dimensional (3D) tumor spheroids.

TFF1 inhibits EMT and stemness in pancreatic cancer and the chemosensitivity of the tumor can be increased by injected TFF1. Combined therapy with TFF1 and traditional chemotherapy could be useful in pancreatic cancer treatment.

TRIM8 degraded VDAC2 through the ubiquitination pathway, increased the resistance of ovarian cancer cells to iron death, and promoted the proliferation and migration of ovarian cancer. This study is the initial demonstration of the cancer-promoting effects of TRIM8 in ovarian cancer by means of a distinct mechanism that involves the regulation of VDAC2.