Hyponatremia resulting from para-neoplastic Syndrome of Inappropriate Antidiuretic Hormone is common in many types of cancer and correlates with poor outcomes. In this subanalysis of the Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT) clinical trials, once-daily oral tolvaptan safely restored serum sodium levels in cancer patients with SIADH, thereby reducing the need for fluid restriction and electrolyte infusions.

SMAD4 loss in epithelial cells possibly contributes to changes in stromal features. SMAD4 may be a useful predictive marker for malignant transformation of oral leukoplakia.

We identified serum N-glycans to be potential biomarkers as a germ-cell tumor (GCT). Our newly developed diagnostic N-glycan score was significantly associated with GCT detection, 10 of 12 (83%) patients with negative conventional tumor markers were detected by N-glycan score. Our results suggest that the serum N-glycan profiles acquired by glycoblotting and mass spectrometry have potential utility as a biomarker for the presence of GCT.

Ubiquinol–cytochrome c reductase hinge protein (UQCRH), a mitochondrial hinge protein, is frequently overexpressed in HCC tissues (46.8%) and an independent poor prognostic factor for HCC patients. In patients with elevated AFP levels considered the “high–risk” group, lack of UQCRH overexpression may be a useful indicator for clinical treatment.

Patients with a personal history of multiple cancers and new brain metastases can be very challenging from a management standpoint because the histology of their brain lesions may not be clear without biopsy. Our study demonstrates that MRI perfusion can help differentiate between hypervascular and hypovascular brain metastases and potentially facilitate more optimal treatment planning.

Human podoplanin, a platelet aggregation-inducing transmembrane glycoprotein, is expressed in different types of tumors. In this study, we developed chLpMab-2, a human–mouse chimeric anti-hPDPN cancer-specific antibody. chLpMab-2 could be useful as a novel antibody-based therapy against hPDPN-expressing tumors with no unexpected side effects.

In our studies, we show that miR-126 is downregulated with CLL disease progression. miR-126 expression is negatively correlated with levels of p85β, a regulatory subunit of PI3K complex, in CLL patients. In leukemia cell-line models, miR-126 overexpression can decrease p85β level and prosurvival MAPK signaling.

In my manuscript, we have demonstrated acidified bile acids enhanced tumor progression and telomerase activity in gastric cancer, and that these effects are dependent on c-Myc activity. These findings suggest that acidified bile acids play an important role in the malignant progression of reflux gastric cancer.

In this study, we succeeded in creating 15-1-32, a fully human antibody that recognizes membrane-bound carcinoembryonic antigen (CEA). 15-1-32 shows a higher binding affinity for membrane-bound CEA than other CEA antibodies, and is only slightly influenced by soluble-form CEA. 15-1-32-drug conjugate (15-1-32-vcMMAE) showed enhanced antitumor activity against gastric cancer cell lines in the presence of high concentrations of soluble CEA.

Treatment with dasatinib is often associated with peripheral edema, pleural effusion, and pulmonary hypertension. We investigated the effect of dasatinib on endothelial cells and show that at therapeutic concentrations, dasatinib inhibits endothelial cell spreading and the phosphorylation of p130CAS, paxillin and vinculin, cytoskeletal molecules localized to focal adhesions, forming a basis for increased vascular permeability seen in patients.

We treated three different cell lines to confirm that GOLPH3 promoted EMT process and metastasis in epithelial ovarian cancer. Furthermore, we successfully proved the existence of GOLPH3–Wnt/β-catenin–EMT axis in epithelial ovarian cancer.

This Janus-like activity of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1-L) remains enigmatic. Here, we reveals that CEACAM1-L transduces negative signals via SHP-1 (as in mastocytosis) and does positive signals via Src family kinases (as in medullary thyroid carcinoma).

This article describes original research showing that among prostate cancer patients treated by radical prostatectomy, smoking status is associated with overall mortality. The relationship between smoking status and prostate cancer treatment outcome after radical prostatectomy is less clear.

The study is based on measured mid-life cardiorespiratory fitness (CRF), which reflects aerobic activity performed over time and may be well suited to capture health consequences of an active versus sedentary lifestyle. The analyses indicate a benefit of having high CRF, for several cancers. Compared to men with low CRF, men with higher CRF have reduced risk of cancer at proximal colon, lung, pancreas, and bladder.

Trend analysis revealed a recent increase of the incidence of late stage gallbladder cancer. Surgery or radiation improves survival with highest survival associated with receiving both modalities of treatment.