Preoperative denosumab treatment did not result in an increased risk of local recurrence of GCTB. Patients with advanced GCTB may benefit from preoperative denosumab treatment for surgical downgrading and the preservation of the joint.

Assessment of the effectiveness of avelumab in a diverse group of patients with MCC in multi-center real-world evidence from Israel. Avelumab was found to be effective and safe in a diverse group of patients, including some with immune suppression.

The phase II KAMELEON study investigated the efficacy of T-DM1 in selected HER2-positive non-breast tumors. Although KAMELEON was terminated prematurely due to recruitment difficulty, the study demonstrated that patients with HER2-positive urothelial bladder cancer or pancreatic cancer can respond to T-DM1. This study provided insight into the prevalence of HER2 positivity and expression patterns in these tumor types and may inform the use of T-DM1–based regimens in HER2-positive non-breast tumors.

The effectiveness of intraoperative intravesical chemotherapy is an important, but understudied, for preventing tumor residue. This study aimed to explore and verify the effect of intraoperative instillation of chemotherapy during radical cystectomy. A single intraoperative instillation of chemotherapy during radical cystectomy was not related to better disease free survival or overall survival.

This retrospective study examined the impact of the COVID-19 pandemic on perioperative chemotherapy for breast cancer. Patients with breast cancer who received perioperative chemotherapy were divided into 2 groups: 120 and 384 patients who started chemotherapy before and during the pandemic, respectively. Although no significant difference in the incidence of critical events that had potential detrimental effects on the prognosis, such as start of adjuvant chemotherapy ≥91 days after surgery and relative dose intensity of chemotherapy <85% was found, the incidence tended to increase through the outbreak periods, particularly the fifth and sixth periods.

In this multicenter, single-arm study, we investigated the anti-tumor activity and safety of neoadjuvant camrelizumab plus gemcitabine and cisplatin for MIBC patients. The pCR was 43.3% in evaluable patients. Our study met its primary endpoint, and a randomized trial is currently underway.

Individual comorbidities associate differently with surgery and chemotherapy in colorectal cancer.

Intensity-modulated proton and/or carbon-ion radiation therapy provided satisfactory therapeutic effectiveness in our head and neck squamous cell carcinoma patients with tolerable acute and late toxicities.

The degradation of Tryptophan to Kynurenine is catabolized by tryptophan enzymes, including IDO1, IDO2, TDO2, and IL4I1, which up-regulate PD-L1 expression and promote tumor suppressive microenvironment in various cancers. In the present study, we constructed tissue microarrays and performed in situ staining of Trp-catabolizing enzymes and PD-L1 using immunohistochemistry in the diffuse large B-cell lymphoma (DLBCL) or natural killer/T-cell lymphoma (NK/TCL). We provide potential strategies for Trp metabolism enzyme inhibitors in combination with anti-PD-L1 or other immunotherapeutic strategies in clinical DLBCL or NK/TCL treatment.

In this cohort study of 58 young adult cancer survivors and 27 comparably aged, noncancer comparators, epigenetic age was greater among survivors compared to controls. Among survivors, greater epigenetic age was associated with myopenia and frailty. Young adult cancer survivors have greater epigenetic age potentially providing a useful tool to assess risk for physiological impairment, disability, and poor health.

Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics. Histopathological-based models may be used to stratify patients into low- and high-risk classes. TSRs of the inner tumor and invasive tumor front can predict the prognosis of OSCC patients.

The cumulative incidences for the development of any type of cancer based on the index score groups for each index. The differences of cumulative incidence based on the FIB-4 index were the most obvious, but all indexes were significantly associated with cancer development (all p < 0.01).

This study validated the use of The Milan System for Reporting Salivary Gland Cytopathology in a large series of 2156 cases in a tertiary center in Switzerland. ROM was determined from 753 cases with histopathological follow-up and compared with data from MSRSGC and other studies.

The recently released National Cancer Database (NCDB) database proved the most updated trends in the prevalence, management, and diagnosis of malignant mesothelioma. Due to the small numbers of patients at most academic centers, the NCDB provides a robust dataset to draw upon broad data points in treatment discussions with patients.

As a conversion therapy for GCLM, immunotherapy yielded better primary and metastatic tumor regression and survival benefit, with no increase in adverse events than did chemotherapy.

In this real-life study of survival with checkpoint inhibitor therapy for multiple tumour entities, we observed an independent association of pre-treatment comorbidities, CRP and eosinophil count, and occurrence of irAE with improved overall survival. These parameters represent promising markers for predicting treatment response.

Here we tested the prognostic accuracy of the Graded Prognostic Assessment (GPA) score model in patients operated for BM and explored further prognostic factors. We confirm the prognostic value of the GPA score in a cohort of operated patients with brain metastasis. However, extent of resection and steroid use provide additional aid for the prognostic assessment in these patients.

Overall survival duration in patients with HCC treated with Atez/Bev according to treatment response by RECIST. The black, dotted, and thin line indicates the PR, SD, and PD group, respectively.

Sensitivity of on-site cytology for malignancy in liver tumor biopsy was comparable to that of conventional cytology. Non-hepatocellular carcinomas (Non-HCC) detection sensitivity using conventional (99.3%) and on-site cytology (99.3%) were significantly high. On-site cytology may be useful for patients with advanced cancer for quick initiation of treatment, because on-site cytology with clinical information enabled the clinical diagnosis of most non-HCC tumors (126/140, 90.0%).

