Epac2, but not Epac1, was predominantly expressed in the liver. Epac signaling participates in glucagon-induced glucogenesis by regulating glucokinase translocation and the expression of gluconeogenic enzymes in primary rat hepatocytes.

We investigated the association between short-term recovery of insulin secretion during hospitalization and clinical background or future glycemic control in patients with type 2 diabetes. According to our results, short-term recovery of insulin secretion in response to a meal during hospitalization might predict future glycemic control.

This retrospective population-based cohort study aimed to assess the efficacy and safety of low-dose aspirin for primary prevention in patients with diabetes and pre-end-stage renal disease. This study showed that low-dose aspirin did not reduce cardiovascular mortality, nor increase the risk of major bleeding and renal disease progression. These findings do not support the use of aspirin for primary prevention in this high-risk population.

The study developed 3 and 6 month hypoglycemia risk prediction models for patients with type 2 diabetes, and visualized the use of the models by nomograms. Age, central obesity, intensive insulin therapy, frequency of hypoglycemia in the past year and hypoglycemia prevention education entered both model_3month and model_6month. The study found that risk factors of hypoglycemia were different in the different stages, suggesting that a dynamic assessment of the risk of hypoglycemia was needed.

The current findings support the hypothesis that SUA levels might be involved in the early, rather than advanced, stages of glucose metabolism disorder. Patients with pre-diabetes and newly diagnosed diabetes might be at a higher risk of hyperuricemia. The findings are of great significance for the management of diabetes.

Estimated small dense low-density lipoprotein cholesterol was positively associated with the risk of developing nonalcoholic fatty liver disease, independent of low-density lipoprotein cholesterol. The predictive value of estimated small dense low-density lipoprotein-cholesterol was stronger than that of low-density lipoprotein cholesterol and estimated large buoyant low-density lipoprotein cholesterol.