TP53 is the most commonly mutated tumor suppressor gene across all cancer types. We show that four factors determine the response to chemotherapy in patients with metastatic solid tumors harboring the TP53 mutation.TP53 mutations can predict different outcomes following chemotherapy and immunotherapy.

Routinely measured hematological parameters have added diagnostic value in patients on checkpoint inhibitors who visit the emergency department with suspected immune-related adverse events. The physician's preliminary diagnosis had an AUROC of 0.67, which improved to 0.79 after adding four hematological parameters.

Prognostic tool is unmet for human immunodeficiency virus (HIV)-related DLBCL individuals in the era of combined antiretroviral therapy. In this retrospective multicenter observational study, we innovatively developed and externally validated a simple, feasible, and powerful new prognostic model in the HIV-related DLBCL setting, which integrated host immunity. The novel index was superior to the traditional IPI score in terms of discrimination, risk stratification, and predictive accuracy, to inform individualized treatment decisions.

Among patients with brain relapse after complete resection of lung adenocarcinoma, patients with EGFR mutations might have intracranial relapse only without synchronous extracranial metastases. Further prospective studies are warranted to verify this.

Acupuncture in addition to usual care may increase the complete control of chemotherapy-induced acute vomiting and delayed vomiting but the certainty of evidence was very low. A total of 24 different acupoints had been used, most often ST36, PC6, and CV12.

CircFAM114A2 exerts a tumor suppressor role in hepatocellular carcinoma (HCC) through miR-630/HHIP axis and may be served as a potential diagnostic and therapeutic biomarker for HCC patients.

Administration of anti-GM2 IL-7/CCL19-producing chimeric antigen receptor (CAR)-T cells induced complete regression of xenografted human small-cell lung cancer. Abundant T cell infiltration into the solid cancer tissue and long-term memory responses was induced along with antitumor efficacy.

Schematic representation of lymphocyte antigen 6 complex locus K (LY6K)-mediated regulation of transforming growth factor-β (TGF-β) and epidermal growth factor (EGF) signaling pathways.

Flow chart of the present study. The TCGA-HNSCC cohort was used as the exploration set, and samples from GSE13601, GSE25009, GSE30784, GSE41613, and GSE65858 were used as the validation sets.

MiR-1290 was enriched in hypoxic LUAD cancer cell-derived exosomes and could be transferred to macrophages. Furtherly, miR-1290 induced macrophage M2 polarization by activating the SOCS3/STAT3 pathway, which promoted LUAD progression.

In this nested case-control study, we found that being overweight or obese and metabolically unhealthy raises risk of postmenopausal breast cancer while overweight or obese women with normal insulin levels are not at higher risk. These findings are consistent with findings from previous cohort studies.

Cancer survivors often incur cancer-related cognitive impairment (CRCI). Computerized cognitive training and cognitive stimulating-based games have been used to improve CRCI. These methods have been shown to be well received and engaging; however more research is needed to engage patients in these programs for optimal results.

Lnc RNA expression profiles between gastric cancer and control plasma were compared using the Human LncRNA Microarray with RP11-244 K5.6 as a potential noninvasive biomarker.

How does the presentation and outcome of patients with rhabdomyosarcoma treated on clinical trials differ by race and ethnicity?

Clear cell renal cell carcinoma is an obesity-related subtype of kidney cancer which is unevenly affecting racial and ethnic minority groups. Hispanics have different molecular characteristics from non-Hispanic Whites, potentially due to different prevalence of risk factors. Molecular variations likely impact use of molecular biomarkers to assess disease progression in diverse patient populations.

This multinational, qualitative secondary analysis demonstrates how communication transformed the effects of the COVID-19 pandemic on patients and families. The findings of this study emphasize the importance of developing communication centered interventions as a means of mitigating impacts on patient care.

We performed a retrospective cohort analysis of 274 pediatric ALL/ALLy patients within Montefiore Health System from 2004 to 2021 to determine differences in all-cause mortality within the Pediatric Hematologic Malignancies Cohort using Cox Proportional Hazard regression modeling, adjusted for age at diagnosis, race/ethnicity, administration of intensive chemotherapy, preferred language, maximum glucose, and hypertension. Hispanic patients were 78% less likely to die (HR 0.22; 95% CI 0.07, 0.73) when compared with Non-Hispanic Black individuals, while Spanish speakers were 2.91 times more likely to die compared with those who spoke English languages (HR 2.91; 95% CI 1.08, 7.82). Hispanic children with ALL/ALLy have improved survival outcomes compared with Non-Hispanic Blacks, but Spanish language preference was strongly associated with poorer survival, a novel finding that should be validated in future studies.

Undiagnosed Type 2 diabetes (T2D) has been associated with advanced stage cancer at diagnosis, higher mortality, and lower long-term all-cause survival. This was a pilot RCT study to examine the feasibility of a nurse-led T2D intervention for adults with newly diagnosed cancer (=3 months), and T2D, undiagnosed or untreated with medication, conducted at an outpatient oncology clinic affiliated with a large academic institution. This study was not feasible due to the cost, time, and personnel needed to screen participants with a point-of-care HbA1c test.

In this study, SMC1A has the potential to serve as a bidirectional target switch, regulating both the immune microenvironment and cancer stem cells simultaneously. Additionally, SMC1A may function as a biomarker for predicting the effectiveness of immune checkpoint inhibitor (ICI) therapy.

Integrating single cell data and bulk data to identify prognostic cells and their molecular characteristics related to survival of breast cancer.

Flowchart of study design.